A5020618573- Inflammatory Bowel Disease
- Microscopic Colitis
- Pharmacological Effects of Natural Compounds
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Systemic Lupus Erythematosus Research
- Biomarkers in Disease Mechanisms
- Anorectal Disease Treatments and Outcomes
- Hidradenitis Suppurativa and Treatments
- Hepatitis C virus research
- Celiac Disease Research and Management
- Medicine and Dermatology Studies History
- Medical and Biological Ozone Research
- Immunodeficiency and Autoimmune Disorders
- Medical and Biological Sciences
- Gastric Cancer Management and Outcomes
- Delphi Technique in Research
- Hepatitis B Virus Studies
- Colorectal Cancer Treatments and Studies
- Appendicitis Diagnosis and Management
- Pharmaceutical Economics and Policy
- Liver Diseases and Immunity
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders
- Cardiac, Anesthesia and Surgical Outcomes
State Scientific Center of Coloproctology
2020-2024
Scientific Research Institute of Healthcare Organization and Medical Management
2018-2022
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The National Registry of Patients with Inflammatory Bowel Disease (IBD) in the Russian Federation was established to study epidemiological and clinical characteristics patients evaluate actual practice medical surgical treatment. AIM : analyze data IBD including demographic characteristics, status patients, frequency use various classes drugs response treatment, survival rates advanced therapy reasons for their cancellation. METHODS from May 2017 August 2021, depersonalized 3827 adult...
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Сombination of two or more biological immunosuppressive drugs in order to achieve a synergistic effect patients with refractory inflammatory bowel disease (IBD) has been the spotlight for many years. Combination therapy may include various medications, most often and immunosuppressants. Despite fact that IBD traditionally focused on block tumor necrosis factor-alpha, development new act different targets, such as vedolizumab, ustekinumab, tofacitinib ozanimod, made it possible use combined...
The purpose of this study was to the effectiveness ustekinumab (UST) depending on dosage regimen (90 mg subcutaneously once every 8 or 12 weeks) in patients with Crohn's disease (CD) who have unfavorable prognosis factors. Material and methods. To assess drug, we included 38 CD had factors, were randomized into two groups received drug a 90 subcutaneous weeks (1-st group, n = 20) (2-nd 18). gender age patient analyzed, including at time diagnosis, severity prevalence CD; presence intestinal...
to estimate the quality and availability of medical care for patients with ulcerative colitis (UC) Crohn's disease (CD), assess impact economic burden these diseases on healthcare budget Russia systematize main problems in organization drug supply inflammatory bowel (IBD). Regional IBD databases (2016-2018), official statistical databases, costs treatment results expert interviews specialists were used study. The analyzed showed 104,668 UC 2018 (prevalence rate 71 per 100,000 people) 66,647...
AIM: to analyze basic medical care characteristics for hemorrhoidal disease (HD) in federal subjects of Russia 2018. MATERIALS AND METHODS: the study is based on summary data annual statistical observation form «Report chief coloproctologist subject Russian Federation» 2018, which includes level outpatient treatment HD per 100,000 population, number coloproctologists, hospitalized patients HD, rate emergency indications and coloproctological beds. RESULTS: 2018 there were 304.9 visits...
The aim of present study was to evaluate a role peripheral blood mononuclear cell (PBMC) infection with hepatitis C virus (HCV) in chronic (CHC) progression under experimental conditions. To this purpose, structural core-protein and nonstructural proteins viral replication complex, as well genomic replicative RNA chains were determined PBMCs CHC patients. Blood samples analyzed from 83 patients at different stages the disease. Viral identified PBMC by cytochemical staining flow cytometry...
AIM: to establish the consensus on controversial issues of surgery for Сrohn’s disease by Delphi method. METHODS: a cross-sectional study was conducted 62 experts voted intramural and anonymous (31.03.23). 5 statements from current edition clinical guidelines were selected correction working group further voting [2]. Based practical experience literature data, 3 new created also. Statements that do not reach required level agreement (80% or more) will be subjected Round 2 RESULTS: all took...
The article describes the main achievements in study of Crohn's disease, first described as a disease terminal ileum, affecting mainly young people, characterized by subacute or chronic necrotizing and scarring inflammation. In subsequent years, inflammatory was also detected other parts gastrointestinal tract. This affects entire intestine can involve every part tract, from mouth to anus. history for 90 years has made it possible delve deeply into pathogenesis inflammation, but not yet come...
The article describes the main achievements in study of ulcerative colitis (UC) - a disease known since ancient times. «Bloody» non-epidemic diarrhea was described by Hippocrates. first detailed description made K. Rokitansky 1842. In 1875, S. Wilks and W. Mason studied pathomorphology colon UC. term «non-specific colitis» proposed Russian surgeon A. Kazachenko 1913 at 13th Congress surgeons. historical excursion presents stages surgical treatment
Aim . To work out the unified model for description of coloproctological service at level federal district. Material and methods The study is summary analysis data from annual statistical observation “The Report Chief Coloproctologist Russian Federal District” in 2016–2018. included following stages: estimation staff situation; assessment main parameters out- inpatient care 2018 Far Eastern District (FEFD) its subjects. Results Staff number doctors subjects FEFD did not change significantly...
Background: Alpha-1-antitrypsin (AAT) is a protein that the main inhibitor of neutrophil elastase and released during inflammatory processes to reduce activity proteolytic enzymes in areas inflammation. An indicator diagnosis diseases small large intestine. AAT plays an important role pathogenesis regulation process bowel diseases, can be used as diagnostic prognostic markers patients with intestinal lesions. The aim study was determine level α-1-antitrypsin blood serum feces UC without...
Introduction. Tofacitinib is the first member of a new class targeted synthetic anti-inflammatory drugs for treatment ulcerative colitis (UC). The article presents three-year Russian experience tofacitinib use moderate and severe UC. Aim study . To evaluate efficacy safety therapy in real clinical practice to UC patients during three years follow-up. Methods. included 56 with who had (60.7%) (35.8%) states disease, total lesion was diagnosed 67.8%, extraintestinal manifestations 57.1%...
The level of soluble forms (s–forms) membranous antigenes can reflect the cellular immunity state and play a role diagnostic predictive markers in various diseases. Quantitative detection serum levels sFas (CD95), sCD38 sHLA–DR was carried out 135 patients with acute chronic hepatitis C. concentrations antigens were defined sandwich ELISA use monoclonal polyclonal antibodies to sFas, antigens. received results have been compared virological, clinical morphological data. increase investigated...
In real clinical practice, unlike in the registered controlled trials, analytical group includes all patients who are being treated with a drug. The aim is to evaluate efficacy and safety of vedolizumab (VDMB) therapy practice ulcerative colitis (UC) for five years. Material methods. study included 136 UC (men 53.7%, women 46.3%), average age – 33.8 ± 4.4 years, duration disease 3.1 0.4 years (52.9% moderate severity, 72.1% total lesion 64.4% chronic recurrent course, 17.6% cases...
Background. COVID-19 is an infectious respiratory syndrome with a wide range of manifestations and outcomes. Patients inflammatory bowel disease (IBD) generally have higher risk infection, especially if they receive immunosuppressive therapy.
 Aim to describe the in patients IBD determine factors for severe COVID-19.
 Methods. The analysis included 68 established diagnosis Crohns (CD) or ulcerative colitis confirmed new coronavirus infection. infection was when SARS-CoV-2 detected...
Introduction . According to clinical guidelines, the treatment of patients with ulcerative colitis (UC) is carried out as combination therapy mesalazine in rectal forms. The aim was compare effectiveness moderate severity UC receiving MMH monotherapy and for use. Materials methods Comparative analysis results MMX (1st group, 44 patients) use (microclysters, suppositories) (2nd 40 performed. Results discussion After 2 weeks MMX, 95.0% 1st group responded continued it (without microclysters...