A5023370661- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Gastroesophageal reflux and treatments
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- IgG4-Related and Inflammatory Diseases
- Digestive system and related health
- Medicine and Dermatology Studies History
- Intestinal and Peritoneal Adhesions
- Climate Change and Health Impacts
- Antioxidant Activity and Oxidative Stress
- Smoking Behavior and Cessation
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
Kazan Federal University
2015-2024
Kazan State Medical University
2012-2021
Human gut microbiome plays an important role both in health and disease. Use of antibiotics can alter microbiota composition, which leads to various deleterious events. Here we report a whole genome sequencing metagenomic/genomic study the intestinal changes caused by Helicobacter pylori (HP) eradication therapy. The analyzed dataset included 80 metagenomes from 40 patients before after HP obtained SOLiD 5500W technology, 10 ones 4 Illumina HiSeq 2500 19 genomes Enterococcus spp. recovered...
Background. Recently, there has been an increase in the prevalence of gastroesophageal reflux disease (GERD) Northern Europe, North America and East Asia. However data on GERD Russian population are very limited. Aim. To determine among Russia, clinical spectrum symptoms, main drugs used for treatment, rate their administration. Materials methods. The study was conducted from November 2015 to January 2017 8 cities Russia. A survey patients over age 18 years old visiting outpatient medical...
H. pylori eradication therapy leads to significant changes in the gut microbiome, including influence on microbiome’s functional potential. Probiotics are one of most studied potential methods for reducing microbiota-related consequences antibiotics. However, beneficial effects probiotics still under discussion. In addition, there some concerns about safety probiotics, emphasizing need research other therapeutic interventions. The aim our study was evaluate butyric acid+inulin supplements...
One of the reasons for decrease
Crohn's disease (CD) is a chronic inflammatory bowel that can be diagnosed at any age. There are two major patient groups based on diagnosis of this disease, before or after the age 20 (juvenile/adolescent adult), with progression in adults usually milder than juvenile CD patients. Immune mechanisms have been suggested to play an important role pathogenesis, cytokines governing development immune response. Upregulation serum and adult patients has documented; still little known about...
Gastroduodenitis caused by H. pylori, often acquired in early childhood, is found about 50% of the adult population. Although pylori infections can remain asymptomatic, its virulence factors usually trigger epithelial vacuolization and degeneration, loss microvilli, disintegration cytoplasm, leukocyte accumulation. It believed that infiltration driven cytokines produced locally infected tissue. However, so far little known changes serum juvenile patients with pylori. Serum cytokine profiles...
Background. As part of an observational multicenter prospective study European Registry on the management Helicobacter pylori infection, conducted initiative H. and Microbiota Study Group, compliance clinical practice in patients with infection Kazan guidelines was assessed. Materials methods. The data 437 included into register by sites 20132019 were analyzed. methods used for initial diagnosis eradication control evaluated. frequency various therapy regimens prescription analyzed 379...
The effects of acrolein and crotonaldehyde on the health Russian smokers upon switching to heated tobacco product use were analyzed in a five-day randomized clinical trial. findings suggest that products significantly reduce exposure these toxicants, with adverse becoming less pronounced just one day comparable complete cessation smoking. dynamics nicotine intake metabolism who switched remained stable throughout study was similar group regular cigarette smokers. Therefore, our study, which...
Aim. Investigation of the prevalence various H. pylori genotypes among children and adult population Kazan with chronic gastroduodenal pathology.
 Methods. The study included 107 patients (49 58 adults) gastritis/gastroduodenitis gastric duodenal ulcer who had infection confirmed by molecular genetic method. All underwent biospy from antral mucosa during endoscopy for verification polymerase chain reaction genotyping сagA babA genes iceA vacA allels. 
 Results. CagA gene was found...
Increased blood cholesterol level is one of the most studied risk factors for cardiovascular diseases. While benefits statins in secondary prevention are shown, their role primary not clear. To assess potential statin use diseases, we searched databases published data English language analyses clinical trials The on outcomes were extracted to calculate ratio beneficial effect no (benefit/no - BNER). One Cochrane systematic review and 5 meta-analyses found, including 27 trials. authors four...
Aim : to assess the composition of microbiota mucous membrane body and antrum stomach. Materials methods . Sixty patients with dyspeptic symptoms were included into study. Two biopsy samples gastric mucosa (from stomach antrum) obtained from each patient. The presence H. pylori infection was confirmed by PCR; RNA isolated then libraries prepared for metatranscriptomic analysis 16S rRNA gene. Sequencing performed on MiSeq (Illumina, USA) using Reagent Kit v3 (600-cycle) USA). Results...
Abstract The human gut microbiome plays an important role both in health and disease. use of antibiotics can alter microbiota composition, which cause complications various kinds. Here we report a whole genome sequencing metagenomic study the intestinal changes caused by Helicobacter pylori eradication therapy. We have found decrease taxonomic alpha-diversity due to observed were more extensive for patients with duodenal ulcer female ones. As well across under therapy detected shifts...
Background. In recent years, much attention has been paid to the importance and role of gut microbiota in human health maintaining its composition violations various diseases. Aim. The aim study was analyze up-to-date literature on intestinal microbiota, composition, functions health, as well factors affecting microbiota. Material methods. An analytical review published studies conducted. Results discussion. development new metagenomic methods for studying led a fundamental breakthrough...
Patients with ulcerative colitis exacerbation associated COVID-19 infection represent a particular group who require additional attention and follow-up due to an increased risk of thrombosis. The article presents clinical case patient born in 1971 association antiphospholipid syndrome. Additionally the had latent inherited thrombophilia, which activation was probably caused by colitis. Nevertheless, there may have been triggering activity that suffered before usually fever morning during...
Abstract. Introduction. IgG4-associated pancreatitis is a rare chronic autoimmune disease characterized by pancreas infiltration with IgG4 cells and an increased level in blood serum. Aim. Present clinical case of pancreatitis. Materials Methods. A presented, describing 22-year- old male patient. Results Discussion. During the examination, following conditions were excluded: Autoimmune liver diseases (ANA, ASMA IgG, LKM-1 IgG – negative, according to elastography, fibrosis 0) primary...
Helicobacter pylori (H. pylori) eradication is obligatory in case of such diseases as gastric and duodenal ulcer, atrophic gastritis, MALT lymphoma, patients after gastrectomy due to the cancer, well close relatives canсer patients. Antibacterial therapy which aimed at H. has an impact on intestinal microbiotа leading its qualitative quantitative disturbances. The review focuses influence content microbiota, their role development microbiota resistance antibiotics. Both itself can lead...
Diarrhea is one of the most frequent adverse events H. pylori eradication therapy due to a violation intestinal microflora The aim study was assess content in pylori-positive and pylori-negative patients, as well effect on its qualitative quantitative composition 78 stool samples were used for analysis: 34 from patients before therapy, - same after completion 10 (control group) A total deoxyribonucleic acid (DNA) isolated by phenol extraction method, nucleotide sequence DNA established...