A5079395419- Diabetes and associated disorders
- Optical Coherence Tomography Applications
- Tendon Structure and Treatment
- Diabetes Management and Research
- RNA Interference and Gene Delivery
- Diagnosis and Treatment of Venous Diseases
- Photoacoustic and Ultrasonic Imaging
- Pancreatic function and diabetes
- Discourse Analysis and Cultural Communication
- AI in cancer detection
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Educational Methods and Teacher Development
- Sociopolitical Dynamics in Russia
- IgG4-Related and Inflammatory Diseases
- European Cultural and National Identity
- RNA regulation and disease
- Diverse Academic Research Studies
- Vascular Malformations and Hemangiomas
- Pharmacological Effects and Toxicity Studies
- Foreign Language Teaching Methods
- Educational Innovations and Challenges
- Diet, Metabolism, and Disease
- Carbohydrate Chemistry and Synthesis
- RNA Research and Splicing
Sechenov University
2019-2025
Penza State Technological University
2024
Penza State University
2016-2024
State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan
2022-2023
Moscow State University of Fine Chemical Technologies
2012-2015
Lomonosov Moscow State University
2012-2015
The aim was to conduct a comparative morphological analysis of the effect implantation and modified adenovirus Ad 5/3 on efficiency local gene delivery cells peri-implantation niche in vivo. Material methods . experiments were carried out laboratory rats, which implanted with collagen membranes for period 2 weeks. Three seven days after introduction adenoviruses (wt, 5/3), tissues fixed histological examination transduced by situ PCR. Results. results showed that presence implant improved...
Proton beam therapy (PBT) is a rapidly advancing modality of hadron therapy. The primary advantage proton lies in unique depth-dose distribution characterized by the Bragg peak, which enables highly targeted irradiation area limited to tumor, while minimizing impact on healthy tissues. However, broader clinical adoption ion both economic and radiobiological constraints. One possible ways increase relative biological effectiveness (RBE) involves use radiosensitizers. Background/Objectives: In...
RNA interference (RNAi)-based therapeutics hold the potential for dominant genetic disorders, enabling sequence-specific inhibition of pathogenic gene products. We aimed to direct RNAi selective suppression heterozygous
The aim of the study was to test method optical coherence tomography (OCT) for its ability obtain images blood and lymphatic vessels vulva.Materials Methods.The performed using a multimodal device developed in Institute Applied Physics Russian Academy Sciences (Nizhny Novgorod).In this setup, 3D 3.4×3.4×1.25 mm are created within 26 s.OCT angiography OCT lymphangiography based on speckle structure analysis.Visualization does not require any additional contrast agents.A histological vulvar...
The aim of the study is to analyze functions and forms Boborykin’s references Shakespeare’s dramatic heritage determine extent Shakespearean theatre’s influence on formation writer’s creative system. material consists feuilletons articles by P. D. Boborykin for journals “Library Reading” (1861, 1862), “Case” (1871), “Word” (1878), publications in newspapers “New Time” (1876), “Theatrical World” (1887), as well book Art” (1872) memoirs “For Half a Century” (1929, 1965). It shown that his...
Lymphovascular invasion (LVI) in lung cancer is a significant prognostic factor that influences treatment and outcomes, yet its reliable detection challenging due to interobserver variability. This study aims develop deep learning model for LVI using whole slide images (WSIs) evaluate effectiveness within pathologist's information system. Experienced pathologists annotated blood vessels invading tumor cells 162 WSIs of non-mucinous adenocarcinoma sourced from two external one internal...
This article explores the reception of poetry from antiquity, Middle Ages, and Renaissance within journal “Russian Messenger,” examining editorial policies that shaped its content. The study is based on a complete set issues Messenger” published between 1856 1906. Analyzing poetic translations, adaptations, interpretations provides insight into ideological framework one leading journals late 19th century. relevance this underscored by recent surge in interest both humanities broader public...
The degree of influence the worldview a certain ethnic group on implementation in its lyrics substantive features themes and motifs common to world literature is explored. For this, analysis artistic embodiment theme Motherland related poems by poets peoples Russia writing national languages was undertaken. During research process, no exceptional, specific expression were found analyzed works. author comes conclusion that national-cultural specificity does not prevail eternal themes. In this...
The study of the sociomedical problems diabetes mellitus led to discovery latent autoimmune in adults (LADA), a special form disease. slow onset disease, clinical signs type 2 concurrent with autoantibody pancreatic β-cell destruction mechanism that is characteristic 1 diabetes. Genetic factors play an important role genesis Insulitis intact or hypertrophic islets gland originally develops morphologically. Subsequently, phenomena islet atrophy and sclerosis are progressive. disease typical...
The purpose of the study was in vivo assessment vulvar blood and lymphatic vessels characteristics norm lichen sclerosus by multimodal optical coherence tomography (OCT). performed using a OCT setup developed at Institute Applied Physics RAS (Russia). angiography lymphangiography are based on analysis speckle structure. Visualization lymph does not require use exogenous contrast agents. A histological biopsy samples from two points carried out for 10 patients without pathology 12 with...
Lichen Sclerosus is a chronic recurrent inflammatory dermatosis of unknown etiology, which affects both the skin and also mucous membrane usually localized at genital area. OCT angiography promising tool for microcirculation mapping in 3D with ~micrometer resolution. During study, we developed implemented robust real time realization routine clinical practice. This allows clinicians to combine structural imaging angiograms during Normal vulvar mucosa dystrophic were analyzed by multimodal...
Dystrophic diseases of the vulva represent a large group dermatoses. The clinical picture these lesions is often nonspecific, and non-invasive diagnosis ineffective. in vivo dystrophic difficult due to lack informative imaging methods for examining vulvar mucosa. new method multimodal optical coherence tomography (OCT) approach biological tissues visualization with high spatial resolution, which does not require contrasting agents. Here we report application OCT study mucosa structure its...
IgG4-related disease is a chronic inflammatory fibrosing of unknown etiology, characterized by the presence volumetric lesions that can clinically simulate malignant tumors, pronounced IgG4-positive lymphoplasmacytic infiltrate, and an increase in level IgG4 blood serum. A special form ophthalmopathy, which requires differential diagnosis with pseudotumor, lymphoma granulomatous polyangiitis. 7 clinical cases ophthalmopathy are presented. It has been shown follicle-like structures structure...
Аннотация.В статье анализируются жанрообразующие признаки произведений А
IgG4-related disease is a chronic autoimmune fibro-inflammatory characterized by the presence of lymphoplasmacytic infiltrate, storiform fibrosis, obliterating phlebitis, increased number IgG4+ cells in tissue, and, most cases, an elevated serum IgG4 level. This often affects pancreas, salivary glands and lymph nodes, but can involve almost any tissue. Its etiology still unclear, central role pathogenesis belongs to B-lymphocytes, T2-helpers, interleukins 1-β, 4, 5, 10, 13 tumor growth...
The problems of multiple representations provinciality, as well the formation identity region, are considered in article.Based on analysis an array sources published and introduced into scientific circulation for first time (office materials, epistolary heritage documents, fiction literature), results research practice, factors, content specifics development self-awareness Penza community determined abolition serfdom liberal reforms 1860th context.The unique experience reception exploration...
Латентный аутоиммунный сахарный диабет взрослых А.А. Тимакова, Б
The article analyses the artistic evolution of contemporary writer R. Senchin — from one his most successful novels Yoltyshevs [Yoltyshevy] (2009) to later works such as Runway [Polosa] (2012), a novella, and Flood Zone [Zona zatopleniya] (2015) Rain in Paris [Dozhd v Parizhe] (2018). It is suggested that each question are written response 20th-c. classic: brings back memories Shukshin’s short stories, invokes Rasputin’s Farewell Matyora [Proshchanie s Matyoroy], Vampilov’s Duck Hunting...
В данной статье рассматриваются вопросы профессионального самоопределения личности старшеклассника во внеучебной деятельности; проблема определения содержания понятия «внеучебная деятельность», ее образовательные, развивающие, профориентационные возможности; актуальность проблемы в современном обществе, имеющиеся подходы к пониманию сущности феномена личности.