A5022228111- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Bone Tissue Engineering Materials
- Electrochemical sensors and biosensors
- Advanced Photocatalysis Techniques
- Nanomaterials for catalytic reactions
- Planarian Biology and Electrostimulation
- Radiation Therapy and Dosimetry
- Nanoparticle-Based Drug Delivery
- Laser-Ablation Synthesis of Nanoparticles
- Boron Compounds in Chemistry
- Marine Ecology and Invasive Species
- Dendrimers and Hyperbranched Polymers
- Catalytic Processes in Materials Science
- Advanced Radiotherapy Techniques
- Hydrogels: synthesis, properties, applications
- Transition Metal Oxide Nanomaterials
- Luminescence Properties of Advanced Materials
- Medical and Biological Ozone Research
- Plasma Applications and Diagnostics
- Cardiomyopathy and Myosin Studies
Institute of Theoretical and Experimental Biophysics
2016-2025
P.N. Lebedev Physical Institute of the Russian Academy of Sciences
2024-2025
NS Kurnakova Institute of General and Inorganic Chemistry
2021-2023
Russian Academy of Sciences
2011-2021
Moscow Region State University
2016
Different radioprotective action mechanisms of CeO<sub>2</sub> nanoparticles <italic>in vitro</italic> and vivo</italic> are demonstrated discussed.
Their unique physicochemical properties and multi-enzymatic activity make CeO2 nanoparticles (CeO2 NPs) the most promising active component of next generation theranostic drugs. When doped with gadolinium ions, NPs constitute a new type contrast agent for magnetic resonance imaging, possessing improved biocatalytic high level biocompatibility. The present study is focused on an in-depth analysis enzyme-like gadolinium-doped (CeO2:Gd their antioxidant against superoxide anion radicals,...
Cerium oxide nanoparticles (nanoceria) are regarded as one of the most promising inorganic antioxidants for biomedical applications. Considering nanoceria a potential therapeutic agent, we aimed to develop robust system its intracellular delivery using layer-by-layer polyelectrolyte microcapsules. We have shown that citrate-stabilized cerium can be effectively incorporated into structure microcapsules made from biodegradable and nonbiodegradable polymers. The morphology synthesized were...
The design of novel, effective drug delivery systems is one the most promising ways to improve treatment socially important diseases. This article reports on an innovative approach production composite microcontainers (microcapsules) bearing advanced protective functions. Cerium oxide (CeO2) nanoparticles were incorporated into layer-by-layer polyelectrolyte microcapsules as a shell for encapsulated enzyme (luciferase Photinus pyralis), preventing its oxidation by hydrogen peroxide, abundant...
Luminescent organic dots (O-dots) were synthesized via a one-pot, solvent-free thermolysis of citric acid in urea melt. The influence the ratio precursors and duration process on properties O-dots was established mechanism their formation hypothesized. multicolour luminescence tunability toxicity extensively studied. possible applications for alive/fixed cell staining labelling layer-by-layer polyelectrolyte microcapsules evaluated.
Ceria nanoparticles are capable of performing the function some enzymes (such as oxidoreductases, phosphatase) and can be classified nanozymes.In this review, actual data on enzymatic activity ceria were critically analyzed specific conditions under which cerium dioxide act defined.The presented analysis may useful in planning, design synthesis having desired functions required for various processes, including development nanodrugs, exhibit therapeutic effect depending their composition pH...
Dextran-coated gadolinium-modified ceria nanoparticles possess excellent colloidal stability, high r 1 -relaxivity, demonstrate efficient cell internalisation and selective cytotoxicity to cancer cells.
CeO 2 nanoparticles were shown to possess two novel types of enzyme-like activity, namely lipoperoxidase and phospholipoperoxidase activity.
Tungsten oxide sol, containing highly crystalline nanoparticles of orthorhombic WO 3 and having good sedimentation stability, was synthesized using a facile, ultrasonic-assisted technique. An additional steric stabilizer, dextran, proposed to enhance the stability in biological media reduce their vivo toxicity. The cytotoxicity dextran-stabilized nonstabilized sols studied vitro dental pulp stem (DPS) cell lines breast cancer (MCF-7) lines. Both tungsten demonstrated low genotoxicity for...
The antimicrobial, anti-inflammatory and tissue-stimulating effects of cold argon atmospheric plasma (CAAP) accelerate its use in various fields medicine. Here, we investigated the CAAP at different radiation doses on mesenchymal stem cells (MSCs) human osteosarcoma (MNNG/HOS) cells. We observed an increase growth rate MSCs sufficiently low irradiation (10–15 min) CAAP, while MNNG/HOS was slowed down to 41% same doses. Using flow cytometry, found that these are associated with cell cycle...
In the ongoing search for practical uses of rare-earth metal nanoparticles, cerium dioxide nanoparticles (nanoceria) have received special attention. The purpose this research was to study biomedical effects nanocrystalline forms oxide obtained by different synthesis schemes and evaluate effect concentrations nanoceria (from 10−2 10−6 M) on cells involved in regeneration skin cell structures such as fibroblasts, mesenchymal stem cells, keratinocytes. Two methods preparation were...
Boron-enhanced proton therapy has recently appeared as a promising approach to increase the efficiency of on tumor cells, and this modality can further be improved by use boron nanoparticles (B NPs) local sensitizers achieve enhanced targeted therapeutic outcomes. However, mechanisms cell elimination under boron-enhanced still require clarification. Here, we explore possible molecular responsible for enhancement outcomes NP-enhanced therapy. Spherical B NPs with mode size 25 nm were prepared...
One of the current approaches to improve effectiveness photodynamic therapy (PDT) is development advanced photosensitizers, including those based on nanoparticles. In this research, we have demonstrated for first time possibility using cerium fluoride nanoparticles, functionalized with riboflavin (Rb-CeF3 NPs), as a nanophotosensitizer PDT. The binding CeF3 NPs results in stabilization these nanoparticles and does not lead formation an amorphous structure. At same time, Rb-CeF3 exhibit...
The use of various nanoformulations for cancer radiotherapy has great potential due to their increased effectiveness and safety. At the stage preclinical evaluation such in vitro, they are tested on monolayers tumor cell cultures, which is an unrealistic representation tumors vivo, leads inaccurate selection suitable drugs. To solve this problem, 3D cellular spheroids becoming additional tool confirming new therapeutic nanoformulations. Here we show possibility using citrate-stabilized...
Proton beam therapy (PBT) is a rapidly advancing modality of hadron therapy. The primary advantage proton lies in unique depth-dose distribution characterized by the Bragg peak, which enables highly targeted irradiation area limited to tumor, while minimizing impact on healthy tissues. However, broader clinical adoption ion both economic and radiobiological constraints. One possible ways increase relative biological effectiveness (RBE) involves use radiosensitizers. Background/Objectives: In...
A technique for the fabrication of bacterial cellulose-based films with CeO2 nanofiller has been developed. The structural and morphological characteristics materials have studied, their thermal mechanical properties in dry swollen states having determined. preparation methodology makes it possible to obtain composites a uniform distribution nanoparticles. catalytic effect ceria, regarding oxidative destruction cellulose, confirmed by TGA DTA methods. An increase content led an elastic...