A5025004266- Radiation Therapy and Dosimetry
- Diamond and Carbon-based Materials Research
- Laser-Ablation Synthesis of Nanoparticles
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Nuclear Physics and Applications
- Advanced Electron Microscopy Techniques and Applications
- Advanced Radiotherapy Techniques
- Effects of Radiation Exposure
- Laser-induced spectroscopy and plasma
- Nuclear reactor physics and engineering
- Carbon Nanotubes in Composites
- Boron Compounds in Chemistry
- Chemical Thermodynamics and Molecular Structure
- Photoacoustic and Ultrasonic Imaging
- Radiation Detection and Scintillator Technologies
- Ion-surface interactions and analysis
P.N. Lebedev Physical Institute of the Russian Academy of Sciences
2021-2025
National Research Nuclear University MEPhI
2024-2025
Proton beam therapy (PBT) is a rapidly advancing modality of hadron therapy. The primary advantage proton lies in unique depth-dose distribution characterized by the Bragg peak, which enables highly targeted irradiation area limited to tumor, while minimizing impact on healthy tissues. However, broader clinical adoption ion both economic and radiobiological constraints. One possible ways increase relative biological effectiveness (RBE) involves use radiosensitizers. Background/Objectives: In...
Abstract The technique of laser ablation in liquids is applied to produce Boron-containing nanoparticles from a Fe 2 B bulk target enriched 10 isotope. Laser the liquid isopropanol results partial disproportionation free and Boron while are also presented. magnetic can be collected using permanent magnet. average size about 15 nm. content generated amounts 76.9%. biocompatible used boron neutron capture therapy.
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing proton with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG at concentrations above 25 mg/L and 4 Gy dose caused complete death EMT6/P cells vitro. Binary using Au-PEG-FA an 80% growth inhibition effect vivo. The use is promising for irradiation on requires further research to increase therapeutic index approach.
Abstract Nuclear nanomedicine forms a new research field based on the synergy of nuclear medicine and nanotechnology implying use nanomaterials as carriers diagnostic or therapeutic radionuclides. Such an approach promises series advantages over classical methods medicine, including increased surface area-to-volume ratio, passive/active delivery, high loading capacity, large cross-section in interactions with biological tissues, unique properties that make possible many functionalities...
The technique of laser ablation in liquids is applied to produce Boron-containing nanoparticles from a Fe$_2$B bulk target enriched 10B isotope. Laser the liquid isopropanol results partial disproportionation free Fe and Boron while are also presented. Nanoparticles magnetic can be collected using permanent magnet. Average size 15 nm. content generated amounts 76,9 %. biocompatible used Neutron Capture Therapy.