A5015279723- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Boron Compounds in Chemistry
- Nanoplatforms for cancer theranostics
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Boron and Carbon Nanomaterials Research
- Graphene and Nanomaterials Applications
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Nuclear Physics and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Anatomy and Medical Technology
- Pharmacological Effects and Toxicity Studies
- MRI in cancer diagnosis
- Laser-Ablation Synthesis of Nanoparticles
- Nanoparticles: synthesis and applications
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Lanthanide and Transition Metal Complexes
- Monoclonal and Polyclonal Antibodies Research
- Radiology practices and education
National Research Nuclear University MEPhI
2023-2025
Institute of Engineering Physics
2024
Ministry of Health of the Russian Federation
2022-2024
NS Kurnakova Institute of General and Inorganic Chemistry
2024
Institute of General and Inorganic Chemistry
2024
Gold nanoparticles have unique physical, chemical and optical properties, due to which they are used develop promising drugs: radiosensitisers, X-ray contrast media, agents for photothermal therapy, drugs targeted delivery. In each case, the choice of nanoparticle parameters is determined not only by field application, but also biodistribution in living organism: blood circulation time accumulation target organs tissues, including tumor. For long circulation, should avoid phagocytosis liver...
Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging a tumor and surrounding normal tissues is crucial both for diagnostics nanoparticle application as radiosensitizers. The Fe3O4 core was introduced into gold form core/shell structure suitable MRI imaging. aim this study assess vivo bimodal CT enhancement ability novel Fe3O4@Au theranostic nanoparticles. Core/shell were synthesized coated with PEG glucose. C57Bl/6 mice...
Metal nanoparticles are capable of enhancing the destructive effect ionizing radiation on biological
 tissue, which allows them to be used as radiosensitizers for improving efficacy cancer radiotherapy. The most promising those with a high atomic number (Z>52), since they can
 serve both dose-enhancing agents contrast-enhanced radiotherapy and contrast media for
 computed tomography. Due metal content in each particle ability selectively accumulate tumor nanoscale can...
In this work, a series of boronated amidines based on the closo-dodecaborate anion and amino acids containing an group in side chain general formula [B12H11NHC(NH(CH2)nCH(NH3)COOH)CH3], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino α-carboxyl groups recognized by binding centers large neutral acid transporter (LAT) system, which serves as target for clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several approaches to...
Purpose. To compare information about the condition of digestive tract obtained by ex vivo radiometry and in imaging methods after administration 177 Lu-DOTA-TATE to rats. Materials methods. The compound was synthesized cyclotron-radiochemical laboratory Department Radionuclide Diagnostics Therapy N. Blokhin National Medical Research Center Oncology. SPECT/CT method used visualize rats Lu-DOTA-TATE. Classical direct post mortem biological samples as a comparison method. In performed...
99mTc is a well-known radionuclide widely used and readily available for medical imaging. Despite this, the isotope rarely utilized tumour imaging due to lack of agents that can selectively deliver it tumours. However, use immunologically compatible recombinant proteins, which combine metal-binding sites tumour-specific ligands, shows promise utilizing in early detection To illustrate protein called E1b, containing metal binding center with ELP repeats, ligands recognizing integrin...
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing proton with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG at concentrations above 25 mg/L and 4 Gy dose caused complete death EMT6/P cells vitro. Binary using Au-PEG-FA an 80% growth inhibition effect vivo. The use is promising for irradiation on requires further research to increase therapeutic index approach.
In this work, a series of boronated amidines based on the closo-dodecaborate anion and amino acids containing an group in side chain general formula [B12H11NHC(NH(CH2)nCH(NH3)COOH)CH3], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino α-carboxyl groups recognized by binding centers large neutral acid transporter (LAT) system, which serves as target for clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several...
BACKGROUND: New treatment methods of castration-resistant prostate cancer with radionuclide therapy are needed. They will optimize personalized strategy for metastatic castrate-resistant using low molecular weight ligands to prostate-specific membrane antigen (PSMA) labeled lutetium-177.
 AIM: To define the long-term effects and effectiveness experimental animals PET imaging refine research strategy.
 METHODS: The study was performed in nu/nu male mice PSMA-expressing 22Rv1...
99mTc is a well-known radionuclide that widely used and readily available for SPECT/CT (Single-Photon Emission Computed Tomography) diagnosis. However, commercial isotope carriers are not specific enough to tumours, rapidly clear from the bloodstream, safe. To overcome these limitations, we suggest immunologically compatible recombinant proteins containing combination of metal binding sites as chelators several different tumour-specific ligands early detection tumours. E1b protein...
Purpose: To analyze the difficulties in teaching students to process and interpret tomography images of laboratory animals, offer recommendations for most effective this skill various specialties. Material methods: typical errors difficulties, we interviewed their supervisors and/or advisors; observed while working with images; analyzed texts students' theses reports. identify habits researchers different education work experience processing interpreting images, conducted interviews...
Background. For in vivo determination of size and metabolic characteristics model tumors laboratory animals, it is recommended to use imaging methods: positron emission tomography (PET), single-photon computed (SPECT), (CT) magnetic resonance (MRI). Due the limited availability hybrid scanners, necessary investigate feasibility obtaining tomograms on separate devices with subsequent geometric comparison images. Aim. To multimodal mice subcutaneous melanoma B16F10. Materials methods. PET,...
Neutron Capture Therapy (NCT) — highly selective method of binary radiotherapy malignancies, which is based on physical phenomenon thermal neutron radiation capture by atoms’ nuclei. Currently only 10B mediated NCT, known as boron therapy (BNCT), used in clinical practice. Boronophenylalanine a modified amino acid most widely carrier. Despite more than 70-years history BCNT application and promising results curing patients with different tumors, this treatment still under research...
Purpose: To show the feasibility of simultaneous trimodal PET/SPECT/CT with 18F-FDG and 177Lu-DOTATATE for characterization syngeneic subcutaneous mouse tumor model.
 Material methods: Female C57Bl/6 mice transplanted melanoma B16F10 were
 used study. Preclinical imaging system MiLabs VECTor 6 (Netherlands) was used. Mice from first control group were intravenously injected 177Lu-DOTATATE
 underwent SPECT/CT. second PET/CT. experimental in one syringe imaging.
 Results:...