A5044487972- Radiopharmaceutical Chemistry and Applications
- Boron Compounds in Chemistry
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Laser-Ablation Synthesis of Nanoparticles
- Boron and Carbon Nanomaterials Research
- Radioactive element chemistry and processing
- Supramolecular Chemistry and Complexes
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Nanoparticles: synthesis and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Inorganic Chemistry and Materials
- Oral and Maxillofacial Pathology
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Graphene and Nanomaterials Applications
- ATP Synthase and ATPases Research
- Prostate Cancer Treatment and Research
- Medical Imaging and Pathology Studies
- Bone and Dental Protein Studies
National Research Nuclear University MEPhI
2021-2025
Institute of Engineering Physics
2022-2024
Ministry of Health of the Russian Federation
2022-2024
National Medical Research Center of Cardiology
2024
Institute of General and Inorganic Chemistry
2024
NS Kurnakova Institute of General and Inorganic Chemistry
2024
Gold nanoparticles have unique physical, chemical and optical properties, due to which they are used develop promising drugs: radiosensitisers, X-ray contrast media, agents for photothermal therapy, drugs targeted delivery. In each case, the choice of nanoparticle parameters is determined not only by field application, but also biodistribution in living organism: blood circulation time accumulation target organs tissues, including tumor. For long circulation, should avoid phagocytosis liver...
Contrast-enhanced radiotherapy (CERT) is a method of radiation therapy based on the interaction dose-enhancing agent with external X-ray radiation. Gold nanoparticles are promising agent. The aim work to determine maximum concentration gold and corresponding dose enhancement factor (DEF) in healthy organs tumor node after intravenous injection tumor-bearing mice, according computed tomography data. Mice subcutaneous syngeneic tumors were used for study: melanoma B16F10 (n=5); adenocarcinoma...
Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging a tumor and surrounding normal tissues is crucial both for diagnostics nanoparticle application as radiosensitizers. The Fe3O4 core was introduced into gold form core/shell structure suitable MRI imaging. aim this study assess vivo bimodal CT enhancement ability novel Fe3O4@Au theranostic nanoparticles. Core/shell were synthesized coated with PEG glucose. C57Bl/6 mice...
Metal nanoparticles are capable of enhancing the destructive effect ionizing radiation on biological
 tissue, which allows them to be used as radiosensitizers for improving efficacy cancer radiotherapy. The most promising those with a high atomic number (Z>52), since they can
 serve both dose-enhancing agents contrast-enhanced radiotherapy and contrast media for
 computed tomography. Due metal content in each particle ability selectively accumulate tumor nanoscale can...
Three artificial proteins that bind the gadolinium ion (Gd3+) with tumour-specific ligands were de novo engineered and tested as candidate drugs for binary radiotherapy (BRT) contrast agents magnetic resonance imaging (MRI). Gd3+-binding modules derived from calmodulin. They joined elastin-like polypeptide (ELP) repeats human elastin to form four-centre domain (4MBS-domain) further was combined F3 peptide (a ligand of nucleolin, a tumour marker) F3-W4 block. The block taken alone (E2-13W4...
Purpose. To compare information about the condition of digestive tract obtained by ex vivo radiometry and in imaging methods after administration 177 Lu-DOTA-TATE to rats. Materials methods. The compound was synthesized cyclotron-radiochemical laboratory Department Radionuclide Diagnostics Therapy N. Blokhin National Medical Research Center Oncology. SPECT/CT method used visualize rats Lu-DOTA-TATE. Classical direct post mortem biological samples as a comparison method. In performed...
99mTc is a well-known radionuclide widely used and readily available for medical imaging. Despite this, the isotope rarely utilized tumour imaging due to lack of agents that can selectively deliver it tumours. However, use immunologically compatible recombinant proteins, which combine metal-binding sites tumour-specific ligands, shows promise utilizing in early detection To illustrate protein called E1b, containing metal binding center with ELP repeats, ligands recognizing integrin...
In this work, a series of boronated amidines based on the closo-dodecaborate anion and amino acids containing an group in side chain general formula [B12H11NHC(NH(CH2)nCH(NH3)COOH)CH3], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino α-carboxyl groups recognized by binding centers large neutral acid transporter (LAT) system, which serves as target for clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several approaches to...
Abstract Binary radiotherapy (BRT) approach for curing malignant tumors is described in the paper. Two main modalities of BRT, i.e. Neutron Capture Therapy and Contrast Enhanced Radiotherapy are being compared. Physics BRT practical implementation discussed. Clinical efficacy treating brain head neck cancer as well pharmacological challenges achievements reviewed.
In this work, a series of boronated amidines based on the closo-dodecaborate anion and amino acids containing an group in side chain general formula [B12H11NHC(NH(CH2)nCH(NH3)COOH)CH3], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino α-carboxyl groups recognized by binding centers large neutral acid transporter (LAT) system, which serves as target for clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several...
BACKGROUND: New treatment methods of castration-resistant prostate cancer with radionuclide therapy are needed. They will optimize personalized strategy for metastatic castrate-resistant using low molecular weight ligands to prostate-specific membrane antigen (PSMA) labeled lutetium-177.
 AIM: To define the long-term effects and effectiveness experimental animals PET imaging refine research strategy.
 METHODS: The study was performed in nu/nu male mice PSMA-expressing 22Rv1...
We report the first synthesis of a polyhedral boron derivative gadolinium (III) phthalocyaninate. Initially, reaction 4-nitrophthalonitrile with 4-formylphenol in presence base was carried out to give 4-(4-formylphenoxy)phthalonitrile. This compound then converted 4-(4-hydroxymethylphenoxy)phthalonitrile using sodium tris-acetoxy borohydride THF. Sequential cyclotetramerisation this semiproduct magnesium acetate, treatment resulting complexes on trifluoroacetic acid and complexation acetate...
99mTc is a well-known radionuclide that widely used and readily available for SPECT/CT (Single-Photon Emission Computed Tomography) diagnosis. However, commercial isotope carriers are not specific enough to tumours, rapidly clear from the bloodstream, safe. To overcome these limitations, we suggest immunologically compatible recombinant proteins containing combination of metal binding sites as chelators several different tumour-specific ligands early detection tumours. E1b protein...
Purpose: To analyze the difficulties in teaching students to process and interpret tomography images of laboratory animals, offer recommendations for most effective this skill various specialties. Material methods: typical errors difficulties, we interviewed their supervisors and/or advisors; observed while working with images; analyzed texts students' theses reports. identify habits researchers different education work experience processing interpreting images, conducted interviews...
Background. For in vivo determination of size and metabolic characteristics model tumors laboratory animals, it is recommended to use imaging methods: positron emission tomography (PET), single-photon computed (SPECT), (CT) magnetic resonance (MRI). Due the limited availability hybrid scanners, necessary investigate feasibility obtaining tomograms on separate devices with subsequent geometric comparison images. Aim. To multimodal mice subcutaneous melanoma B16F10. Materials methods. PET,...