A5027639251- Laser-Ablation Synthesis of Nanoparticles
- Laser Material Processing Techniques
- Radiation Therapy and Dosimetry
- Laser-induced spectroscopy and plasma
- Diamond and Carbon-based Materials Research
- Nonlinear Optical Materials Studies
- Radiopharmaceutical Chemistry and Applications
- Silicon Nanostructures and Photoluminescence
- Nanoplatforms for cancer theranostics
- Laser Design and Applications
- Advanced Radiotherapy Techniques
- Boron Compounds in Chemistry
- Gold and Silver Nanoparticles Synthesis and Applications
- Radiation Detection and Scintillator Technologies
- Nanowire Synthesis and Applications
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Photoacoustic and Ultrasonic Imaging
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Luminescence Properties of Advanced Materials
- Bone health and treatments
- Semiconductor Lasers and Optical Devices
- Medical Imaging and Pathology Studies
- High Entropy Alloys Studies
Moscow Engineering Physics Institute
2015-2024
P.N. Lebedev Physical Institute of the Russian Academy of Sciences
2015-2024
Institute of Engineering Physics
2019-2024
Kurchatov Institute
2024
Institute of Biomedical Chemistry
2022-2023
Lomonosov Moscow State University
2021
Russian Academy of Sciences
1999-2014
Abstract Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along enhanced retention to avoid rapid clearance as faced molecular radiopharmaceuticals, provides unique opportunities treat tumors metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack suitable nanocarriers, which are safe, excretable have favorable pharmacokinetics efficiently deliver retain radionuclides in tumor. Here, we introduce biodegradable...
Abstract Boron-based nano-formulations look very promising for biomedical applications, including photo- and boron neutron capture therapies, but the fabrication of non-toxic water-dispersible nanoparticles (NPs), which contain highest atom concentration, is difficult using currently available chemical plasma synthesis methods. Here, we demonstrate purely aqueous clean NPs by methods femtosecond laser ablation from a solid target in water, thus free any toxic organic solvents, characterize...
Abstract Presenting a safe alternative to conventional compound quantum dots and other functional nanostructures, nanosilicon can offer series of breakthrough hyperthermia‐based therapies under near‐infrared, radiofrequency, ultrasound, etc., excitation, but the size range sensitize these is typically too large (>10 nm) enable efficient imaging functionality based on photoluminescence properties quantum‐confined excitonic states. Here, it shown that Si nanoparticles (NPs) are capable...
Proton therapy is one of the promising radiotherapy modalities for treatment deep-seated and unresectable tumors, its efficiency can further be enhanced by using boron-containing substances. Here, we explore use elemental boron (B) nanoparticles (NPs) as sensitizers proton enhancement. Prepared methods pulsed laser ablation in water, used B NPs had a mean size 50 nm, while subsequent functionalization polyethylene glycol improved their colloidal stability buffers. Laser-synthesized were...
This paper reviews results of experimental and theoretical studies surface micro- nanostructuring metals other materials irradiated directly by short ultrashort laser pulses. Special attention is paid to direct action involving melting the material (with or without ablation), followed ultrarapid solidification, which an effective approach producing nanostructures. Theoretical analysis recrystallisation kinetics after irradiation pulses makes it possible determine volume fraction crystallised...
Boron neutron capture therapy (BNCT) is one of the most appealing radiotherapy modalities, whose localization can be further improved by employment boron-containing nanoformulations, but fabrication biologically friendly, water-dispersible nanoparticles (NPs) with high boron content and favorable physicochemical characteristics still presents a great challenge. Here, we explore use elemental (B) NPs (BNPs) fabricated using methods pulsed laser ablation in liquids as sensitizers BNCT....
We analyzed the formation of aluminum (Al) nanoparticles (NPs) with triangular shape obtained by ablating Al bulk in liquid using pulses different durations (5 ns, 200 ps, and 30 fs) wavelengths (355 nm, 800 1064 nm). report three stages synthesis aging NPs: Formation, transformation, stable stage. The NPs prepared are almost identical at initial effects duration wavelength ablation on revealed. Pulse is determined to be essential for morphological transformation NPs, while pulse strongly...
Boron-enhanced proton therapy has recently appeared as a promising approach to increase the efficiency of on tumor cells, and this modality can further be improved by use boron nanoparticles (B NPs) local sensitizers achieve enhanced targeted therapeutic outcomes. However, mechanisms cell elimination under boron-enhanced still require clarification. Here, we explore possible molecular responsible for enhancement outcomes NP-enhanced therapy. Spherical B NPs with mode size 25 nm were prepared...
HfN nanoparticles exhibiting a tunable plasmonic feature in the near-IR were synthesized by laser ablation liquids. A strong photothermal therapeutic effect yielding 100% cells death under 808 nm irradiation of was reported.
Nuclear nanomedicine is an emerging field, which utilizes nanoformulations of nuclear agents to increase their local concentration at targeted sites for a more effective therapy considerably reduced radiation dosage. This field needs the development methods controlled fabrication carrying nanoparticles with low polydispersity and high colloidal stability in aqueous dispersions. In this paper, we apply femtosecond (fs) laser ablation deionized water fabricate stable dispersion 152Sm-enriched...
We present a framework based on the atomistic continuum model, combining Molecular Dynamics (MD) and Two Temperature Model (TTM) approaches, to characterize growth of metal nanoparticles (NPs) under ultrashort laser ablation from solid target in water ambient. The model is capable addressing kinetics fast non-equilibrium laser-induced phase transition processes at atomic resolution, while it accounts for effect free carriers, playing determinant role during short pulse interaction with...