A5033863410- Nuclear Physics and Applications
- Boron Compounds in Chemistry
- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Nuclear physics research studies
- Particle accelerators and beam dynamics
- Atomic and Subatomic Physics Research
- Nuclear reactor physics and engineering
- Graphite, nuclear technology, radiation studies
- Radiation Effects and Dosimetry
- Ion-surface interactions and analysis
- Boron and Carbon Nanomaterials Research
- Fusion materials and technologies
- Laser-Plasma Interactions and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Particle Detector Development and Performance
- Particle Accelerators and Free-Electron Lasers
- Superconducting Materials and Applications
- Spacecraft and Cryogenic Technologies
- Nuclear Materials and Properties
- Medical Imaging Techniques and Applications
- Electron and X-Ray Spectroscopy Techniques
- Integrated Circuits and Semiconductor Failure Analysis
- Diamond and Carbon-based Materials Research
- Plant Micronutrient Interactions and Effects
Siberian Branch of the Russian Academy of Sciences
2014-2024
Budker Institute of Nuclear Physics
2015-2024
Novosibirsk State University
2014-2024
Boreskov Institute of Catalysis
2023
Russian Academy of Sciences
2012-2015
African Organisation for Research and Training in Cancer
2014
A compact accelerator-based neutron source has been proposed and created at the Budker Institute of Nuclear Physics in Novosibirsk, Russia. An original design tandem accelerator is used to provide a proton beam. The beam energy can be varied within range 0.6-2.3 MeV, keeping high-energy stability 0.1%. current also wide (from 0.3 mA 10 mA) with high (0.4%). In device, flux generated as result
Sufficient boron-10 isotope (10B) accumulation by tumor cells is one of the main requirements for successful boron neutron capture therapy (BNCT). The inability clinically registered 10B-containing borophenylalanine (BPA) to maintain a high concentration during irradiation after single injection has been partially solved its continuous infusion; however, lack persistence driven development new compounds that overcome imperfections BPA. We propose using elemental nanoparticles (eBNPs)...
Boron neutron capture therapy (BNCT) is one of the most appealing radiotherapy modalities, whose localization can be further improved by employment boron-containing nanoformulations, but fabrication biologically friendly, water-dispersible nanoparticles (NPs) with high boron content and favorable physicochemical characteristics still presents a great challenge. Here, we explore use elemental (B) NPs (BNPs) fabricated using methods pulsed laser ablation in liquids as sensitizers BNCT....
A vacuum-insulated tandem accelerator was used to observe in situ blistering during 2-MeV proton irradiation of metallic samples a fluence up 6.7 × 1020 cm−2. Samples consisting copper different purity, tantalum and tantalum-copper compounds were placed on the beam path forced cool. The surface state observed using charge-coupled device camera with remote microscope. Thermistors, pyrometer an infrared applied measure temperature irradiation. After irradiation, analyzed X-ray diffractometer,...
Boron carbide has been proposed for the neutron protection of equipment in ITER diagnostic ports and reducing dose to maintenance personnel. The chemical composition, vacuum, thermal properties ceramics boron were studied. It is demonstrated that outgassing rate meets requirements Vacuum Handbook. Calculation total gas emission from equatorial port #11 carried out. contact conductivity at boundary between bronze measured. Manganese content determined by method activation analysis ceramics....
A compact accelerator-based neutron source has been proposed and created at the Budker Institute of Nuclear Physics in Novosibirsk, Russia. An original design tandem accelerator is used to provide a proton beam. The flux generated as result 7Li(p,n)7Be threshold reaction using solid lithium target. beam shaping assembly applied convert this into epithermal neutrons with characteristics suitable for BNCT. BNCT technique being tested vitro vivo studies, dosimetry methods are developed....
Boron neutron capture therapy (BNCT) is an anticancer modality realized through 10B accumulation in tumor cells, irradiation of the tumor, and decay boron atoms with release alpha-particles lithium nuclei that damage cell DNA. As high-LET particle takes place inside cells absorbed dose calculations are difficult, since no essential extracellular energy emitted. We placed gold nanoparticles saturated to more accurately measure dose. T98G accumulated ~50 nm (AuNPs, 50 µg gold/mL)...
The accelerator based epithermal neutron source for Boron Neutron Capture Therapy (BNCT) is proposed, created and used in the Budker Institute of Nuclear Physics. In 2014, with support Russian Science Foundation BNCT laboratory purpose to end 2016 get flux, suitable BNCT. For getting 3 mA 2.3 MeV proton beam, was a new type - tandem vacuum isolation. On this moment, we have stationary beam current 1.75 mA. Generation neutrons carried out by dropping on lithium target as result threshold...
Abstract An intense epithermal neutron flux is necessary for boron capture therapy (BNCT), a promising technique the treatment of malignant tumors. The an essential characteristic BNCT beam and its measurement directly related to reliability planning system. Such tool could be cylindrical activation detector using 71 Ga(n, γ ) 72 Ga reaction. This paper describes made in likeness previously proposed one presents results numerical simulation sensitivity experimental use. notes difference...
A source of epithermal neutrons based on a tandem accelerator with vacuum insulation for boron neutron capture therapy malignant tumors was proposed and constructed. Stationary proton beam 2 MeV energy, 1.6 mA current, 0.1% energy monochromaticity 0.5% current stability has just been obtained.
A vacuum insulated tandem accelerator was used to study the effect of blistering on neutron yield under 2-MeV proton bombardment lithium target. The target is a thin layer evaporated onto an efficiently cooled copper substrate. Targets with thickness from 1 84 µm were irradiated by protons up fluence 6.3 1020 cm−2 which significantly greater than threshold. state targets surface observed using long-distance microscope, video camera, infrared camera. dose measured dosimeters, flux density...
In this study, we present results of initial trials a scintillator-over-fiber detector system with silicon photomultiplier readout designed at Budker Institute Nuclear Physics. The demonstrate that the proposed system, using pair boron-enriched and boron-free scintillators, could be successfully used for monitoring thermal neutron flux estimation irradiation dose. Nevertheless, it is necessary to optimize design head components ensure long time stability heavy radiation background.