A5014451852- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Pharmaceutical Economics and Policy
- Respiratory and Cough-Related Research
- Pharmacological Effects of Natural Compounds
- Health Systems, Economic Evaluations, Quality of Life
- Vitamin D Research Studies
- Pediatric health and respiratory diseases
- Digestive system and related health
- Pharmaceutical studies and practices
- Pneumonia and Respiratory Infections
- Veterinary medicine and infectious diseases
- Drug Solubulity and Delivery Systems
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Diet, Metabolism, and Disease
- Drug-Induced Hepatotoxicity and Protection
- Parathyroid Disorders and Treatments
- Healthcare Systems and Public Health
- Pharmacy and Medical Practices
- Pharmacogenetics and Drug Metabolism
Sechenov University
2002-2024
Ministry of Health of the Russian Federation
2017-2024
Institute of Professional Evaluation
2020-2022
Norwegian Center of Expertise
2020
INTRODUCTION . It is essential to monitor the efficacy and safety of medicinal products as part post-marketing surveillance identify, assess, prevent adverse drug reactions (ADRs). The effectiveness pharmacovigilance depends largely on healthcare professionals’ adherence requirements timeframes for reporting information regulatory authorities. AIM This study aimed identify systematise key aspects through an analysis experience in organising Moscow-based institutions 2018–2024 determine focus...
This compendium for gastroenterologists and hepatologists contains information about pH-sensitive polymers used in dosage forms oral administration delivery of drugs to certain parts the gastrointestinal tract. There is more here on pH-insensitive laxatives, hepatology antivirals rectal agents. also background chemical, spatial structure properties individual polymers, physiological basis their transformations under characteristics environment lumen These are aspects use targeted drug...
Background: The aim of this study was to determine the prevalence CYP2C9, VKORC1, CYP2C19, ABCB1, CYP2D6 and SLCO1B1 genes polymorphisms among residents Volga region (Chuvash Mari) northern Caucasus (Kabardins Ossetians). Materials & methods: involved 845 apparently healthy volunteers both sexes four different ethnic groups living in Russian Federation: 238 from Chuvash group, 206 Mari, 157 Kabardins 244 Ossetians. Results: Significant differences were identified allele frequency between...
Constipation, which is currently one of the global problems mankind, requires modern approaches to its pharmacological correction. Constipation that occurs in absence organic digestive pathology most cases considered a symptom functional constipation or irritable bowel syndrome, diagnosis based on compliance patient’s complaints and anamnestic data with Rome IV criteria for these disorders. Regulax Picosulphate, an intravenous droplet, laxative drug possibility precise easy dosing does not...
Widespread use of cephalosporin antibiotics in clinical practice calls for greater attention to the risk adverse drug reactions. Information on serious or unexpected events reported during post-marketing experience is submitted national and international pharmacovigilance databases. Analysis these reports helps identify new The aim study was analyse safety profile based spontaneous VigiBase database. Materials methods : analysis reaction MedDRA system organ classes included from moment its...
Chronic cerebral ischemia (CCI) is a common syndrome that, in the absence of adequate therapy, characterized by progressive course, an increase cognitive, emotional, motor and other disorders, eventually leading to persistent disability patient. In treatment patients with CCI, use drugs multimodal neuroprotective effect indicated. The results analysis series clinical trials Mexidol FORTE CCI are presented. effects relation asthenic, vegetative manifestations considered. It concluded that it...
The aim of the study is to evaluate clinical efficacy, safety, and impact complex metabolic neuroprotector on patients’ quality life (CMN) Cytoflavin in tablets, as well course stepwise pharmacotherapy patients with chronic cerebral ischemia (CCI) various etiologies, followed by meta-analysis, basis a systematic review published studies. Material methods. A selection randomized controlled trials was carried out over past 15 years, which CMN used tablet dosage form or therapy at least 25...
INTRODUCTION. Oral mesalazine (5-aminosalicylic acid) products are commonly used to treat inflammatory bowel disease, in particular, ulcerative colitis. The clinical efficacy of these medicinal depends directly on the composition and properties polymers deliver affected areas colon. However, information that has been accumulated date suggests release from enteric-coated dosage forms gastrointestinal tract simulations differs actual human tract, which necessitates further research. AIM. This...
Introduction . Xa factor inhibitors are a significant treatment option for patients with atrial fibrillation, as they assist in reducing the risk of stroke. However, there has not been enough research into levels X-factor these patients. Aim To assess impact blood clotting X on adverse drug events (ADEs) receiving apixaban or rivaroxaban treatment. Materials and methods The study involved 102 fibrillation who were administered inhibitors: 56 received 46 apixaban. Adverse reactions...
One of the serious problems during treatment osteoarthritis (OA) is developing adverse drug events therapy. Nonsteroidal anti - inflammatory drugs (NSAIDs) are first with high incidence and severity events. This article describes OA strategies approaches for presented using complex Alflutop, which has a composition similar to human hyaline cartilage. The analgesic effects, normalizes function affected joints, improves quality patients' life, also structure modifying effect. Such therapy...
The prevalence of GERD in most European countries and the Russian Federation is at level 15–20%. Hydrochloric acid plays a significant sometimes major role damage to mucosa upper gastrointestinal tract (GIT) patients with various acid-related diseases. Despite presence classes drugs that reduce damaging effect hydro-chloric on mucous membrane tract, diseases continues be an urgent medical problem. review article discusses issues pharmacological treatment Such as antacids, H2-histamine...
Helicobacter pylori infection can serve as one of indications to clarithromycin prescription. H. eradication is performed commonly a treatment for diseases caused by this pathogen and conditions with an increased risk complications (precancerous changes the gastric mucosa, unspecified iron deficiency anemia, idiopathic thrombocytopenic purpura, long-term NSAIDs use, anti-platelet drugs use etc). A number functional characteristics determines specific requirements schemes: high sensitivity...
Irritable bowel syndrome (IBS) is a common functional disease of the gastrointestinal tract, affecting large number adults worldwide, and leads to significant decrease in quality life. IBS places heavy burden on patients, most whom are able-bodied population, as well doctors healthcare system. The pathogenesis this multifactorial includes brain-intestine axis, disorders immune function mucous membrane, visceral hypersensitivity, changes motility microbial composition intestine. Based fact...
In this article we have described clinical pharmacology and data of studies an innovational drug valsartan + sacubitril in patients with chronic heart failure (CHF). The use supramolecular complex allows to elevate quality life improve prognosis CHF. High efficacy valsartan+sacubitril relative impact on composite primary end-point (cardiovascular death hospitalization due CHF) was demonstrated the trial PARADIGM-HF which it compared angiotensin converting enzyme inhibitor enalapril....
Onset of fever and pain syndrome in children is one the most frequent reasons parents take their to a paediatrician. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used relieve such symptoms. The mechanism action NSAIDs inhibit activity enzyme called cyclooxygenase (COX). Paracetamol, that COX, exerts its pharmacodynamic effect central nervous system, thereby providing antipyretic analgesic effects, but it ineffective stopping inflammation. Such common conditions as mild medium...
Nonsteroidal anti-inflammatory drug is one of the most commonly prescribed drugs for treatment inflammatory and pain syndromes in clinical practice doctors various specialties. The popularity this pharmacological group increasing due to over-the-counter dispensing condition, but at same time, significance issues likelihood, prevention severe adverse reactions during intake that controlled uncontrolled by medical personnel increasing. This review devoted issue non-steroidal drug-induced...