A5034310309- Iron Metabolism and Disorders
- Characterization and Applications of Magnetic Nanoparticles
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Quantum Dots Synthesis And Properties
- Advanced Glycation End Products research
- RNA Interference and Gene Delivery
- Ocular Surface and Contact Lens
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Metal-Organic Frameworks: Synthesis and Applications
- Corneal Surgery and Treatments
- Advanced Nanomaterials in Catalysis
Engelhardt Institute of Molecular Biology
2020-2022
Institute of Physics and Technology
2022
Moscow Institute of Physics and Technology
2022
Sirius University of Science and Technology
2020
Magnetic nanoparticles are widely used in biomedicine for MRI imaging and anemia treatment. The aging of these nanomaterials vivo may lead to gradual diminishing their contrast properties inducing toxicity. Here, we describe observation the full lifecycle 40-nm magnetic particles from injection complete degradation associated impact on organism. We found that 2 h were eliminated bloodstream, but initial biodistribution changed over time. In 1 week, a major part was transferred liver spleen,...
Abstract The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure. Here, human contact lenses are modified with highly porous metal‐organic frameworks sustained release brimonidine for prolonged treatment. Various were screened their attachment lenses, loading brimonidine, and drug‐release properties. Optimized therapeutic ocular conjugated MIL‐101(Cr) maintain optical transparency power. Coating nanoparticles reduced washout tears ensured a...
Methods for the synthesis of biocompatible and highly luminescent quantum dots are presented. Desirable spectral characteristics were achieved by fine tuning reaction parameters. To obtain nanoconstructions functionalized with a number biomolecules, synthesized materials tested in vitro. Obtained results could be useful both basic applied research which bioimaging methods used.
Nanoparticles are convenient instruments for different biomedical applications. Using hybrid nanomaterials with multimodal features allow designing advanced agents targeted drug delivery and bioimaging. Here we constructed magnetic metal-organic framework nanoparticles optimized to transport small oligonucleotides act as perspective nanoagents fluorescent bioimaging MRI-contrasting. Further, the achieved combination of optical high adsorption capacity is promising construction novel types...
Abstract Magnetic nanoparticles are widely used in biomedicine for MRI imaging and anemia treatment. The aging of these nanomaterials vivo may lead to gradual diminishing their contrast properties inducing toxicity. Here we describe observation the full lifecycle 50-nm magnetic particles from injection complete degradation associated impact on organism. We found that 2 hours were eliminated bloodstream, but initial biodistribution changed over time. In 1 week major part was transferred liver...
Gene therapy is on the cutting edge of modern medicine, thus delivery gene interest (GOI) an ongoing challenging task. Here, we performed optimization synthesis polymer-coated metal-organic frameworks with magnetic core, aiming to improve their ability be nucleic acid carriers. We varied different parameters investigate impact DNA-binding capacity as well certain nanoparticles a vehicle for in vitro transfection.