A5048573253- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Iron Metabolism and Disorders
- Geomagnetism and Paleomagnetism Studies
- Lung Cancer Research Studies
- Advanced biosensing and bioanalysis techniques
- Magnetic and Electromagnetic Effects
- Metal-Organic Frameworks: Synthesis and Applications
- Peptidase Inhibition and Analysis
- Carbon and Quantum Dots Applications
- Immunotherapy and Immune Responses
- Material Properties and Applications
- Dendrimers and Hyperbranched Polymers
- AI-based Problem Solving and Planning
- Spaceflight effects on biology
- Neuroendocrine Tumor Research Advances
- CAR-T cell therapy research
- Machine Learning and Algorithms
- Microfluidic and Bio-sensing Technologies
- Nanocluster Synthesis and Applications
- Drug Solubulity and Delivery Systems
- MXene and MAX Phase Materials
Aristotle University of Thessaloniki
2024-2025
Harvard University
2022-2025
Brigham and Women's Hospital
2022-2025
G. Papanikolaou General Hospital
2024
Institute of Bioorganic Chemistry
2018-2024
Moscow Institute of Physics and Technology
2018-2022
Institute of Physics and Technology
2020
Institute of Bioorganic Chemistry
2018
New York State Department of Labor
2018
Russian Academy of Sciences
2018
RBC-hitchhiking regime is shown without prolongation of nanoparticle blood circulation but with the record 120-fold boost particle delivery to lungs. The approach efficient for treatment pulmonary metastases.
Safe application of nanoparticles in medicine requires full understanding their pharmacokinetics including catabolism the organism. However, information about nanoparticle degradation is still scanty due to difficulty long-term measurements by invasive techniques. Here, we describe a magnetic spectral approach for vivo monitoring particle (MP) degradation. The method noninvasiveness has allowed performing broad comprehensive study 1-year fate 17 types iron oxide particles. We show...
Magnetic nanoparticles are widely used in biomedicine for MRI imaging and anemia treatment. The aging of these nanomaterials vivo may lead to gradual diminishing their contrast properties inducing toxicity. Here, we describe observation the full lifecycle 40-nm magnetic particles from injection complete degradation associated impact on organism. We found that 2 h were eliminated bloodstream, but initial biodistribution changed over time. In 1 week, a major part was transferred liver spleen,...
Abstract The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure. Here, human contact lenses are modified with highly porous metal‐organic frameworks sustained release brimonidine for prolonged treatment. Various were screened their attachment lenses, loading brimonidine, and drug‐release properties. Optimized therapeutic ocular conjugated MIL‐101(Cr) maintain optical transparency power. Coating nanoparticles reduced washout tears ensured a...
ABSTRACT Carbon quantum dots (CQDs) represent a rapidly emerging class of nanomaterials with significant potential in biomedical applications due to their tunable fluorescence, high biocompatibility, and versatile functionalization. This review focuses on the recent progress utilizing CQDs for drug delivery, bioimaging, biosensing, cancer therapy. With unique optical properties, such as yield, photostability, enable precise bioimaging sensitive biosensing. Their small size, ease surface...
Lung cancer is a leading cause of cancer-related deaths globally, includes small cell lung (SCLC), characterized by its aggressive nature and advanced disease at diagnosis. However, the identification reliable biomarkers for SCLC has proven challenging, as no consistent predictive biomarker been established. Nonetheless, certain tumor-associated antigens, including programmed death-ligand 1 (PDL1) Delta-Like Ligand 3 (DLL3), show promise targeted antibody-based immunotherapy. To ensure...
Nanoparticles (NPs) are among the most promising agents for advanced theranostics. However, their functioning in vivo is severely inhibited by mononuclear phagocyte system (MPS), which rapidly removes all foreign entities from blood circulation. Little known about sequestration mechanisms and ways to counteract them. New methods highly demanded investigation with high scrutiny of each aspect NP clearance blood. For example, while liver macrophages capture majority administered particles,...
Magnetogenetics emerges as a transformative approach for modulating cellular signaling pathways through the strategic application of magnetic fields and nanoparticles. This technique leverages unique properties nanoparticles (MNPs) to induce mechanical or thermal stimuli within cells, facilitating activation mechano- thermosensitive proteins without need traditional ligand-receptor interactions. Unlike modalities that often require invasive interventions lack precision in targeting specific...
Abstract Cancer immunotherapy has revolutionized cancer treatment by leveraging the immune system to target and eliminate tumor cells. Implantable biomaterials, such as hydrogels, sponges, scaffolds, implantable microdevice platforms, macrobeads, offer localized sustained release of immunomodulatory agents, improving delivery treatments checkpoint inhibitors, vaccines, adoptive cell therapies like CAR‐T This review examines emerging role these biomaterials in modulating microenvironment,...
Nanocomposite materials are of great interest as a multipurpose instrument for various biomedical applications. In the presented work, we demonstrate capability fluorophore-modified nanoparticles based on iron oxides and oxyhydroxides crystallites to act multimodal agents that combine specific recognition target cells with properties used fluorescent bioimaging MRI-contrasting.
Abstract A structure as well a specific electrical resistance of scandium films having various thickness (300 up to 2800 Å) obtained at condensation rate: w ⋍ 1 155 Å/s have been studied in the present work. Depending on conditions hydride ScH x , h.c.p. — Sc, or + Sc alternatively, is formed, phase containing distorted hexagonal lattice evolving into over period few hours. The and h.c.p‐Sc change 2 O 3 when annealed vacuum 5 · 10 −5 Torr T ≈ 800°C, while −8 h.c.p.‐Sc with negligible...
Abstract Hereditary angioedema (HAE) is a complex genetic disorder characterized by recurrent episodes of localized skin and mucosal swelling, with potential life-threatening complications, particularly in the upper respiratory tract. While much understood about mutations behind HAE I-II types, landscape type III remains complex. Our study provides comprehensive exploration an undiagnosed case 13-year-old female presenting symptoms. Despite undergoing thorough clinical evaluations including...