A5053990633- Lipoproteins and Cardiovascular Health
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Phytochemistry and biological activities of Ficus species
- Diabetes, Cardiovascular Risks, and Lipoproteins
- High Altitude and Hypoxia
- Spaceflight effects on biology
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin C and Antioxidants Research
- Lipid metabolism and disorders
- Bone Metabolism and Diseases
- Natural Compound Pharmacology Studies
- Ginger and Zingiberaceae research
- Cardiovascular Disease and Adiposity
- Cholesterol and Lipid Metabolism
- Estrogen and related hormone effects
- Phytochemicals and Antioxidant Activities
- Nigella sativa pharmacological applications
- Climate Change and Health Impacts
- Coronary Interventions and Diagnostics
- Effects and risks of endocrine disrupting chemicals
- Vitamin K Research Studies
- Biomarkers in Disease Mechanisms
- Phytoestrogen effects and research
Universiti Teknologi MARA
2014-2024
Hospital Sungai Buloh
2014-2024
University of Malaya
2023
Sunway University
2023
Thang Long University
2023
European Atherosclerosis Society
2021
Faculty (United Kingdom)
2014
Ministry of Agriculture, Livestock, and Food Supply
2013
University Kebangsaan Malaysia Medical Centre
2004
National University of Malaysia
2003
Hyperlipidaemia is a major risk factor for cardiovascular disease (CVD) due to its role in forming atherosclerotic plaques. Finding natural products with anti-hyperlipidaemic properties important preventing atherosclerosis. Ficus deltoidea var kunstleri extract (FDK) traditionally used regulate blood glucose and pressure, however effect on lowering lipid scarce. Previous study showed neutral effects of FDK lipids. Hydrogel delivery commonly enhance absorption active compounds therefore...
Despite reports on the efficacy of proprotein convertase subtilisin-Kexin type 9 (PCSK9) inhibitors as a potent lipid-lowering agent in various large-scale clinical trials, anti-atherogenic properties PCSK9 reducing and atherogenesis biomarkers via NF-ĸB eNOS pathway has yet to be established. This study aimed investigate effects PCSK9, targeted early biomarkers, monocyte binding stimulated human coronary artery endothelial cells (HCAEC). HCAEC were with lipopolysaccharides (LPS) incubated...
Familial hypercholesterolaemia (FH) is a genetic disorder with high risk of developing premature coronary artery disease that should be diagnosed as early possible. Several clinical diagnostic criteria for FH are available, the Dutch Lipid Clinic Criteria (DLCC) being widely used. Information regarding performances other against DLCC scarce. We aimed to examine performance Simon-Broom (SB) Register criteria, US Make Early Diagnosis Prevent Deaths (US MEDPED) and Japanese Management (JFHMC)...
Metabolic syndrome is a non-communicable disease inclusive of risk factors such as central obesity, hypertension, hyperglycaemia and dyslipidaemia. In this present study, we investigated the ability Pandanus amaryllifolius (PA) leaf water extract to reverse cluster diseases in an established rat model induced by fructose drinking water. Thirty healthy adult male Wistar rats (150–180 g) were randomly divided into three groups which included control (C; n = 6), PA (PAE; 6) Syndrome (MetS; 18)....
Background: Tocotrienols (TCTs) are more potent antioxidants than α-tocopherol (TOC). However, the effectiveness and mechanism of action TCT isomers as anti-atherosclerotic agents in stimulated human endothelial cells under inflammatory conditions not well established.Aims: 1) To compare effects different on inflammation, activation, nitric oxide synthase (eNOS). 2) identify two most cells. 3) investigate NFκB protein gene expression levels cells.Methods: Human umbilical vein were incubated...
Abstract Background Ficus deltoidea (FD) has been shown to have antidiabetic, anti-inflammatory, antinociceptive and antioxidant properties. However, its effects on key events in the pathogenesis of atherosclerosis are unknown. Aim To investigate endothelial activation, inflammation, monocyte-endothelial cell binding oxidative stress four FD varieties. Methods Human coronary artery cells (HCAEC) were incubated with different concentrations aqueous ethanolic extracts var. trengganuensis...
Background: Atherosclerosis is the main cause of coronary artery disease -related deaths worldwide. The atheroprotective properties pure tocotrienols (T3) in absence alpha-tocopherol (α-TCP) vitamin E has not been extensively examined.Aim: To determine T3 early and established atherosclerosis rabbits.Methods: Thirty New Zealand white rabbits were divided into two groups, B1 B2 which represent [fed 1% high cholesterol diet (HCD) for 2 weeks] (fed HCD 8 weeks) atherosclerosis. Each group was...
The role of oxidized high- density lipoprotein (oxHDL) and the protective effects adiponectin in terms vascular calcification is not well-established. This study was conducted to investigate oxHDL with regard inflammation determine attenuating detrimental oxHDL. Cell viability, mineralization, assays were optimize concentration Then, human smooth muscle cells (HAoVSMCs) incubated β-glycerophosphate, HDL, oxHDL, adiponectin, or combination for 24 h. Protein expression IL-6, TNF-α, osterix,...
Wound healing is a complex and dynamic cellular process to restore tissue function. Current treatments for chronic wounds especially diabetic ulcers are expensive, with adverse effects. Recently, numerous researchers have focused on the potential effect of natural products wound healing. One them mangosteen (Garcinia mangostana Linn). It well-known tropical fruit that native Southeast Asia. The active ingredient pericarp contains xanthones exhibit wide range pharmacological activities,...
Low mineralization activity by human osteoblast cells (HOBs) indicates abnormal bone remodeling that potentially leads to osteoporosis. Oxidation, the most prominent form of high-density lipoprotein (HDL) modification, is suggested affect through inflammatory pathway. Adiponectin, which possesses anti-inflammatory activity, postulated have ability suppress detrimental effects oxidized HDL (oxHDL). This study aimed investigate before and after oxidation on markers inflammation. The protective...
Since bisphenol A (BPA) induces bone loss and phytoestrogens enhance the osteoblastogenesis by binding to non-classical classical oestrogen receptors, respectively, present study was aimed observe osteoprotective effect of on BPA-induced osteoblasts in hFOB 1.19 cells. All groups cells were induced with 12.5 μg/ml BPA except control (Ctrl) group. Meanwhile, treated received phytoestrogens; Daidzein (Dz), Genistein (Gt), Equol (Eq) 17β-oestradiol (Est) different concentrations for 24 hr...
Background: Various methods were used to induce atherosclerosis in rabbits. One of the most common is high-cholesterol diet (HCD) feeding. However, exact amount and duration HCD feeding early established New Zealand white rabbits (NZWR) continue be debated among researchers. Therefore, this study aims evaluate effectiveness 1% inducing lesions NZWR. Methods: A total 50 g/kg/day was fed three four months old male weighing 1.8 2.0 kg for eight weeks respectively. The body weight lipid profile...
The role of HDL in reverse cholesterol transport is well known but other atheroprotectivemechanism, e.g. antioxidant capacities not clear. aim this study todetermine the effects different doses on activities assay. wasisolated from plasma by single step-ultracentrifugation. activity differentdoses were measured ferric thiocyanate (FTC), 2,2-diphenyl-1-picrylhydrazyl(DPPH) and dichlorofluorescein (DCF) tests. Coincubation with LDL showed longerlag time lower reaction rate a dose-dependent...