A5060975101- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Saffron Plant Research Studies
- Phytochemistry and biological activities of Ficus species
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipid metabolism and disorders
- Phytochemical and Pharmacological Studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Risk Factors
- Autopsy Techniques and Outcomes
- Cholesterol and Lipid Metabolism
- Pharmaceutical Practices and Patient Outcomes
- Ginger and Zingiberaceae research
- Flavonoids in Medical Research
- Hemoglobinopathies and Related Disorders
- Hormonal Regulation and Hypertension
- Graphene and Nanomaterials Applications
- Global Public Health Policies and Epidemiology
- Nitric Oxide and Endothelin Effects
- Tea Polyphenols and Effects
- Health Promotion and Cardiovascular Prevention
- Acute Kidney Injury Research
- Imbalanced Data Classification Techniques
Universiti Teknologi MARA
2016-2025
Hospital Sungai Buloh
2017-2025
King Faisal University
2024
European Atherosclerosis Society
2021
University of Malaya
2012
University of Oxford
2001
Cataracts are significant causes of blindness, closely linked to prolonged hypercholesterolemia. While saffron has the potential for eye health, its effects on lens lesions remain understudied. This study aimed investigate effect changes in atherosclerotic-induced New Zealand white rabbits (NZWR). Thirty-five NZWRs were subjected four eight weeks high-cholesterol diet induce atherosclerosis, resulting cataractous changes. The categorised randomly into three groups: normal group, pre-treated...
Hyperlipidaemia is a major risk factor for cardiovascular disease (CVD) due to its role in forming atherosclerotic plaques. Finding natural products with anti-hyperlipidaemic properties important preventing atherosclerosis. Ficus deltoidea var kunstleri extract (FDK) traditionally used regulate blood glucose and pressure, however effect on lowering lipid scarce. Previous study showed neutral effects of FDK lipids. Hydrogel delivery commonly enhance absorption active compounds therefore...
Familial hypercholesterolaemia (FH) is the most common autosomal dominant lipid disorder, leading to severe hypercholesterolaemia. Early detection and treatment with lipid-lowering medications may reduce risk of premature coronary artery disease in FH patients. However, there scarcity data on prevalence, rate, control therapy Malaysian community.Community participants (n=5130) were recruited from all states Malaysia. Blood samples collected for profiles glucose analyses. Personal family...
Familial hypercholesterolaemia (FH) is a genetic disorder with high risk of developing premature coronary artery disease that should be diagnosed as early possible. Several clinical diagnostic criteria for FH are available, the Dutch Lipid Clinic Criteria (DLCC) being widely used. Information regarding performances other against DLCC scarce. We aimed to examine performance Simon-Broom (SB) Register criteria, US Make Early Diagnosis Prevent Deaths (US MEDPED) and Japanese Management (JFHMC)...
Cardiovascular disease (CVD) has been a burden to many developing countries for decades, including Malaysia. Although various steps have taken prevent and manage CVD, it remains the leading cause of morbidity mortality. The rising prevalence CVD risk factors such as hypertension, hypercholesterolaemia, diabetes, overweight obesity is main driving force behind epidemic. Therefore, nationwide health study coined Malaysian Health Wellbeing Assessment (MyHEBAT) was designed. It aimed investigate...
Abstract Background Ficus deltoidea (FD) has been shown to have antidiabetic, anti-inflammatory, antinociceptive and antioxidant properties. However, its effects on key events in the pathogenesis of atherosclerosis are unknown. Aim To investigate endothelial activation, inflammation, monocyte-endothelial cell binding oxidative stress four FD varieties. Methods Human coronary artery cells (HCAEC) were incubated with different concentrations aqueous ethanolic extracts var. trengganuensis...
Abstract Background Primary care physicians (PCP) play an important role in detecting Familial Hypercholesterolaemia (FH) early. However, knowledge, awareness and practice (KAP) regarding FH among Malaysian PCP are not well established, there was no validated tool to assess their KAP. Thus, the aim of this study adapt KAP questionnaire determine its validity reliability PCP. Methods This cross-sectional validation involved with ≥ 1-year work experience primary settings. In Phase 1, original...
Background Familial hypercholesterolaemia (FH) patients have elevated levels of low-density lipoprotein cholesterol, rendering them at high risk premature coronary artery disease (PCAD). However, the FH prevalence among angiogram-proven PCAD (AP-PCAD) and their status factors (CRFs) not been reported in Asian population. Objectives This study aimed to (1) determine clinically diagnosed AP-PCAD patients, (2) compare CRFs between with control groups, (3) identify independent predictors PCAD....
Familial hypercholesterolaemia (FH) is caused by mutations in lipid metabolism genes, predominantly low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), proprotein convertase subtilisin/kexin-type 9 (PCSK9) and LDL adaptor protein 1 (LDLRAP1). The prevalence of genetically confirmed FH the detection rate pathogenic variants (PV) amongst clinically diagnosed patients not well established. Targeted next-generation sequencing LDLR, APOB, PCSK9 LDLRAP1 was performed on 372 Malaysian...
Previous research has shown that natural medications pose health risks, especially in subjects with comorbidities. This study aimed to evaluate the safety of saffron ethanolic extract (SEE) administration early and established atherosclerotic rabbits. Rabbits were given a high-cholesterol diet (HCD) for 4 8 weeks induce atherosclerosis respectively, then they treated 50 100 mg/kg/day SEE. The body weight animals was recorded. Blood samples collected at baseline, pre-treatment, post-treatment...
Background Familial hypercholesterolemia (FH) is predominantly caused by mutations in the 4 FH candidate genes (FHCGs), namely, low-density lipoprotein receptor (LDLR), apolipoprotein B-100 (APOB-100), proprotein convertase subtilisin/kexin type 9 (PCSK9), and LDL adaptor protein 1 (LDLRAP1). It characterized elevated cholesterol (LDL-c) levels leading to premature coronary artery disease. can be clinically diagnosed using established clinical criteria, Simon Broome (SB) Dutch Lipid Clinic...
Despite its rarity and sporadic occurrence, methanol poisoning may result in devastating consequences to the victims including death. We report a series of cases following an outbreak Klang Valley, Malaysia. Victims were presented as either brought-in-dead or died during hospitalization. Medico-legal autopsy was performed at Department Forensic Medicine, Hospital Sungai Buloh all cases. sought establish epidemiology, survival period, level methanol, autopsy, neuropathology findings Sixteen...
Background: Various methods were used to induce atherosclerosis in rabbits. One of the most common is high-cholesterol diet (HCD) feeding. However, exact amount and duration HCD feeding early established New Zealand white rabbits (NZWR) continue be debated among researchers. Therefore, this study aims evaluate effectiveness 1% inducing lesions NZWR. Methods: A total 50 g/kg/day was fed three four months old male weighing 1.8 2.0 kg for eight weeks respectively. The body weight lipid profile...
Dyslipidaemia is a major cause of morbidity and mortality. The aims this study are to determine the prevalence dyslipidaemia subtypes, proportions lipid-lowering therapy (LLT) use, achievement low-density lipoprotein cholesterol (LDL-C) treatment targets for high-risk (HR) very (VHR) Malaysians. This cross-sectional involves 5279 participants across 11 states in Malaysia. data were obtained through standardised questionnaire, anthropometric measurements, venous glucose lipid profile. with...
The recent healthcare transformations emphasize the importance of individuals maintaining a healthy lifestyle through proper nutrition and physical activity to reduce risk severe illnesses. Patients often search for information on their own, leading uncertainty about appropriate diets or fitness activities. Consequently, many cross-check health advice from various sources. However, some people hesitate verify online health-related with clinicians, fearing that it may be perceived as...