A5067205074- Liquid Crystal Research Advancements
- Natural Compound Pharmacology Studies
- Glycosylation and Glycoproteins Research
- Surfactants and Colloidal Systems
- Food Chemistry and Fat Analysis
- Chemotherapy-induced organ toxicity mitigation
- Nigella sativa pharmacological applications
- Polysaccharides and Plant Cell Walls
- Wound Healing and Treatments
- TiO2 Photocatalysis and Solar Cells
- Andrographolide Research and Applications
- Nanoparticles: synthesis and applications
- Carbohydrate Chemistry and Synthesis
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Lipid Membrane Structure and Behavior
- Paraoxonase enzyme and polymorphisms
- Mangiferin and Mango Extracts
- Graphene and Nanomaterials Applications
Hospital Sungai Buloh
2023-2024
Universiti Teknologi MARA
2022-2024
University of Malaya
2016-2023
Sunway University
2023
Thang Long University
2023
Inverse bicontinuous cubic phases of lyotropic liquid crystal self-assembly have received much attention in biomedical, biosensing, and nanotechnology applications. An Ia3d based on the gyroid G-surface can be formed by Guerbet synthetic glucolipid 2-hexyl-decyl-β-d-glucopyranoside (β-Glc-OC6C10) excess water. The small water channel diameter this phase could provide nanoscale constraints encapsulation large molecules crystallization membrane proteins, hence stresses importance tuning...
Using mannose as the sugar head, five Guerbet glycolipids with chain ranges from C8 to C24 were synthesised and studied for their liquid crystal behaviour. Differential scanning calorimetry, optical polarising microscopy small-angle X-ray scattering employed determine thermal, phase structure properties. Unlike monoalkylated glycolipids, these mannosides showed a glass transition below 0°C, except α-Man-OC14C10. In dry state, lamellar was observed α-Man-OC6C2 α-Man-OC8C4, while α-Man-OC12C8...
Wound healing is a complex and dynamic cellular process to restore tissue function. Current treatments for chronic wounds especially diabetic ulcers are expensive, with adverse effects. Recently, numerous researchers have focused on the potential effect of natural products wound healing. One them mangosteen (Garcinia mangostana Linn). It well-known tropical fruit that native Southeast Asia. The active ingredient pericarp contains xanthones exhibit wide range pharmacological activities,...
The lyotropic phase behavior of four common and easily accessible glycosides, n-octyl α-d-glycosides, namely, α-Glc-OC8, α-Man-OC8, α-Gal-OC8, α-Xyl-OC8, was investigated. presence normal hexagonal (HI), bicontinuous cubic (VI), lamellar (Lα) phases in α-Glc-OC8 α-Man-OC8 including their diagrams water reported previously verified by deuterium nuclear magnetic resonance (2H NMR), via monitoring the D2O spectra. Additionally, partial binary liquid crystal structures formed α-Gal-OC8 α-Xyl-OC8...
Hyperhomocysteinemia causes endoplasmic reticulum (ER) stress, which elevates reactive oxygen species (ROS) and induces endothelial dysfunction, the hallmark of cardiovascular diseases. Nigella sativa seeds contain thymoquinone (TQ), a cardioprotective bioactive component. Nevertheless, research on investigating effectiveness TQ in preventing dysfunction caused by homocysteine (Hcy) is scarce. Therefore, purpose this work was to examine role restoring Hcy-induced as well mechanisms behind...
Diabetic wounds are particularly difficult to treat medically because they heal at a slower pace than regular wounds. Macrophages essential in all stages of normal wound healing, including inflammation, proliferation and rem odelling. When healing is affected, macrophages can reduce the level growth factor increase interleukin-6 (IL-6), disrupt balance between tissue inhibitors metalloproteinase (TIMPs) matrix (MMPs), which slow down healing. Alpha(α)-mangostin, natural xanthone derived from...
Abstract Hyperhomocysteinemia has been linked to an increased risk of cardiovascular diseases. High levels homocysteine (Hcy) promote endoplasmic reticulum (ER) stress that can increase reactive oxygen species (ROS), leading endothelial dysfunction. Thymoquinone (TQ) is the major active ingredient in Nigella sativa seeds volatile oil and shown have a cardioprotective effect. However, no study evaluated effect TQ against Hcy-induced Thus, this aims investigate effects mechanisms reversing...
Abstract Poor wound healing is a common manifestation of diabetes mellitus, culminating in chronic, non-healing ulcer. Alpha(α)-mangostin, one the most active xanthones found mangosteen pericarp, has been reported to promote healing. However, its effectiveness and mechanism expediting diabetic unknown. The aim this study was investigate effect alpha-mangostin on cell migration growth factor expressions model. Human coronary artery endothelial cells (HCAEC) human dermal fibroblast (HDF) were...