This study aimed to examine the impact of BPA exposure on pregnancy and foetuses cardiac tissues expression microRNAs (miRNAs) related heart development diseases. Pregnancy is known be "critical windows" in determining offspring physical cells their life after birth. The increment risk cardiovascular disease (CVD) a later stage has been reported by few studies demonstrated from prenatal BPA. shown alter miRNAs profiles for organ development, regeneration metabolic functions. These...

Chronic uncontrolled hyperglycaemia leads to increased oxidative stress and lipid peroxidation resulting in vascular complications accelerates the progression of diabetic atherosclerosis. Though varieties modern drugs used treatment diabetes, diabetes are increasing. Naringenin (NG), has been reported have potent antioxidant anti-atherosclerotic properties. However, effects NG as vasculoprotective agent prolonged not well documented. Thus, this study was aimed determine effect against...

Cancer recurrence is often associated with the acquisition of radioresistance by cancer tissues due to failure in radiotherapy. The underlying mechanism leading development acquired EMT6 mouse mammary carcinoma cell line and potential pathway involved was investigated comparing differential gene expressions between parental cells. exposed 2 Gy/per cycle gamma-ray survival fraction EMT6-treated cells compared. EMT6RR_MJI (acquired radioresistance) developed after 8 cycles fractionated...

Since bisphenol A (BPA) induces bone loss and phytoestrogens enhance the osteoblastogenesis by binding to non-classical classical oestrogen receptors, respectively, present study was aimed observe osteoprotective effect of on BPA-induced osteoblasts in hFOB 1.19 cells. All groups cells were induced with 12.5 μg/ml BPA except control (Ctrl) group. Meanwhile, treated received phytoestrogens; Daidzein (Dz), Genistein (Gt), Equol (Eq) 17β-oestradiol (Est) different concentrations for 24 hr...

Abstract The aim of the study was to investigate location motor neuron somata geniohyoid muscle in rat. Nine Sprague‐Dawley rats were used this study. Operations performed under general anaesthesia. Nembutal sodium, 40 mg per kg intraperitoneally for 0.02 0.05 ml 30% horseradish peroxidase (Sigma Type VI ) solution normal saline injected into exposed right muscle. After 48 hr, animals fixed by perfusion through left ventricle heart, first 100 and then with 500 1.25% glutaraldehyde 1%...

Bisphenol A (BPA) has been utilised excessively at a global capacity of 2.9 billion kg/year. It is widely used in manufacturing polycarbonate polymers and epoxy resins. Hence, humans are potentially exposed to this chemical substance their daily life. As typical endocrine disruptor, BPA exhibits detectable hormone-like properties. Many studies have linking exposure with the risk developing cardiovascular disease, however direct on cardiomyocytes beating rates morphology not entirely...

Abstract We presented a development of custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate (Pb) (ii) optimize mice-bearing tumour model with 2 8 Gy absorbed doses. The shielding fabricated cuboid shape canal on top hole vertical side beam path. Respective deliveries doses 28 75 were used achieve at sites.

Introduction: The interaction between the T cell immune checkpoint proteins, programmed death-1 (PD-1) receptor, and its ligand PD-L1 plays a crucial role in suppression evasion of cancer cells from detection, thereby promoting tumour growth. Nivolumab, PD-1 inhibitor, disrupts this interaction, offering potential therapeutic anti-cancer strategy. goals study were to identify optimal dosage nivolumab that effectively decreases protein expression mouse model, examine impact on Methods: We...

Introduction: Studies over the past decades reveal global decline of sperm quality among unselected men, particularly in its concentration. The impacts exercise on are still ambiguous. This study aims to analyze effects different intensities testicular malondialdehyde (MDA), caspase-3, and mice. might result recommendation intensity that improves protects quality. Methods: Male Deutschland–Denken–Yoken mice were divided into four groups: a control group three intervention groups with loads...

Targeting the activation of immune checkpoints is recognized as an effective strategy for triggering anti-tumour responses in cancer cells. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) were identified potential crucial targets treatment. Overexpression CTLA-4 PD-1 proteins primary tumour human lines well documented. In contrary, lack data was available using animal lines. The presence study aims to optimize expression EMT6 mouse mammary cells...

A complicated interplay between radiation doses, tumour microenvironment (TME), and host immune system is linked to the active participation of response.The effects single targeted 2 Gy 8 gamma-ray irradiations on cell population (lymphocytes, B-cells, T-cells, neutrophils, eosinophils, macrophages) in EMT6 mouse-bearing models was investigated.The both irradiation doses early (96 hours) acute phase (5 11 days) post-irradiation parameters were monitored blood circulation TME using flow...

Biceps brachii (BB) is one of the muscles which are subjected to many variations.Recently, there a lot information about variations in origin but also some cases reported on insertion BB.Presented herein was case BB muscle having both variant and same muscle.The long large at its third head (10.2 cm width 4.9 breadth) arises from mid-shaft humerus.More significantly, medial

Presented herein is a case of one different morphological anomaly pronator quadratus (PQ) muscle.Here, the shape PQ was not similar to normal morphology muscle.The muscle appeared be in distinct triangularshaped instead quadrangular-shaped.In addition, this triangular-shaped found two sites i.e. proximal and distal.Significantly, consisted

We presented a flow cytometry protocol to isolate and measure the cellular component of tumour immune microenvironment (TIME) mice bearing breast cancer models. The cells infiltrating (TME) have been getting more attention as determination their pro- or/and anti-tumorigenic activity contributes treatment success. In addition, our group has strong interest investigate infiltration eosinophils within TME tumorigenic role is still unclear. This study aims TME, including using with 6-colour...