A5066318684- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- Lipid Membrane Structure and Behavior
- Bacterial Identification and Susceptibility Testing
- Probiotics and Fermented Foods
- Bacterial biofilms and quorum sensing
- RNA and protein synthesis mechanisms
- Chemical and Physical Studies
- Erythrocyte Function and Pathophysiology
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Medical and Biological Ozone Research
- Oral microbiology and periodontitis research
- Historical Medical Research and Treatments
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Gut microbiota and health
- Streptococcal Infections and Treatments
- Dermatology and Skin Diseases
- HIV, TB, and STIs Epidemiology
- IL-33, ST2, and ILC Pathways
- Viral gastroenteritis research and epidemiology
- Celiac Disease Research and Management
Sechenov University
2016-2023
Introduction. Influenza is an acute respiratory viral infectious disease caused by the influenza viruses. Current preventive and therapeutic approaches are of great anti-epidemic importance, but there a number problems, such as rapid emergence resistant strains, lack cross-immunity effectiveness vaccines. One to development anti-influenza agents use RNA interference small interfering RNAs complementary mRNA target cellular genes. Aim ‒ evaluate prophylactic effect siRNAs directed genes NXF1,...
The SARS-CoV-2 virus is a pathogen causing the coronavirus infection that culminated in worldwide pandemic 2020. It belongs to β-coronaviruses and has high genetic similarity SARS-CoV responsible for an outbreak of severe acute respiratory syndrome 2002–2003. analysis molecular interactions shows higher virulence due lower binding free energy interaction with angiotensin-converting enzyme 2 (ACE2), which used by enter host cell. At time global pandemic, thorough study ACE2 as key component...
Background: Influenza is one of the most common infectious diseases, which affect lower respiratory tract, and can lead to serious complications including death. It known that currently available therapeutic agents vaccines do not provide 100% protection against influenza viruses. The development drugs based on RNA interference mechanism in context this problem a promising area. This paper aims assess effect FLT4, Nup98, Nup205 cellular gene knockdown reproduction A virus human lung cell...
Microfold cells (M cells) are specialized intestinal epithelial that initiate mucosal immune responses. These unique phagocytic for the transfer of a broad range particulate antigens and microorganisms across follicle-associated epithelium (FAE) into gut-associated lymphoid tissue (GALT) by process termed transcytosis. The molecular basis antigen uptake M has been gradually identified in last decade. Active sampling initiates regulated responses ensure homeostasis. delivery luminal...
Relevance. Vaccination remains the basis for prevention of most severe infectious diseases, including influenza. The large number vaccines have been developed and applied currently. role adjuvant is growing. Aims: To look back to history review literature on clinical trials influenza Grippol family. Conclusions: This summarized principal data adjuvanted containing Polyoxidonium as which has used production family more than 22 years. show a high safety profile good immunogenicity vaccineers,...
Objectives. To evaluate the effect of cellular genes FLT4, Nup98, and Nup205 on reproduction influenza A virus in A549 human lung cancer cell line. Methods. The work was carried out using equipment center for collective use I.I. Mechnikov Research Institute Vaccines Sera (Russia). virus-containing fluid collected within three days from moment transfection infection intensity viral assessed by titration hemagglutination reaction. RNA concentration determined real-time reverse-transcription...
Objectives. Evaluation of changes in the viral activity influenza A/WSN/33 after complex knockdown combinations cellular genes FLT4, Nup98 and Nup205 human lung cell culture A549. Methods. The work was carried out using equipment Center for Collective Use I. Mechnikov Research Institute Vaccines Sera, Russia. authors performed transfection small interfering ribonucleic acid (siRNA) complexes that cause simultaneous disruption expression Nup98, Nup205. Within three days from moment infection,...
It is known that NMR spectroscopy can be effectively used to detect metabolic changes in the blood and urine caused by partial total body irradiation [1]. The purpose of our work was study composition metabolites erythrocytes after administration drug MYOTIVE rats irradiated with γ-radiation at a dose corresponding LD 50/30, evaluate radiomitigating properties drug.
About 1.2 billion cases of influenza infection with up to 5 million severe disease and 650,000 deaths from its complications are registered annually worldwide. High rates morbidity mortality attributed immunomodulatory properties some proteins produced by the viruses. Among these proteins, NS-1 is most studied. One main functions disrupt functioning interferon-mediated defense mechanisms body thus causing suppressed production different components humoral immunity, which leads an...
Aim . To compare the clinical efficacy and influence on interferon (IFN) production / sensing of drugs with immunemediated antiviral effects, which potentiate type 1 (T1) immune responses, in treatment acute respiratory infections (ARI) patients allergic rhinitis. Materials methods. 146 ARI remission seasonal rhinitis were divided into 4 cohorts. In addition to symptomatic therapy, received either 2,000 IU IFNγ each nasal passage 5 times a day; or rectal suppositories containing 106 IFN-α2b...
АннотацияЦель -оценка состояния кишечного микробиоценоза у ВИЧ-инфицированных детей в зависимости от стадии заболевания
Aim. To evaluate the efficacy and safety of OM-85 in treatment uncomplicated acute respiratory infections (ARI) adults. Materials methods. A double-blind, placebo-controlled, multicenter, randomized trial included 556 patients (18–60 years old) with mild moderate ARI negative results polymerase chain reaction analysis for SARS-CoV-2 RNA rapid test influenza B viruses. Patients were into two groups: first group (n=278), received (Broncho-munal®) one capsule 7 mg/day 10 days, while second...