Yu. V. Zakharova

ORCID: 0000-0002-3475-9125
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About
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Research Areas
  • Gut microbiota and health
  • Probiotics and Fermented Foods
  • Clostridium difficile and Clostridium perfringens research
  • Digestive system and related health
  • Cancer Research and Treatments
  • bioluminescence and chemiluminescence research
  • Gastrointestinal motility and disorders
  • Viral gastroenteritis research and epidemiology
  • HIV, TB, and STIs Epidemiology
  • Microscopic Colitis
  • Fungal Biology and Applications
  • Antifungal resistance and susceptibility
  • Dental Research and COVID-19
  • Mycobacterium research and diagnosis
  • Enzyme Production and Characterization
  • Advanced Chemical Sensor Technologies
  • Bacteriophages and microbial interactions
  • Pharmacological Effects of Natural Compounds
  • Pediatric Urology and Nephrology Studies
  • Diet and metabolism studies
  • Multiple and Secondary Primary Cancers
  • Genomics, phytochemicals, and oxidative stress
  • Liver Disease Diagnosis and Treatment
  • Medicinal plant effects and applications
  • Therapeutic Uses of Natural Elements

Kemerovo State Medical Academy
2004-2024

Ministry of Health of the Russian Federation
2015-2023

РезюмеВ лекции представлены достижения последних лет по систематике микроорганизмов.Приведен терминологический словарь, приведены правила и порядок присвоения

10.23946/2500-0764-2017-2-1-91-101 article RU Fundamental and Clinical Medicine 2017-01-01

10.26442/2413-8460_2018.1.95-99 article EN Pediatrics (Suppl Consilium Medicum) 2018-01-01

In vivo experiments have shown that the addition of caffeic acid to luminous mycelia higher fungi Neonothopanus nambi and Armillaria borealis stimulates a rapid significant (by an order magnitude or more) increase in intensity their light emission. It has been suggested observed effect fungal luminescence activation may be mediated by oxidation enzymes ligninolytic complex basidiomycetes (in particular, peroxidases) with emission visible quanta. Comparative showed hispidin (the precursor...

10.29039/rusjbpc.2023.0592 article EN cc-by Russian Journal of Biological Physics and Chemisrty 2024-05-16

Bacteria of the genus Campylobacter are a known common cause gastroenteritis. However, in recent years, there has been more and evidence scientific literature that these bacteria play an essential role development malignant tumors human digestive tract. The aim is to systemize data on pathogenicity/virulence factors spp. its carcinogenesis. review provides general description representatives question, indicating their current taxonomic position importance infectious pathology. A detailed...

10.14427/jipai.2024.2.37 article EN Immunopathology Allergology Infectology 2024-04-01

The article describes risk factors for the development of intestinal indigestion syndrome (IIS) in 109 patients with tuberculosis while they were receiving anti-tuberculosis chemotherapy (ATCT) and results assessment microbial population 30 before start. following made significant contribution to syndrome: HIV infection, number doses drugs taken, chronic gastrointestinal diseases. Even start chemotherapy, had disorders microflora, which characterized by a decrease quantity obligate bacteria,...

10.21292/2075-1230-2022-100-4-46-51 article EN cc-by Tuberculosis and lung diseases 2022-05-14

Today, there is an explosion of discoveries related to a growing understanding the role microbial communities, key species bacteria, products or metabolites derived from commensals, and in particular relationship between some these components painful conditions humans. Microbiota plays fundamental induction, training functioning host’s immune system. In turn, system has evolved significantly as means maintaining symbiotic relations with very diverse developing microbes. At optimal...

10.21518/2079-701x-2020-15-135-144 article EN cc-by-nc-nd Meditsinskiy sovet = Medical Council 2020-10-22

РезюмеЦель.Изучение механизмов устойчивости мембраны бифидобактерий разных видов к действию липаз Staphylococcus aureus.Материалы и методы.Исследовали количественный качественный состав жирных кислот мембран до после воздействия на них липолитических ферментов S.aureus с помощью газовой хроматографии масс-спектрометрическим детектором (ГХ-МС).Результаты.У Bifidobacterium breve основную массу мембранных составляли олеиновая (С 18:1; 80,3 мкг), пальмитиновая 16:0; 53,9 линолевая 18:2; 29,4...

10.23946/2500-0764-2017-2-1-6-13 article RU Fundamental and Clinical Medicine 2017-01-01

In the last decade there has been a very active study of large microbial community in human gut. The concept appeared explaining development and persistence symptoms irritable bowel syndrome due to disturbances intestinal landscape. Manipulation microflora represents new strategy for treatment this polietiologic disease. modulation bacterial at which beneficial (Lactobacilli Bifidobacteria) bacteria are increased pathogenic (Clostridium, Escherichia coli, Salmonella, Shigella Pseudomonas)...

10.21518/2079-701x-2017-5-85-92 article EN cc-by-nc-nd Meditsinskiy sovet = Medical Council 2017-01-01

The article tells about the prevalence and etiopathogenesis of antibiotic-associated diarrhea main pathogens focusing on Clostridium difficile. methods treatment disease are described. is largely an overview research reports use probiotics for prevention diarrhea. In accordance with declared topic, author’s original study probiotic complex Linex® Forte presented.

10.21518/2079-701x-2017-5-94-98 article EN cc-by-nc-nd Meditsinskiy sovet = Medical Council 2017-01-01

In some countries of the world, prevalence obesity is increasing at rate an epidemic. A significant role in staying healthy, strengthening immunity and normalizing metabolism assigned to microbes. Among drugs that are used treat serious infectious diseases, antibiotics dominate as keep on saving precious human lives. The side effects antibiotic therapy intestinal microflora range from self-leveling fast-passing “functional” diarrhea life-threatening pseudomembranous colitis. Recently...

10.33149/vkp.2019.01.09 article EN Herald of Pancreatic Club 2019-02-19

Aim is to evaluate the biological properties of bifidobacteria in HIV-infected children with different degrees gut microflora disorders determine direction for correction bifidobacterium HIV infection.Materials and methods. 58 selected cultures from children, 45 comparison group. In studied adhesion index microorganisms (IAM), hydrophobicity (H), acid formation, antioxidant activity (AOA), delayed antagonism opportunistic microorganisms.Results. at I degree did not differ group (p0.05). At...

10.36233/0372-9311-2019-3-3-9 article EN cc-by Journal of microbiology epidemiology immunobiology 2019-08-21

The antimicrobial effect of extracts from callus the common skullcap with prospect using in recipe a functional curd product for therapeutic and preventive action is studied. It known that plants genus contain phenolic compounds cause action, most among them are flavonoids-baykalin, scutellarein, hydrolyzed to glucuronic acid aglycones-baykalein vogonin, etc. Study activity was carried out accordance requirements state Pharmacopoeia XI edition. Antimicrobial determined relation 15 test...

10.20914/2310-1202-2020-1-178-182 article EN Proceedings of the Voronezh State University of Engineering Technologies 2020-05-15

10.33978/2307-3586-2020-16-15-40-47 article EN Effective Pharmacotherapy 2020-05-29

АннотацияЦель -оценка состояния кишечного микробиоценоза у ВИЧ-инфицированных детей в зависимости от стадии заболевания

10.14427/jipai.2020.2.90 article RU Immunopathology Allergology Infectology 2020-04-01

Aim. To estimate in vitro the effect of DNA isolated from probiotic strain Bifidobacterium bifidum 791 on cell concentration and adhesive properties fecal isolates bifidobacteria opportunistic microorganisms different species.Materials methods. was 791. Biomass containing washed nutrient medium. The suspension bacteria buffer solution subjected to ultrasonic disintegration with a frequency 40 kHz three times for 30 minutes, followed by centrifugation. supernatants were combined purified...

10.36233/0372-9311-2020-97-5-5 article EN cc-by Journal of microbiology epidemiology immunobiology 2020-11-04

The aim: In vitro identification of targets for antagonism factors in klebsiellas and enterococci Candida albicans isolated from the intestinal microbiome HIV infected patients.Materials methods. tests were performed using 38 strains, 28 Klebsiella pneumoniae 30 Enterococcus faecalis strains 89 children. mean age patients was 24 ± 2 months; group consisted 49 (55%) boys 40 (45%) girls. Microorganisms biotope such selective media as HiChrome Agar, Selective Agar Base, Agar; study included...

10.36233/0372-9311-271 article EN cc-by Journal of microbiology epidemiology immunobiology 2022-09-26

Introduction. Hepatocellular carcinoma is oft en asymptomatic in its early stages and when the tumor small. Though this type of accompanied with metastasis to lungs, present paper describes a patient whose both pathologies were accidentally detected by chest X-ray. According his medical history, last abdominal ultrasound was carried out three years ago. The aim clinical case which demonstrates primary cancer pulmonary metastases diagnostic potential radiological methods. Materials During...

10.24060/2076-3093-2022-12-3-256-260 article EN cc-by Creative Surgery and Oncology 2022-10-25

Polymerase chain reaction (PCR)-based diagnostics is currently established as a gold standard for the detection of microorganisms. The features PCR include rapid amplification DNA and RNA well high sensitivity specificity. In contrast to diagnostic microbiology, does not require preliminary culture microorganisms their identification, reducing both time costs procedure. lecture discusses molecular basis behind modern technical solutions human infectious diseases including multiplex reverse...

10.23946/2500-0764-2021-6-1-77-85 article EN Fundamental and Clinical Medicine 2021-03-29

ФУНДАМЕНТАЛЬНАЯ И КЛИНИЧЕСКАЯ МЕДИЦИНА 4 ТОМ 1, № 1 СОДЕРЖАНИЕ ОРИГИНАЛЬНЫЕ СТАТЬИ Раскина Т.А., Малышенко О.С., Пирогова О.А., Фанасков В.Б., Летаева М.В.Влияние противовоспалительной терапии на минеральную плотность кости у больных анкилозирующим спондилитом: результаты проспективного наблюдения (Кемерово) Ильинских Н.Н., Е.Н.Мониторинг цитогенетических последствий весенне-летним клещевым энцефалитом (Томск) Шакирова Е.А., Артымук Н.В.Факторы риска неэффективности лечения и рецидивирующего...

10.23946/2500-0764-2016-1-1-46-50 article RU Fundamental and Clinical Medicine 2016-01-01
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