A5091982544- Virus-based gene therapy research
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Viral Infections and Immunology Research
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
Sechenov University
2023
Introduction. Influenza is an acute respiratory viral infectious disease caused by the influenza viruses. Current preventive and therapeutic approaches are of great anti-epidemic importance, but there a number problems, such as rapid emergence resistant strains, lack cross-immunity effectiveness vaccines. One to development anti-influenza agents use RNA interference small interfering RNAs complementary mRNA target cellular genes. Aim ‒ evaluate prophylactic effect siRNAs directed genes NXF1,...
Introduction. Influenza is one of the most pressing global health problems. Despite wide range available anti-influenza drugs, viral drug resistance an increasing concern and requires search for new approaches to overcome it. A promising solution development drugs with action that based on inhibition activity cellular genes through RNA interference.
 Aim. Evaluation in vivo preventive potential miRNAs directed FLT4, Nup98 Nup205 against influenza infection.
 Materials methods. The...