A5032516263- Salmonella and Campylobacter epidemiology
- Brucella: diagnosis, epidemiology, treatment
- Exercise and Physiological Responses
- Parasitic Infections and Diagnostics
- Dermatology and Skin Diseases
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Asthma and respiratory diseases
- Phytochemical and Pharmacological Studies
- Muscle metabolism and nutrition
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Infant Nutrition and Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Burkholderia infections and melioidosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular and exercise physiology
- Food Allergy and Anaphylaxis Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Digestive system and related health
- Ovarian cancer diagnosis and treatment
- Genetic factors in colorectal cancer
- Viral Infections and Immunology Research
Sechenov University
2019-2024
St.Petersburg V.M.Bekhterev Psychoneurological Research Institute
2023
In ice hockey, the major physical workload comes from acceleration in all planes of motion and transitions between skating trajectories. Hockey players' anthropometric characteristics correlate with performance. team sports, use ergogenic drugs for recovery is relevant to avoid athletes' overtraining. It very important protect health allow them maintain high-performance levels. Cytoflavin an drug whose action based on combined effects its active ingredients (succinic acid, inosine,...
Introduction. Influenza is one of the most pressing global health problems. Despite wide range available anti-influenza drugs, viral drug resistance an increasing concern and requires search for new approaches to overcome it. A promising solution development drugs with action that based on inhibition activity cellular genes through RNA interference.
 Aim. Evaluation in vivo preventive potential miRNAs directed FLT4, Nup98 Nup205 against influenza infection.
 Materials methods. The...
Introduction. Today, prevalence of neurodegenerative diseases increases. In recent years, more studies have revealed a new knowledge about the role microglia in development these diseases. Animal experiments showed that peripheral inflammation causes activation brain. All this points to essential cells neurodegeneration. Under influence various factors, can change phenotype and participate both repair damage brain cells. Chronic herpesvirus infection caused by HSV-1 is another known factor...
Algorithm of intracellular bacterial parasitism does not depend on if bacterium is obligate or facultative parasite. Depending replicative niche’s localization parasites are divided onto cellular and vacuolated. Rickettsia spp., Shigella Chlamydia spp. Listeria monocytogenes use cell’s machinery actin polymerization during process their parasitism. These bacteria possess some effector’s proteins which contain domains identical to effector from the host cell. T3SS autotransporter protein IscA...
There are the high incidences of gallbladder cancer in endemic countries for S. Typhi infection. In this regions, majority chronic carriers suffer from calculous cholecystitis, that turn have been indicated as predisposing factor development cancer. Stones a represent sort platform formation bacterial biofilm. It was shown human bile activates synthesis third type secretory system (T3SS) responsible invasion into cells may result intracellular typhoid genotoxin with possible carcinogenic...
Mode of persistence in host cell nontyphoid serotypes (NTS) Salmonella enterica depends on the type cell. In epithelial cells NTS possess bephase life cycle. They ability to evade from salmonella containing vacuole into cytosole, where they begin cause hyperreplication. intestine large number replicated are extruded lumen intestine. Cytosole macrophages is non permissive for replication. Nonreplicating population persisters which tolerant antibiotic formed immediately after uptake by It...
Purpose: To develop a method for testing the MSI based on targeted NGS. Methods: Based results of previous studies, 81 microsatellite loci with high variability in MSI-H tumors were selected, and calculating score was developed. Using score, we defined status endometral (162), colon (153), stomach (190) cancers. Accuracy scores evaluated by comparison MMR immunohistochemistry 137 endometrium (63 dMMR 74 pMMR), 76 (29 47 (8 73 pMMR) Results: Classification MSS performed AUC (0.99),...
Object of study. The evaluation the interaction between breast milk opportunistic microorganisms abundance and whey antimicrobial activity at different periods lactation.
 Materials methods. 100 samples from healthy breastfeeding mothers were inoculated on solid selective media, then pure cultures identified by MALDI-TOF mass spectrometry. against a model culture Candida albicans was evaluated spectrophotometry.
 Results. 270 isolates represented 36 species 13 genera bacteria...
Bacterial vacuolated intracellular parasites, such as Salmonella spp. and Brucella spp., possess the ability to cause persistent, long-life chronic infection during which microbe continues replicate inside host organism in spite of development an immune response. Such bacteria develop a strategy evade response, plays key role infection. The implementation this is aimed at inhibiting action factors innate immunity. In brucella, process mediated by noncanonical structure lipopolysaccharide...
The overview presents data on the development of typhoid fever persistence infection associated with expression genes specific for S. Typhi pathogenicity island 7 (OSP7). Development is linked Salmonella (SPI7), which Typhi. Expression gene tviA from SPI7 promotes to escape recognition by immune system. Other 4 are synthesis and secretion genotoxin, inducing demage cells DNA, putative cause infection. Key words: Typhi, SPI7, tviA, chronic
Introduction . Pneumococcal diseases remain relevant for the whole world. On one hand, this is due to high prevalence of pneumococcus and other growth antibiotic-resistant strains constant change clinically significant serotypes pathogen. The aim research was study protective activity a mixture pneumococcal antigens. Material methods we used preparations capsular polysaccharide (CPS) obtained from Streptococcus pneumoniae serotype 3; protein-containing fraction (PCF) an aqueous extract cells...