A5061488168- Pediatric health and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- interferon and immune responses
- Antimicrobial Peptides and Activities
- Viral gastroenteritis research and epidemiology
- Oral microbiology and periodontitis research
- Animal Virus Infections Studies
- Long-Term Effects of COVID-19
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Neonatal Respiratory Health Research
- Virus-based gene therapy research
- IL-33, ST2, and ILC Pathways
- Oral Health Pathology and Treatment
- Glaucoma and retinal disorders
- Chemokine receptors and signaling
- Human Health and Disease
- Cervical Cancer and HPV Research
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences
2016-2025
Sechenov University
2017-2025
Pirogov Russian National Research Medical University
2015-2023
Laboratory of Molecular Genetics
2022
Scientific Center of Children's Health
2022
Lomonosov Moscow State University
2022
Russian Academy of Sciences
2021
Russian Medical Academy of Continuous Professional Education
2019
The aim of this study was to examine the in vitro antioxidant and antiviral activities echinochrome A echinochrome-based composition against tick-borne encephalitis virus (TBEV) herpes simplex type 1 (HSV-1). composition, which is a mixture A, ascorbic acid, α-tocopherol (5:5:1), showed higher effects than A. We suppose that its can both directly affect particles indirectly enhance defense mechanisms hosting cell. obtained results allow considering antioxidants on basis as promising agents...
We aimed to assess the effect of oral probiotics containing Streptococcus salivarius K12 strain on salivary level secretory immunoglobulin A, salivation rate, and biofilm. Thirty-one consenting patients meeting inclusion criteria were recruited in this double-blind, placebo-controlled, two-arm, parallel-group study randomly divided into probiotic (n = 15) placebo 16) groups. Unstimulated concentration Turesky index, Papillary-Marginal-Attached index assessed after 4 weeks intervention 2...
Abstract Mucosal immunity plays a major role not only in the prevention but probably also outcomes of COVID-19. An enhanced production secretory immunoglobulin A (sIgA) might contribute to activation immune response mechanisms. To assess levels sIgA produced by epithelial cells nasal and pharyngeal mucosa those measured salivary gland secretions study course COVID-19 following combined scheme intranasal subcutaneous administration bacteria-based immunostimulant agent. This included 69...
BACKGROUND: Influenza infection is one of the most pressing global health problems. The problems formation viral resistance to existing drugs and immunosuppressive effect induced by influenza virus are currently acute. A promising solution seems be creation whose action based on inhibition activity cellular genes through RNA interference. AIM: Evaluate anti-influenza immunomodulatory small interfering RNAs directed in an vivo model. METHODS: study used strain A/California/7/09 (H1N1), BALB/c...
Aim: to study the correlation of immune parameters in breast cancer patients undergoing general anesthesia and evaluate 1-year overall recurrence-free survival after surgery depending on technique. Materials Methods . A post hoc analysis data from a double-blind, randomized, controlled clinical trial involving 98 with operable was performed. Patients were divided into two groups: 48 received inhalational (IA) 50 total intravenous (TIVA). Immune (CRP, IgA, IgM, IgG, C3, C4, MMP-9, neutrophil...
A great deal of evidence has accumulated suggesting an important role mucosal immunity not only in preventing COVID-19 but also the pathogenesis this infection. The aim study was to evaluate levels secretory immunoglobulin (sIgA) different compartments upper respiratory tract patients relation severity disease and treatment with a bacteria-based immunomodulating agent (Immunovac VP4). titers sIgA were determined by ELISA nasal epithelial swabs, pharyngeal salivary gland secretions at...
Introduction. Influenza is an acute respiratory viral infectious disease caused by the influenza viruses. Current preventive and therapeutic approaches are of great anti-epidemic importance, but there a number problems, such as rapid emergence resistant strains, lack cross-immunity effectiveness vaccines. One to development anti-influenza agents use RNA interference small interfering RNAs complementary mRNA target cellular genes. Aim ‒ evaluate prophylactic effect siRNAs directed genes NXF1,...
BACKGROUND: modern medicine strives to provide minimally invasive surgical intervention, thereby ensuring a more comfortable course of the postoperative period. For this purpose, it is proposed consider use laser technologies in removal retarded third molars. Thus, interest conduct comparative analysis effectiveness using an erbium with wavelength 2940 nm and cutting rotating tools during lower molars extraction. AIMS: To Er:YAG for impacted accordance data clinical immunological parameters....
Relevance. Hepatitis E virus (HEV) is a common cause of viral hepatitis not only in areas with low levels water supply and hygiene, but also industrialized countries. Rapid tests development for the infection seromarkers detection absence special equipment trained staff remains most important problem improving diagnosis E. Aim. To produce conjugates recombinant ORF2 antigen HEV genotype 3 gold nanoparticles (GNP) varied sizes to evaluate their applicability immunoassay antibodies HEV....
BACKGROUND:Phototherapy is one of the most effective methods in treatment psoriasis, but mechanism its action on innate immunity has not been studied.AIMS: Investigation local expression profile factors patients with psoriasis duringphototherapy.MATERIALS AND METHODS:The study included 31 diagnosed inpatient vulgaris. The materialfor was obtained from areas affected and unaffected skin. Patients vulgar received a course UVB-311 nm phototherapy lasting 5 to 7 weeks total dose 35.2 44.6 J/cm2....
The SARS-CoV-2 virus is a pathogen causing the coronavirus infection that culminated in worldwide pandemic 2020. It belongs to β-coronaviruses and has high genetic similarity SARS-CoV responsible for an outbreak of severe acute respiratory syndrome 2002–2003. analysis molecular interactions shows higher virulence due lower binding free energy interaction with angiotensin-converting enzyme 2 (ACE2), which used by enter host cell. At time global pandemic, thorough study ACE2 as key component...
The mechanisms of the formation immunological competence against tuberculosis (TB), and especially those associated with HIV co-infection, remain poorly understood. However, there is an urgent need for risk recurrence predictive biomarkers, as well predictors successful treatment outcomes. goal study was to identify possible markers TB in individuals HIV/TB co-infection.
Breast cancer (BC) mortality primarily stems from metastases rather than the primary tumor itself. Perioperative stress, encompassing both surgical and anesthetic factors, profoundly impacts immune system, leading to alterations in neuroendocrine pathways functions, potentially facilitating progression metastasis. Understanding immunomodulatory effects of different anesthesia techniques is crucial for optimizing perioperative care patients with BC. The neutrophil-to-lymphocyte ratio (NLR)...
Tuberculosis (TB) and HIV have profound effects on the immune system, which can lead to activation of viral replication negatively regulate T cells. Dysregulation in production cytokines necessary fight M. tuberculosis may ultimately affect results treatment be important pathogenesis infection TB. This work presents a study expression pro- anti-inflammatory (IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-1RA) drug-naïve patients with dual HIV/TB at late stages HIV-infection, newly diagnosed TB,...
Background Plaque psoriasis is a chronic autoimmune disorder characterized by the development of red scaly plaques. To date lesional skin transcriptome has been extensively studied, whereas only few proteomic studies psoriatic are available. Aim The aim this study was to compare protein expression patterns and normally looking patients with healthy volunteers, reveal differentially expressed proteins identify changes in cell metabolism caused disease. Methods Skin samples donated (n = 5)...
A better understanding of the pathogenesis preterm birth (PTB) will allow us to lower PTB rate, reducing perinatal morbidity and mortality. This article presents hypothesis that premature placenta apoptosis could be a potential cause PTB. We evaluated gene expression involved in apoptosis: caspase-3, caspase-8, XIAP (X-linked inhibitor apoptosis) during pregnancy (n = 41), at onset labour 42), after 44) term 32) labour. used RNA extraction, reverse transcription, PCR. During caspase-3...
Oncolytic viruses, including live attenuated measles virus (MV) vaccine strains, have recently been shown as promising therapeutic agents against human malignancies. In this study, the oncolytic potential of strain Leningrad-16 (L-16) MV was evaluated in a panel metastatic melanoma cell lines. The L-16 to replicate within cells mediating direct killing tumor cells, although all lines varied regard their ability respond infection, revealed by different pattern Interferon Stimulated Gene...
HIV-1 infection is characterized by aberrant immune activation, and with M. tuberculosis an unbalanced production of proinflammatory cytokines. The expression these cytokines in HIV-1/TB coinfection still understudied. Here, we aimed to compare the drug-naive patients coinfected (HIV/TB) compared respective monoinfections. Plasma samples HIV/TB (n = 36), monoinfection TB 35) healthy donors 36) were examined for levels eight Their significantly increased all patient groups donors. At same...