A5079156904- Bioactive Compounds and Antitumor Agents
- Cytomegalovirus and herpesvirus research
- Beetle Biology and Toxicology Studies
- biodegradable polymer synthesis and properties
- Virus-based gene therapy research
- Seaweed-derived Bioactive Compounds
- Advanced Drug Delivery Systems
- Echinoderm biology and ecology
- Systemic Lupus Erythematosus Research
- Viral Infectious Diseases and Gene Expression in Insects
- Biochemical Acid Research Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Fungal Biology and Applications
- Metabolism and Genetic Disorders
- Phytochemistry and Bioactive Compounds
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Herpesvirus Infections and Treatments
- Neurological Disorders and Treatments
- Allelopathy and phytotoxic interactions
- Free Radicals and Antioxidants
- Phytochemical compounds biological activities
- Cancer Treatment and Pharmacology
- Macrophage Migration Inhibitory Factor
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences
2018-2021
Tbilisi State Medical University
2020-2021
The enzymatic depolymerization of fucoidans from brown algae allowed the production their standardized derivatives with different biological activities. This work aimed to compare antiviral activities native (FeF) and modified enzyme (FeHMP) F. evanescens. cytotoxicity FeF FeHMP against herpes viruses (HSV-1, HSV-2), enterovirus (ECHO-1), human immunodeficiency virus (HIV-1) in Vero MT-4 cell lines were examined by methylthiazolyltetrazolium bromide (MTT) cytopathic effect (CPE) reduction...
The aim of this study was to examine the in vitro antioxidant and antiviral activities echinochrome A echinochrome-based composition against tick-borne encephalitis virus (TBEV) herpes simplex type 1 (HSV-1). composition, which is a mixture A, ascorbic acid, α-tocopherol (5:5:1), showed higher effects than A. We suppose that its can both directly affect particles indirectly enhance defense mechanisms hosting cell. obtained results allow considering antioxidants on basis as promising agents...
The aim of the work was to study activity echinochrome A, a naphthoquinoid pigment from sea urchins, and its antioxidant composition against herpes simplex virus type 2 (HSV-2) in vitro vivo.Materials methods. Strain HSV-2 (G ATCC VR-734) grown Vero cells. cytotoxic anti-HSV-2 compounds assessed by cell viability cytopathic effect inhibition using MTT test. efficacy mice model vaginitis caused determined average lifetime, body weight viral load changes.Results discussion. (echinochrome...
The aim of this study was to examine in vitro the antioxidant and antiviral activity echinochrome A echinochrome-based composition against tick-borne encephalitis virus (TBEV) herpes simplex type 1 (HSV-1). Materials methods. TBEV (Dal’negorsk strain, Far Eastern subtype) grown PK cells, HSV-1 (VR3 strain) Vero cells. compounds determined using linetol peroxide oxidation model. cytotoxicity were assessed by cell viability (PK- cells) cytopathic effect inhibition viruses (TBEV HSV-1) MTT...