A5021542525- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Human Health and Disease
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Healthcare Systems and Public Health
- Reproductive tract infections research
- Immune Cell Function and Interaction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Response and Inflammation
- Infant Nutrition and Health
- HIV, TB, and STIs Epidemiology
- Immune responses and vaccinations
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Respiratory and Cough-Related Research
- Pregnancy and preeclampsia studies
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Preterm Birth and Chorioamnionitis
Russian Medical Academy of Continuous Professional Education
2019-2025
Samara State Medical University
2023-2024
Ministry of Health of the Russian Federation
2023-2024
Novokuznetsk State Institute of Advanced Medical Education
2015-2024
Institute for Postgraduate Medical Education
2023
Kyiv City Clinical Oncology Center
2011
Abstract Mucosal immunity plays a major role not only in the prevention but probably also outcomes of COVID-19. An enhanced production secretory immunoglobulin A (sIgA) might contribute to activation immune response mechanisms. To assess levels sIgA produced by epithelial cells nasal and pharyngeal mucosa those measured salivary gland secretions study course COVID-19 following combined scheme intranasal subcutaneous administration bacteria-based immunostimulant agent. This included 69...
Background Influenza vaccine is a tool for preventing infection and reducing exacerbations in patients with asthma chronic obstructive pulmonary disease (COPD). However, the associations between clinical outcomes changes levels of inflammation markers have not been fully delineated. The purpose this study was to investigate course or one year after vaccination against influenza. Methods prospective included 34 asthma, 20 COPD vaccinated influenza, both groups being under basic maintenance...
A great deal of evidence has accumulated suggesting an important role mucosal immunity not only in preventing COVID-19 but also the pathogenesis this infection. The aim study was to evaluate levels secretory immunoglobulin (sIgA) different compartments upper respiratory tract patients relation severity disease and treatment with a bacteria-based immunomodulating agent (Immunovac VP4). titers sIgA were determined by ELISA nasal epithelial swabs, pharyngeal salivary gland secretions at...
Although extensive research has been conducted on the role of local immunity in patients with SARS-CoV-2, little is known about production and concentrations secretory IgA (SIgA) different mucosal compartments. This article aims to assess secretion SIgA nasal pharyngeal compartments saliva COVID-19 investigate possibility efficiency correction their using combined intranasal oral administration a pharmaceutical containing antigens opportunistic microorganisms.
Aim: To study the manifestations of COVID-19 epidemic and clinical epidemiological characteristics adult patients with a new coronavirus infection during dominance Delta SARS-COV-2 in Russian Federation. Materials Methods : Study included aged ≥18 years laboratory-confirmed diagnosis COVID-19, detected period from 09/01/2021 to 11/30/2021 (n= 2 619 298) 85 regions. Results There were periods rise decline incidence mortality spread SARS-CoV-2 Russia: June-September OctoberDecember 2021 (Wald...
Background. Mortality and COVID-19 related factors are thoroughly analyzed. Given the large number of hospitalized patients, potential short- long-term complications, further research is needed on possible consequences hospitalization, especially in higher-risk after prolonged hospitalization intensive care admission. Aim. To study clinical course outcomes severe elderly patients with asthma at hospital early post-hospital stages. Materials methods. The included 131 (WHO, 2020) 60 years old,...
Background: Recent addition to vaccines of adjuvants has been actively used enhance the immunogenicity. However, use for development quadrivalent inactivated influenza (QIV) is currently limited. The aim this study was examine immunogenicity adjuvanted QIV in healthy people and patients with primary immune deficiency-common variable deficiency (CVID). Methods: In total before flu season 2018-2019 were involved 32 volunteers aged 18-52 years 6 a confirmed diagnosis CVID 18-45 years. To...
Vaccination is the most effective method of influenza prophylaxis resulting in reduced frequency and severity complications. Currently, for prevention influenza, inactivated split subunit vaccines as safest promoting formation protective level strain-specific virus neutralizing antibodies are used. It known that not all enough select human groups. While nowadays public health low, there a need to improve effectiveness should activate chains immune system. In order enhance intensity antibody...
This study investigates the efficiency of two different types immunomodulators for treatment non-severe community-acquired pneumonia (CAP) and assesses their long-term effects.The included 55 patients with CAP. Group 1 (control) received only standard CAP therapy; other groups simultaneously therapy: bacterial lysate group 2 azoximer bromide (AzB) 3. TNF IL-6 concentrations were determined on day hospitalization as well days 13 60 follow-up. For years, we monitored incidence low respiratory...
The objective : to study the effect of immunomodulators on markers acute inflammation phase in patients with mild community-acquired pneumonia (CAP). Subjects and methods . Patients (n = 64) CAP (39.62 ± 9.82 years, CRB – 650.15 0.04 scores) were enrolled study. divided into 2 groups: Group 1 (control) received only standard therapy; other two groups, prescribed simultaneously therapy: bacterial lysate (BL), 3 azoximer bromide (AB). In patients, blood levels IL-6, TNF-α, C-reactive protein...
Individuals without a protective antibody level are susceptible to measles infection. There differences in the persistence of antibodies after vaccination and infection, while impact gender on this process has not been sufficiently studied. Measles Ig G were measured 1742 employees large hospital facility-403 men 1339 women aged from 25 67 years; 15% participants had levels less than threshold ≥0.18 IU/mL. Significant found age group 40-49, where IgG among was higher (1.51 IU/mL (0.41; 3.38)...
Influenza prophylaxis with the use of quadrivalent vaccines (QIV) is increasingly being introduced into healthcare practice.In total, 32 healthy adults and 6 patients common variable immunodeficiency (CVID) received adjuvant QIV during 2018-2019 influenza season. Depending on initial antibody titers, volunteers were divided seronegative (≤1:20) seropositive (≥1:40). To evaluate immunogenicity hemagglutination inhibition assay was used.All participants completed study without developing...
Bronchial asthma occurs in 0.9 – 17% of patients hospitalized with COVID-19. However, it is not clear whether a risk factor for the development and severity Studies have shown that appear to be more susceptible COVID-19 infection, but severe disease progression related medication use, including biologics, rather older age comorbidities. Aim. To evaluate clinical course SARS-CoV-2 infection elderly asthma, examine effect comorbidities on COVID-19related outcomes, determine predictors...
It has been proven that post-vaccination immunity to measles virus after two doses of vaccine is not able persistently protect against infection throughout life. The goal this research was determine the immune layer among women in labor and maternity ward personnel same medical institution. levels IgG antibodies umbilical cord blood 594 88 workers were studied by ELISA. revealed 22.7% serum samples from parturient 21.4% seronegative (<0.18 IU/ml). Levels low values (<1.0 IU/ml)...
Early studies on vaccination of children with oncological diseases were only dedicated to the assessment safety and immunogenicity drug. Mechanisms post-vaccination immune response not investigated. This study involved 41 patients aged 7-15 years who treated for solid tumors two or more ago. Of these, 26 vaccinated against diphtheria tetanus ADS-m toxoid. Fifteen (i.e., controls) vaccinated. The tolerability clinical characteristics underlying disease remission ware assessed. Lymphocyte...
Relevance. During and after the COVID-19 pandemic, viruses have become a more common cause of pulmonary infections in adults; therefore, distinction between viral lung injury community-acquired bacterial pneumonia is increasing importance. Aim. Development model for differentiating injury, including COVID-19. Materials methods. This retrospective case–control study included 300 adult patients with 100 pneumonia. Clinical, laboratory, instrumental data were analyzed, significant factors...
A decrease of nonspecific body resistance, an imbalance local and systemic immunity a free-radical oxidation abnormality substantially contribute to the pathogenesis community-acquired pneumonia (CAP). Purpose: To study efficiency including immunomodulators into comprehensive treatment nonsevere assess long-term effects conducted. Patients (n = 55) with non-severe CAP (41 (31-48) years old, CRB-65 score 0.15 (0-1)) are included in study. Group 1 (control) received only standard therapy;...
Background. Given the high prevalence of Bordetella pertussis, patients with respiratory disorders are at risk getting infected this pathogen and developing pertussis. Therefore, they should be considered a target group for vaccination against infection. Aims — objective study was to assess vaccine-induced immunity pertussis in lung transplant candidates. Methods. Twenty-four severe bronchopulmonary diseases, aged 18 60, were vaccinated Diphtheria Tetanus Toxoids Acellular Pertussis Vaccine....
Background: The problem of identifying vaccine-specific T-cell responses is still a matter debate. Currently, there are no universal, clearly defined, agreed upon criteria for assessing the effectiveness vaccinations and their immunogenicity cellular component immunity, even healthy people. But patients with inborn errors immunity (IEI), especially those antibody deficiencies, evaluating holds significant importance. Aim: To examine effect one two doses inactivated adjuvanted subunit...
Objective. To study the etiology of community-acquired pneumonia (CAP) in adult hospitalized patients after COVID-19 pandemic. Materials and Methods. The prospective multicenter included 18 years older with confirmed diagnosis CAP admitted to 6 hospitals different regions Russia from July November 2023. Etiology was by respiratory samples (sputum, tracheal aspirate) culture, blood culture (severe cases), urinary antigen tests (Legionella pneumophila serogroup 1, Streptococcus pneumoniae)....