A5013599452- Virology and Viral Diseases
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Immune responses and vaccinations
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Rheumatoid Arthritis Research and Therapies
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Monoclonal and Polyclonal Antibodies Research
- Asthma and respiratory diseases
- COVID-19 Pandemic Impacts
- Human Health and Disease
- HIV, TB, and STIs Epidemiology
- COVID-19 and Mental Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Genital Health and Disease
- Blood Coagulation and Thrombosis Mechanisms
- Vitamin D Research Studies
- COVID-19 Impact on Reproduction
- Neonatal Respiratory Health Research
- Enterobacteriaceae and Cronobacter Research
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences
2015-2025
Background Influenza vaccine is a tool for preventing infection and reducing exacerbations in patients with asthma chronic obstructive pulmonary disease (COPD). However, the associations between clinical outcomes changes levels of inflammation markers have not been fully delineated. The purpose this study was to investigate course or one year after vaccination against influenza. Methods prospective included 34 asthma, 20 COPD vaccinated influenza, both groups being under basic maintenance...
Relevance. Pneumococci are among the most common causative agents of severe bacterial infections in humans. The prevalence invasive pneumococcal people with autoimmune inflammatory rheumatic diseases is 3–4 times higher than general population. Aim. To evaluate effectiveness vaccination 13-valent conjugate vaccine (PCV 13) patients rheumatoid arthritis (RA). Materials and Methods. data scientific publications PubMed, Web Science, elibrary, National Inpatient Database USA, Moscow Unified...
Vaccination is the most effective method of influenza prophylaxis resulting in reduced frequency and severity complications. Currently, for prevention influenza, inactivated split subunit vaccines as safest promoting formation protective level strain-specific virus neutralizing antibodies are used. It known that not all enough select human groups. While nowadays public health low, there a need to improve effectiveness should activate chains immune system. In order enhance intensity antibody...
Within a framework of the state measles elimination program, in April, 2018 level herd immunity was assessed 1899 Moscow hospital medical workers aged from 19 to 69 years and older. All subjects enrolled study were vaccinated against or recovered after infection. Serum samples collected examined by ELISA for IgG antibodies with Vector-Best IgG-measle test system (Russia). It found that 278 (14.6%) 1621 (85.4%) seronegative ( 0.18 IU/mL) seropositive IU/ml), respectively. Age-related group...
Характеристика нового коронавируса COVID-19В декабре 2019 г. в Ухане (Китайская Народная Республика) возникла вспышка случаев атипичной пневмонии, вызванная вновь появившемся β-коронавирусом.Первоначально 12 января 2020 г
Immunological aspects of features post-vaccine immune response to measles virus are presented and causal relationships detected, that lead the disappearance protective antibodies against virus, as one arguments for improvement vaccination tactics with aim increase population enhancement epidemiologic situation regarding in general. At contemporary stage during mass vaccinations a portion seronegatives among women reproductive age newborns (up 20.1%) an additional this parameter by 8 - 13%...
Introduction. Mass vaccination and re-vaccination against measles as of children, well additionally in adults, contributed to the significant decrease morbidity rate. At same time, outbreaks recent years, both World Russia, became more frequent, especially adult population. Aim: To determine content transplacental IgG-antibodies virus umbilical cord blood, with taking into account age mother. Materials methods. There was studied blood offsprings 672 parturient women aged 16-43 years old,...
Aim. Determination of intensity immunity against measles in patients on waiting-list for lung transplantation. Materials and methods. IgG levels virus were studied blood sera 80 adult (mean age 35.8± 11.4 years) transplantation, without history this disease. was carried out by ELISA using a standard kit from «Vektor-Best» (VectoMeasles-IgG). Results. Protective level (above 0.18 I U/ml) registered 83.3% examined patients. Mean anti-measles antibodies within protective values - 1.53 IU/ml...
It has been proven that post-vaccination immunity to measles virus after two doses of vaccine is not able persistently protect against infection throughout life. The goal this research was determine the immune layer among women in labor and maternity ward personnel same medical institution. levels IgG antibodies umbilical cord blood 594 88 workers were studied by ELISA. revealed 22.7% serum samples from parturient 21.4% seronegative (<0.18 IU/ml). Levels low values (<1.0 IU/ml)...
Vaccination against flu in the second and third trimesters of pregnancy with use Agrippal S1 is effective meets CPMP criteria.In our study, one month after vaccination, there was progress production post-vaccination antibodies protective values pregnant women vaccinated trimester gestation.In neonates whose mothers had been last pregnancy, were also higher levels to A virus strains.Three months childbirth, no significant differences all strains compared groups.At same time, children born a...
Recent epidemiological events showed that pregnant women are the most vulnerable part of population if there is flu in country and they die much more often than rest people. That why influenza vaccination including one priorities public health service our state. Worldwide experience either adults or children by new adjuvant vaccine has caused research its efficiency among women. The aim study was to investigate level antibodies virus strain A/H1N1/v, A/H3N2 B vaccinated trivalent subunit...
The article presents the analysis of numerous scientific studies carried out in Russia with use pneumococcal polysaccharide vaccine immunocompetent and immunocompromised patients. New data are available to assess impact vaccines on clinical immunological aspects a particular pathology children, which allows reveal mechanisms associated effectiveness vaccination.
The presented review searched for articles in the databases PubMed, Web of Science, Scopus, Google Scholar, eLibrary (2002-2022) and assessed immunogenicity 23-valent polysaccharide pneumococcal vaccine (PPV23) adult patients with rheumatoid arthritis (RA), receiving various antirheumatic drugs. results this indicated sufficient PPV23 RA monotherapy biological drugs (bDMARDs) (TNFα inhibitors, IL6 receptor T-lymphocyte costimulation blockers), targeted synthetic disease-modifying (tsDMARDs),...
Abstract Rheumatoid arthritis (RA) is an joint autoimmune inflammatory disease characterized by systemic destructive and progressive synovitis caused chemokines, reactive oxygen species, proinflammatory cytokines produced neutrophils macrophages in the synovial membrane. Objective: to study indices of leukocyte phagocytic activity factors oxygen-dependent bactericidal patients with rheumatoid receiving methotrexate (MT) tofacitinib (TOFA), vaccinated a conjugate pneumococcal vaccine (PCV13)....
Background: Influenza vaccine is a tool for preventing infection and reducing exacerbations in patients with asthma chronic obstructive pulmonary disease (COPD). Purpose of this study to investigate dynamics CRP serum cytokines (IL-2, IL-6, IL-10, IL-17) COPD, as well perform correlation analysis the clinical parameters manifestation. Methods: The included 34 asthma, 20 COPD vaccinated against influenza during period remission from 2 4 weeks, both groups being under basic maintenance...
The review provides information on the importance of immunoprophylaxis epidemic controlled infections in pregnant women. It is shown that most severe complications pregnancy occur when women are infected with respiratory pathogens, especially influenza virus late stages gestation. Newborns also have a high risk fatal disorders and an infant mortality rate cases maternal influenza. Modern inactivated vaccines used many countries since second period gestation safety immunological efficacy for...
РезюмеЦель: изучение уровня антител к штаммам вируса гриппа, входящим в состав субъединичной трехвалентной вакцины, с учетом триместра иммунизации беременных
A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It shown that vs. without bacterial vaginosis were featured low level 53.8–60.5% cases. Administration combination antibacterial therapy conferred anti-inflammatory effect resulting normalized IL-8 corresponding one healthy subjects. Use altered status augmented antimicrobial activity confirmed by reduced rate ARI episodes.
Introduction. The study of the intensity humoral immunity to measles virus (Paramyxoviridae: Morbillivirus) (MV) remains relevant due ongoing registration cluster cases (including nosocomial cases).The aim was analyze correlation between and incidence in different age groups Moscow residents.Material methods. A simple analytic carried out under framework prevention improvement program conducted subjects Russian Federation. included analysis reasons for increase proportion seronegative...
Background. Vaccination against pneumococcal infection is one of the priorities in improving quality treatment and prevention measures adults with various pathologies. The effectiveness vaccination directly related to individuals ability form an adequate specific immunity. Aims aim study was assess level post-vaccination antibodies capsular polysaccharides S. pneumoniae adult patients bronchial asthma (BA) or chronic obstructive pulmonary disease (COPD) after administration 13-valent...