A5045535581- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Bacterial Infections and Vaccines
- Nosocomial Infections in ICU
- Yersinia bacterium, plague, ectoparasites research
- Antifungal resistance and susceptibility
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric Urology and Nephrology Studies
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood transfusion and management
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Bacterial biofilms and quorum sensing
- Bone Tissue Engineering Materials
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Security, Politics, and Digital Transformation
- Diamond and Carbon-based Materials Research
Burdenko Neurosurgery Institute
2021-2024
Smolensk State Medical University
2012-2024
British Society for Antimicrobial Chemotherapy
2012
Surveillance of antimicrobial resistance (AMR) is crucial for identifying trends in and developing strategies prevention treatment infections. Globally, AMR surveillance systems differ terms organizational principles, comprehensiveness, accessibility, usability data presentation. Until recently, the on Russia were scarcely available, especially to international community, despite fact that large prospective multicenter was conducted accumulated over 20 years. We describe source data,...
Objective. To assess rates of antimicrobial resistance and production the clinically important acquired mechanisms (extended spectrum beta-lactamases [ESBL] carbapenemases) in nosocomial strains Enterobacterales, to determine genotypes prevalence "international high-risk clones" among carbapenemase-producing Klebsiella pneumoniae isolated various Russian regions within "MARATHON 2015–2016" study. Materials Methods. A total 2786 non-duplicate isolates including 1316 K. 837 Escherichia coli 49...
Objective. To study in vitro activity of antimicrobials against clinical isolates from patients with communityacquired urinary tract infections (UTIs) different regions Russia 2017–2018. Materials and Methods. A total 1052 Enterobacterales collected the Russian Federation as part a multicenter, prospective, epidemiological antimicrobial resistance uropathogens causing community-acquired UTI subsets ("DARMIS-2018") were included analysis. Uropathogens isolated children adults both sexes all...
There is a problem of bacterial contamination autologous blood despite long-term experience intraoperative salvage and reinfusion.
Objective. To study the prevalence and mechanisms of antibiotic resistance, including carbapenemase production, in clinical isolates Klebsiella pneumoniae Escherichia coli isolated different regions Russia as part sentinel multicenter surveillance 2020–2021, to explore population structure K. impact “high-risk clones” on resistance. Materials Methods. Consecutive, non-duplicate (n = 2503) E. 2055) from various specimens (blood, cerebrospinal fluid, respiratory samples, urine, wound...
A high level of resistance to carbapenems in Acinetobacter baumannii strains severely limits therapeutic possibilities. Colistin is the last resort drug against such strains, although cases this have become more frequent. This article presents epidemiological features and genetic diversity colistin nonsusceptible A. collected as part a national multicenter study antibiotic pathogens nosocomial infections (MARATHON), which was conducted 2013-2014 Russia. total 527 isolates were collected, 10...
Objective. Objectives. To assess the rates of antibiotic resistance and production acquired carbapenemases in nosocomial strains Acinetobacter spp., to determine genotypes prevalence "international high-risk clones" among baumannii isolated various regions Russia within "MARATHON 2015–2016" study. Materials Methods. A total 1005 non-duplicate isolates including 975 A. baumannii, collected 44 hospitals from 25 cities 2015– 2016 were studied.
Objective. Objectives. To assess the rates of antibiotic resistance, production acquired carbapenemases, genotypes and prevalence «international high-risk clones» among nosocomial strains Pseudomonas aeruginosa isolated in various regions Russia within «MARATHON 2015–2016» study. Materials Methods. A total 1006 non-duplicate isolates P. collected 44 hospitals from 25 cities 2015–2016 were studied. Species identification was performed by means MALDI-TOF mass-spectrometry.
To study in vitro activity of antimicrobials against clinical isolates from patients with community-acquired urinary tract infections (UTIs) different regions Russia, Belarus and Kazakhstan 2017-2018.A total 1260 collectedin the Russian Federation, Kazakhstanas a part international multicenter prospective epidemiological dynamics antimicrobial resistance uropathogens causing subsets ("DARMIS-2018") were included analysis. 1124 strains represented Enterobacterales order. Uropathogenswere...
Objective. To evaluate antimicrobial resistance patterns of clinical Haemophilus influenzae isolates from different regions Russia during 2014–2017. Materials and Methods. We included in the study 185 H. 13 Russian cities. Susceptibility testing was performed by reference broth microdilution method (ISO 207761:2006). results were interpreted using EUCAST v. 10.0 breakpoints. Results. highly susceptible to all (96.8%-100%) β-lactams tested (amoxicillin/ clavulanate, cefixime, ceftaroline,...
Objective. To assess the prevalence and antimicrobial susceptibility of carbapenemase-producing Enterobacterales (CPE). Materials Methods. A total 5539 isolates recovered from hospitalized patients in 52 medical institutions 27 cities Russia 2014-2016 were tested. Antibiotic testing (AST) was performed using broth microdilution method according to ISO 20776-1:2006. Avibactam tested combinations with beta-lactams at fixed concentration 4 mg/l. AST results interpreted EUCAST v8.
Chronic heart failure (CHF) is one of the most common comorbidities in elderly patients with community-acquired pneumonia (CAP). The aim this study was to investigate etiology CAP concomitant CHF. Methods . This prospective observational involved adult hospitalized and confirmed by chest X-ray. Sputum samples or oropharyngeal swabs, blood urine were collected all eligible before starting therapy systemic antibiotics. cultured for «typical» bacterial pathogens, such as Streptococcus...
Objective. To evaluate antimicrobial resistance patterns of clinical Streptococcus pneumoniae isolates from different regions Russia during 2014–2017. Materials and Methods. We included in the study 519 S. 18 Russian cities. Susceptibility testing was performed by reference broth microdilution method (ISO 20776-1:2006). results were interpreted according to EUCAST v.9.0 breakpoints. Results. Using non-meningeal interpretation criteria, 65.1% tested susceptible (S) penicillin; addition 28.
Objective. To assess the in vitro activity of ceftazidime-avibactam against clinical Enterobacterales and Pseudomonas aeruginosa isolates various regions Russia based on results local susceptibility testing by disk diffusion method. Materials Methods. Overall, 160 laboratories located 61 Russian cities participated this surveillance during 2018-2020. All consecutive each participating laboratory were included study. Ceftazidime-avibactam was done disc-diffusion method accordance with current...
Objective. To estimate prevalence and antimicrobial susceptibility of circulated S. pneumoniae serotypes in adult population different regions the Russian Federation. Materials Methods. A total 500 isolates obtained from patients with invasive pneumococcal disease (IPD), community-acquired pneumonia (CAP), sinusitis/acute otitis media (AOM) healthy carriers 29 centers were included study 01 June 2019 to 15 January 2020. Re-identification, typing using real-time PCR 27 primer pairs testing...
Purpose of the study – to evaluate antibacterial activity and biological compatibility alloy coatings based on two-dimensionally ordered linear chain carbon (TDOLCC).Materials Methods. Coatings TDOLCC were synthesized using alloying additions like nitrogen (TDOLCC+N) silver (TDOLCC+Ag) surfaces titanium plates polystyrene by ion-stimulated condensation in a vacuum. The authors examined superficial bactericidal its resistance mechanical effects. Coated evaluated respect rate microbial...
Staphylococcus aureus - one of the most interesting for clinical studies microbial species with extensive strain diversity, primarily due to variability virulence factors and pathogenicity. The aim this study was approbation a method rapid differentiation S. on basis bacterial cell direct protein profiling approach by means MALDI TOF MS. Beta-lactamase alpha-hemolysin productions, cording blaZ hla genes, respectively, were selected as markers differentiation. Mathematical analysis mass...
Objective. To determine susceptibility of C. glabrata isolates to anidulafungin, caspofungin and micafungin using the SensititreTM YeastOneTM system. Materials Methods. were taken prospectively from clinical specimens or strains collections in participating sites. Susceptibility determination was performed (YO10 panel) according manufacturer’s guidance, results interpreted with M27-A3 CLSI guidelines. fluconazole also determined order assess possible correlations echinocandins minimal...
We report a Russian case of 61-year-old male patient with confirmed COVID-19 infection who developed nosocomial pneumonia complicated by lung abscess associated multi-drug-resistant isolates
Objective. To study the etiology of community-acquired pneumonia (CAP) in adult hospitalized patients after COVID-19 pandemic. Materials and Methods. The prospective multicenter included 18 years older with confirmed diagnosis CAP admitted to 6 hospitals different regions Russia from July November 2023. Etiology was by respiratory samples (sputum, tracheal aspirate) culture, blood culture (severe cases), urinary antigen tests (Legionella pneumophila serogroup 1, Streptococcus pneumoniae)....
Autologous blood obtained during hardware reinfusion can be bacterially contaminated with skin microflora in most cases (up to 90%) regardless of the area surgical intervention. Increased volume washing solution for red cell management, white filtration and X-ray irradiation do not always provide complete decontamination.