A5001297212- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
- Bacterial Infections and Vaccines
- Helicobacter pylori-related gastroenterology studies
- Respiratory viral infections research
- Urinary Tract Infections Management
- Veterinary medicine and infectious diseases
- Antibiotic Use and Resistance
- Pediatric health and respiratory diseases
- Yersinia bacterium, plague, ectoparasites research
- Antimicrobial Resistance in Staphylococcus
- Pneumocystis jirovecii pneumonia detection and treatment
- Escherichia coli research studies
- Nosocomial Infections in ICU
- Influenza Virus Research Studies
- Bacterial Identification and Susceptibility Testing
- Pelvic floor disorders treatments
- Legionella and Acanthamoeba research
- Bacterial biofilms and quorum sensing
- Emergency and Acute Care Studies
- Antifungal resistance and susceptibility
- Microbial Metabolites in Food Biotechnology
- Pharmaceutical and Antibiotic Environmental Impacts
- Rabies epidemiology and control
Smolensk State Medical University
2017-2024
Children's City Clinical Hospital №11
2020
Background: Acinetobacter species other than A. baumannii are becoming increasingly more important as opportunistic pathogens for humans. The primary aim of this study was to assess the prevalence, distribution, antimicrobial resistance patterns, and carbapenemase gene content clinical non-baumannii (Anb) isolates that were collected part a sentinel surveillance program bacterial infections in hospitalized patients. secondary evaluate performance MALDI-TOF MS systems species-level...
Objective. To study the prevalence and mechanisms of antibiotic resistance, including carbapenemase production, in clinical isolates Klebsiella pneumoniae Escherichia coli isolated different regions Russia as part sentinel multicenter surveillance 2020–2021, to explore population structure K. impact “high-risk clones” on resistance. Materials Methods. Consecutive, non-duplicate (n = 2503) E. 2055) from various specimens (blood, cerebrospinal fluid, respiratory samples, urine, wound...
A high level of resistance to carbapenems in Acinetobacter baumannii strains severely limits therapeutic possibilities. Colistin is the last resort drug against such strains, although cases this have become more frequent. This article presents epidemiological features and genetic diversity colistin nonsusceptible A. collected as part a national multicenter study antibiotic pathogens nosocomial infections (MARATHON), which was conducted 2013-2014 Russia. total 527 isolates were collected, 10...
Objective. Objectives. To assess the rates of antibiotic resistance and production acquired carbapenemases in nosocomial strains Acinetobacter spp., to determine genotypes prevalence "international high-risk clones" among baumannii isolated various regions Russia within "MARATHON 2015–2016" study. Materials Methods. A total 1005 non-duplicate isolates including 975 A. baumannii, collected 44 hospitals from 25 cities 2015– 2016 were studied.
Objective. Objectives. To assess the rates of antibiotic resistance, production acquired carbapenemases, genotypes and prevalence «international high-risk clones» among nosocomial strains Pseudomonas aeruginosa isolated in various regions Russia within «MARATHON 2015–2016» study. Materials Methods. A total 1006 non-duplicate isolates P. collected 44 hospitals from 25 cities 2015–2016 were studied. Species identification was performed by means MALDI-TOF mass-spectrometry.
Aim: to study the etiology of severe community - acquired pneumonia (SCAP) in adults Russian Federation. SCAP is distinguished by high mortality and socio economic burden. Both antimicrobial resistance are essential for appropriate antibiotic choice. Materials methods. A prospective cohort recruited with confirmed diagnosis admitted multi word hospitals six cities 2014-2018. Etiology was routine culture blood, respiratory (sputum, endotracheal aspirate or bronchoalveolar lavage) when...
Objective. To evaluate in vitro activity of various macrolide antibiotics against a current collection clinical isolates Streptococcus pneumoniae and pyogenes isolated from patients with community-acquired infections different regions the Russian Federation. Materials Methods. A total 350 infections, including 200 S. 150 pyogenes, were included study. further 16-member macrolides erythromycin-resistant (MIC ≥ 0.5 mg/L), retrospective 253 112 was tested. Susceptibility to antimicrobials...
Objective. To evaluate antimicrobial resistance patterns of clinical Streptococcus pneumoniae isolates from different regions Russia during 2014–2017. Materials and Methods. We included in the study 519 S. 18 Russian cities. Susceptibility testing was performed by reference broth microdilution method (ISO 20776-1:2006). results were interpreted according to EUCAST v.9.0 breakpoints. Results. Using non-meningeal interpretation criteria, 65.1% tested susceptible (S) penicillin; addition 28.
Purpose: antigenic and genetic characterization of Streptococcus pneumoniae strains isolated from patients with invasive forms pneumococcal infection using whole-genome sequencing.Materials Methods. The study was performed on 46 S. during the PEHASus multicenter studies in 2015-2018. Sequencing Illumina protocols equipment. SPAdes, SeroBA, PneumoCaT software were used for data processing, as well BIGSdb (PubMLST.org).Results Discussion. Whole-genome sequences obtained; information entered...
A spectrum of causative bacterial pathogens
Objective. To study the antimicrobial susceptibility profile of Moraxella catarrhalis isolates from different regions Russia in 2010–2021. Materials and Methods. The included 352 M. isolated 11 cities (Volgograd, Irkutsk, Kazan, Kirov, Moscow, Murmansk, Perm, Seversk, Togliatti, Tomsk, Ulan-Ude) Identification was done by MALDI-TOF mass spectrometry. Antimicrobial testing determined broth microdilution method accordance with ISO 20776-1:2020. Interpretation results EUCAST guidelines...
Objective. To study in vitro activity of antimicrobials against clinical isolates obtained from patients with community-acquired urinary tract infections (UTIs) various regions Russia 2023. Materials and Methods. The included 1098 the urine children adults both sexes all age groups acute exacerbation recurrent UTIs, including pregnant women asymptomatic bacteriuria. Isolates were collected 29 centers 21 cities 2023 as part a multicenter prospective epidemiological dynamics antibiotic...
Objective. To evaluate antimicrobial resistance patterns of clinical Streptococcus pyogenes isolates from different regions Russia during 2014–2017. Materials and Methods. A total 792 S. 14 Russian cities were included in the study. Susceptibility testing was performed using reference broth microdilution method (ISO 207761:2006). results interpreted EUCAST v.10.0 breakpoints. Results. Penicillin G active against all tested with MIC50–90 values 0.016 mg/l highest MIC value 0.25 mg/l. No to...
The objective of this study was to characterize and compare antigenic genetic characteristics Streptococcus pneumoniae strains isolated from patients with invasive non-invasive pneumococcal infections (PIs) by using the data high-throughput sequencing.Materials methods. A total 158 S. were studied. All them during different stages PEHASus multicenter performed in 2015-2020. analysis based on information about whole-genome sequences 46 above study. Real-time PCR methods sequencing (the...
<b>Background:</b> Severe community-acquired pneumonia (SCAP) is distinguished by high mortality and socio-economic burden. Both etiology antimicrobial resistance (AMR) are essential for appropriate antibiotic choice. We aimed to study of SCAP in adults determine AMR among common pathogens. <b>Materials Methods:</b> A prospective cohort recruited with admitted multi-ward hospitals 2014-2018. Etiology was confirmed blood, respiratory culture, urinary antigen tests (L.pneumophila,...
Right-sided lesions caused by staphylococci are the most common clinical entity of infectious endocarditis (IE) among iv drug abusers. But some aspects epidemiological history critical in terms early detection uncommon pathogens.We describe a observation native aortic valve IE Pasteurella multocida 37-year-old female with heroin addiction, alcohol abuse and liver cirrhosis.She presented herself at our hospital acute fever, chills, subconjunctival petechial hemorrhages, traces scratches on...
Pneumococcal conjugate vaccines contain a limited number of serotype-specific antigens S. pneumoniae. It is important for vaccination programmes effectiveness assessment to control variety circulating pneumoniae serotypes. This review provides an analysis pneumococcal serotyping approaches and further ways improving serotype detection within the microbiological surveillance. Serological methods multiplex PCR can identify serotypes only. Whole-genome sequencing-based predict almost all...