A5053490658- Evolution and Genetic Dynamics
- Genetic diversity and population structure
- Environmental and Biological Research in Conflict Zones
- Chromosomal and Genetic Variations
- Genetic Associations and Epidemiology
- Zoonotic diseases and public health
- Animal Ecology and Behavior Studies
- Immune Response and Inflammation
- Genomics and Phylogenetic Studies
- Pneumonia and Respiratory Infections
- Biomarkers in Disease Mechanisms
- Nutrition, Genetics, and Disease
- Tuberculosis Research and Epidemiology
- Neurological Disorders and Treatments
- Cancer Genomics and Diagnostics
- Influenza Virus Research Studies
- Race, Genetics, and Society
- Streptococcal Infections and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Diet, Metabolism, and Disease
- Bioinformatics and Genomic Networks
- Healthcare Systems and Public Health
- Species Distribution and Climate Change
- Bacterial Infections and Vaccines
- Plant and animal studies
Central Research Institute of Epidemiology
2017-2024
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2017-2024
Institute of Gene Biology
2009-2024
Central Research Institute
2022
Science Research Laboratory
2021
Applied Research Laboratory at the University of Hawai‘i
2021
Medical Genetics Center
2021
Center for Personalized Cancer Treatment
2021
Moscow Clinical Scientific Center
2021
Russian Academy of Sciences
2006-2015
Hybrid parthenogenetic animals are an exceptionally interesting model for studying the mechanisms and evolution of sexual asexual reproduction. A diploid lizard Darevskia unisexualis is a result ancestral cross between maternal species raddei nairensis paternal valentini presents unique opportunity cytogenetic computational analysis hybrid karyotype. Our previous results demonstrated significant divergence pericentromeric DNA sequences parental species; however, in-depth comparative study...
The all-female Caucasian rock lizard Darevskia rostombekowi and other unisexual species of this genus reproduce normally via true parthenogenesis. Typically, diploid parthenogenetic reptiles exhibit some amount clonal diversity. However, allozyme data from D. have suggested that consists a single clone. Herein, we test hypothesis by evaluating variation at three variable microsatellite loci for 42 specimens four populations in Armenia. Analyses based on nucleotide polymorphisms each locus...
Unisexual all-female lizards of the genus Darevskia that are well adapted to various habitats known reproduce normally by true parthenogenesis. Although they consist unisexual lineages and lack effective genetic recombination, characterized some level polymorphism. To reveal mutational contribution overall variability, most straightforward conclusive way is direct detection mutation events in pedigree genotyping. Earlier we selected from genomic library D. unisexualis two polymorphic...
The extant reptiles are one of the most diverse clades among terrestrial vertebrates and a few groups with instances parthenogenesis. Due to hybrid origin parthenogenetic species, reference genomes parental species as well progeny indispensable explore genetic foundations reproduction. Here, we report on first genome assembly rock lizard Darevskia valentini, paternal for several lineages. novel was used in reconstruction comprehensive phylogeny Squamata inferred independently from 7369 trees...
Abstract Background The hybridization of female D. raddei and male valentini gave rise to the parthenogenetic Caucasian rock lizard Darevskia unisexualis . A previously identified genetic polymorphism in species consisted one common two allozyme clones. Analysis microsatellites single nucleotide polymorphisms (SNPs) from three yields estimates clonal diversity tests hypothesis a origin for Results Genotyping sequencing four microsatellite-containing loci 109 specimens , 17 valentini, 45...
Genetic factors in the HIV-background may play a significant role susceptibility to secondary diseases, like tuberculosis, which is leading cause mortality of HIV-positive people. Toll-like receptors (TLRs) are considered be for adaptive immunity, and polymorphisms TLR genes can influence activity immune response infection. We conducted case-control study association gene with risk tuberculosis coinfection multi-country sample participants. Our revealed certain associations between TLR4 TLR6...
Purpose: antigenic and genetic characterization of Streptococcus pneumoniae strains isolated from patients with invasive forms pneumococcal infection using whole-genome sequencing.Materials Methods. The study was performed on 46 S. during the PEHASus multicenter studies in 2015-2018. Sequencing Illumina protocols equipment. SPAdes, SeroBA, PneumoCaT software were used for data processing, as well BIGSdb (PubMLST.org).Results Discussion. Whole-genome sequences obtained; information entered...
Background: The progression of infectious diseases depends on the characteristics a patient’s innate immunity, and efficiency an immune system genetic factors, including SNPs in TLR genes. In this pilot study, we determined frequency alleles these subset patients with pneumonia. Methods: This study assessed six from genes: rs5743551 (TLR1), rs5743708, rs3804100 (TLR2), rs4986790 (TLR4), rs5743810 (TLR6), rs3764880 (TLR8). Three groups participated study: pneumonia 2019 (76 samples), caused...
Kidney stone disease is an urgent medical and social problem. Genetic factors play important role in the development. This study aims to establish association between polymorphisms genes coding for proteins involved calcium metabolism development of urolithiasis Russian population. In this case-control study, we investigated 50 patients with (experimental group) persons lacking signs kidney (control group). For molecular genetic analysis used a previously developed gene panel consisting 33...
The aim of the study was to determine molecular genetic prognostic criteria for severity course pneumonia based on analysis association polymorphism in toll-like receptors with NETosis.The included 38 patients main diagnosis community-acquired a severe course. All underwent standard clinical laboratory examinations, computed tomography thoracic organs, microbiological examination blood and tracheobronchial aspirate. level neutrophilic extracellular traps (NETs) smears determined 1st-2nd...
The first complete mitochondrial genome sequence of parthenogenetic Caucasian rock lizard Darevskia unisexualis (Lacertidae family) is determined by hybrid assembly with Illumina HiSeq and PacBio RS II platforms. circular 21.4 kbp mitogenome contains 13 protein-coding genes, 12S 16S rRNA 20 tRNAs, two pseudogenized one long tandem repeats 4.1 length formed 59 bp monomer repeated x70.6 times located before control region. This finding represents a new example variation in lizards origin,...
To develop a method of the complex assessment genetic risk for ischemic stroke (IS) and evaluate its effectiveness.Genotyping 182 patients with atherothrombotic cardioembolic subtypes IS 360 healthy individuals 48 single nucleotide polymorphic loci (SNP) associated II was performed.In each group SNPs, composite indicators in groups controls were identified. Differences between calculated values these significant (p <0,05). The quality binary classification validated by ROC-analysis confirmed...
There is evidence of the role microorganisms in endothelial damage and, as a consequence activation blood coagulation pathways, thrombosis, which turn one risk factors for development acute cerebrovascular accidents (ACVA). Objective. To analyze microbiological profile DNA isolated from thrombus patients with ACVA. Materials and methods. Fifty-seven samples obtained lifetime vessels ischemic-type ACVA during thrombectomy thrombaspiration were selected study. All period coronavirus infection...