A5063862378- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Genetic diversity and population structure
- Plant Virus Research Studies
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Evolution and Paleontology Studies
- Photosynthetic Processes and Mechanisms
- RNA Research and Splicing
- Protist diversity and phylogeny
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Legume Nitrogen Fixing Symbiosis
- Genomic variations and chromosomal abnormalities
- Ichthyology and Marine Biology
- Carbohydrate Chemistry and Synthesis
- Evolution and Genetic Dynamics
- Bacteriophages and microbial interactions
- Genetics, Aging, and Longevity in Model Organisms
- Identification and Quantification in Food
- Bat Biology and Ecology Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Origins and Evolution of Life
- Diatoms and Algae Research
Engelhardt Institute of Molecular Biology
2007-2024
Institute of Gene Biology
1999-2023
Russian Academy of Sciences
2009
Lomonosov Moscow State University
1990-1991
SINEBase (http://sines.eimb.ru) integrates the revisited body of knowledge about short interspersed elements (SINEs). A set formal definitions concerning SINEs was introduced. All available sequence data were screened through these and genetic misidentified as discarded. As a result, 175 SINE families have been recognized in animals, flowering plants green algae. These classified by modular structure their nucleotide sequences frequencies different patterns evaluated. formed basis for...
Half of the human genome consists repetitive DNA sequences. Recent studies in various organisms highlight role chromatin regulation gene as well maintainance chromosomes and integrity. Hence, sequences might be potential "sensors" for changes associated with pathogenesis. Therefore, we developed a new genomic tool called RepArray. RepArray is repeat-specific microarray composed representative set repeated including transposon-derived repeats, simple tandemly such centromeres telomeres. We...
Band shift assays were used to study proteins from the fission yeast that bind double-stranded telomeric repeat sequences. We also examine general DNA binding properties of telobox domain, which characterizes telomere-binding a range species. demonstrate Taz1p has high affinity for repeat, consistent with genetic results implicating this protein in telomere maintenance. A second Schizosaccharomyces pombe protein, Teb1p, is shown vertebrate and low DNA. When tested on G-rich singlestranded...
SINEs, non-autonomous short retrotransposons, are widespread in mammalian genomes. Their transcripts generated by RNA polymerase III (pol III). Transcripts of certain SINEs can be polyadenylated, which requires polyadenylation and pol termination signals their sequences. Our sequence analysis divided Can canids into four subfamilies, older a1 a2 younger b1 b2. Can_b2 to a lesser extent Can_b1 remained retrotranspositionally active, while the amplification Can_a1 Can_a2 ceased long ago. An...
Short Interspersed Elements (SINEs) are eukaryotic non-autonomous retrotransposons transcribed by RNA polymerase III (pol III). The 3′-terminus of many mammalian SINEs has a polyadenylation signal (AATAAA), pol transcription terminator, and A-rich tail. RNAs such can be polyadenylated, which is unique for transcripts. Here, B2 (mice related rodents), Dip (jerboas), Ves (vespertilionid bats) SINE families were thoroughly studied. They divided into subfamilies reliably distinguished relatively...
Recent metagenomic studies in insects identified many sequences unexpectedly closely related to plant virus genes. Here we describe a new example of this kind, insect R1 LINEs with an additional C-terminal domain their open reading frame 2. This is similar NTPase/helicase (SF1H) domains, which are found replicative proteins encoded by viruses the genus Tobamovirus. We hypothesize that SF1H could be acquired LINEs, directly or indirectly, upon feeding on virus-infected plants. Possible...
Short Interspersed Elements (SINEs) are eukaryotic retrotransposons transcribed by RNA polymerase III (pol III). Many mammalian SINEs (T+ SINEs) contain a polyadenylation signal (AATAAA), pol transcription terminator, and an A-rich tail in their 3′-end. The RNAs of such have the capacity for AAUAAA-dependent polyadenylation, which is unique to III-generated transcripts. structure, evolution, Ere SINE ungulates (horses, rhinos, tapirs) were investigated this study. A bioinformatics analysis...
Abstract Families of Short Interspersed Elements (SINEs) originate from tRNA, 5S rRNA, and 7SL RNA molecules in the genomes multicellular organisms. RNA-derived SINEs are very rare; however, they have been best studied primates rodents. The rodent B1 SINE is a monomeric element, whereas primate Alu composed two monomers.We found that contrast to other members family Talpidae (moles), which possess tRNA-derived Tal SINE, shrew mole Uropsilus gracilis contains 280,000 genomic copies previously...
Abstract Background The genomes of many eukaryotes contain DNA repeats in the form both tandem and interspersed elements with distinct structure, evolutionary histories, mechanisms emergence amplification. Although there is considerable knowledge regarding their diversity, little evidence directly linking these two types. Results Different derived from portions short (SINEs) belonging to different families were identified 56 squamate reptiles. All loci SINE-derived satellites (sSats)...