A5080842307- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Yersinia bacterium, plague, ectoparasites research
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Mycobacterium research and diagnosis
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial Infections and Vaccines
- Enterobacteriaceae and Cronobacter Research
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Escherichia coli research studies
- Security, Politics, and Digital Transformation
Smolensk State Medical University
2012-2024
Objective. To assess rates of antimicrobial resistance and production the clinically important acquired mechanisms (extended spectrum beta-lactamases [ESBL] carbapenemases) in nosocomial strains Enterobacterales, to determine genotypes prevalence "international high-risk clones" among carbapenemase-producing Klebsiella pneumoniae isolated various Russian regions within "MARATHON 2015–2016" study. Materials Methods. A total 2786 non-duplicate isolates including 1316 K. 837 Escherichia coli 49...
Background: Acinetobacter species other than A. baumannii are becoming increasingly more important as opportunistic pathogens for humans. The primary aim of this study was to assess the prevalence, distribution, antimicrobial resistance patterns, and carbapenemase gene content clinical non-baumannii (Anb) isolates that were collected part a sentinel surveillance program bacterial infections in hospitalized patients. secondary evaluate performance MALDI-TOF MS systems species-level...
Objective. To study the prevalence and mechanisms of antibiotic resistance, including carbapenemase production, in clinical isolates Klebsiella pneumoniae Escherichia coli isolated different regions Russia as part sentinel multicenter surveillance 2020–2021, to explore population structure K. impact “high-risk clones” on resistance. Materials Methods. Consecutive, non-duplicate (n = 2503) E. 2055) from various specimens (blood, cerebrospinal fluid, respiratory samples, urine, wound...
A high level of resistance to carbapenems in Acinetobacter baumannii strains severely limits therapeutic possibilities. Colistin is the last resort drug against such strains, although cases this have become more frequent. This article presents epidemiological features and genetic diversity colistin nonsusceptible A. collected as part a national multicenter study antibiotic pathogens nosocomial infections (MARATHON), which was conducted 2013-2014 Russia. total 527 isolates were collected, 10...
Objective. Objectives. To assess the rates of antibiotic resistance and production acquired carbapenemases in nosocomial strains Acinetobacter spp., to determine genotypes prevalence "international high-risk clones" among baumannii isolated various regions Russia within "MARATHON 2015–2016" study. Materials Methods. A total 1005 non-duplicate isolates including 975 A. baumannii, collected 44 hospitals from 25 cities 2015– 2016 were studied.
Objective. Objectives. To assess the rates of antibiotic resistance, production acquired carbapenemases, genotypes and prevalence «international high-risk clones» among nosocomial strains Pseudomonas aeruginosa isolated in various regions Russia within «MARATHON 2015–2016» study. Materials Methods. A total 1006 non-duplicate isolates P. collected 44 hospitals from 25 cities 2015–2016 were studied. Species identification was performed by means MALDI-TOF mass-spectrometry.
Objective. To assess the prevalence and antimicrobial susceptibility of carbapenemase-producing Enterobacterales (CPE). Materials Methods. A total 5539 isolates recovered from hospitalized patients in 52 medical institutions 27 cities Russia 2014-2016 were tested. Antibiotic testing (AST) was performed using broth microdilution method according to ISO 20776-1:2006. Avibactam tested combinations with beta-lactams at fixed concentration 4 mg/l. AST results interpreted EUCAST v8.
Pseudomonas aeruginosa is recognized as one of the six most important pathogens in terms antimicrobial resistance («ESKAPE» pathogens), and included by WHO group microorganisms for which need development new agents crucial. In 2015, P. was second (after Klebsiella spp.) common nosocomial bacterial pathogen Russia with following rates: amikacin – 45.2%, imipenem 51.5%, meropenem 53.3%, colistin 2.2%, piperacillin/tazobactam 61.4%, ceftazidime 56.8%, ciprofloxacin 61.2%. The majority...
Objective. To assess the in vitro activity of ceftazidime-avibactam against clinical Enterobacterales and Pseudomonas aeruginosa isolates various regions Russia based on results local susceptibility testing by disk diffusion method. Materials Methods. Overall, 160 laboratories located 61 Russian cities participated this surveillance during 2018-2020. All consecutive each participating laboratory were included study. Ceftazidime-avibactam was done disc-diffusion method accordance with current...
The purpose of the study was to evaluate frequency isolation multi-resistant Pseudomonas aeruginosa and identify mechanisms resistance carbapenems. Material methods. We analyzed 866 strains Pseudomonos aeruginosaisolated from clinical samples cancer patients in period 2014–2016. level piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin dynamics determined. carbapenem-resistant (car-R) were examined for presence enzymes. Results. Between 2014 2016,...
The purpose of the study was to evaluate frequency isolation multi-resistant Acinetobacter baumannii in cancer patients and identify mechanisms resistance carbapenems. Material Methods. We analyzed 942 strains A. isolated from clinical samples period 2014–16. level ampicillin-sulbactam, piperacillin-tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin, other antibiotics determined. Carbapenem-resistant (Car-R) were examined for presence carbapenemases. Results ....
Objective. To determine in vitro activity of oral III generation cephalosporin cefpodoxime against clinical isolates Haemophilus influenzae, Streptococcus pneumoniae and pyogenes isolated from patients with community-acquired respiratory tract infections different regions the Russian Federation. Materials Methods. The study included bacterial pathogens outpatients hospitalized A total 558 were study, including 184 H. 186 S. 188 pyogenes. Species identification was performed using MALDI-TOF...
MALDI-TOF mass spectrometry has become widely used in clinical microbiology and proved highly accurate for detection of carbapenemases Gram-negative bacteria. However, the use carbapenem-hydrolysis assays routine diagnostics is hampered by need antibiotic substances making their fresh solutions each time an assay conducted. Here, we evaluated commercial susceptibility-testing disks as source ertapenem substrate MS-based carbapenemase-producing Enterobacterales (CPE). The was validated on 48...