A5050027491- Urinary Tract Infections Management
- Pediatric Urology and Nephrology Studies
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Pelvic floor disorders treatments
- HIV Research and Treatment
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Infectious Disease Case Reports and Treatments
- CRISPR and Genetic Engineering
- Medical Device Sterilization and Disinfection
- Respiratory and Cough-Related Research
- Bacterial Identification and Susceptibility Testing
- Histone Deacetylase Inhibitors Research
- Vibrio bacteria research studies
- Dermatological and COVID-19 studies
- Bacterial biofilms and quorum sensing
- Drug-Induced Adverse Reactions
- Urinary Bladder and Prostate Research
- Long-Term Effects of COVID-19
- Nephrotoxicity and Medicinal Plants
- Escherichia coli research studies
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Pharmaceutical Practices and Patient Outcomes
Smolensk State Medical University
2003-2024
Ministry of Health of the Russian Federation
2021
Fox Chase Cancer Center
2007
ABSTRACT A total of 904 consecutive nosocomial isolates Escherichia coli and Klebsiella pneumoniae collected from 28 Russian hospitals were screened for production extended-spectrumβ -lactamases (ESBLs). The ESBL phenotype was detected in 78 (15.8%) E. 248 (60.8%) K. isolates. One hundred fifteen carried the genes CTX-M-type β-lactamases, which, as shown by PCR-restriction fragment length polymorphism analysis, distributed into two genetic groups CTX-M-1 (93%)- CTX-M-2 (7%)-related enzymes....
• Resistance to nitrofurantoin, fosfomycin and mecillinam was <10% for E. coli isolates. Viable first-line treatments were not always available. Trimethoprim Trim/sulfa recommended as despite high resistance. Over-the-counter sales of furazidin could explain higher resistance nitrofurantoin. Russian patients had a risk outpatient UTI caused by resistant . In the Northern Dimension Antibiotic Study (NoDARS), Finland, Germany, Latvia, Poland, Russia Sweden collected urine samples from women...
Objective. To study in vitro activity of antimicrobials against clinical isolates from patients with communityacquired urinary tract infections (UTIs) different regions Russia 2017–2018. Materials and Methods. A total 1052 Enterobacterales collected the Russian Federation as part a multicenter, prospective, epidemiological antimicrobial resistance uropathogens causing community-acquired UTI subsets ("DARMIS-2018") were included analysis. Uropathogens isolated children adults both sexes all...
Integrated retroviral DNA is subject to epigenetic gene silencing, resulting in loss of expression viral genes as well reporter or therapeutic transduced by vectors. Possible mediators such silencing include the histone deacetylase (HDAC) family cellular proteins. We previously isolated HeLa cell populations that harbored silent avian sarcoma virus-based green fluorescent protein (GFP) vectors could be reactivated treatment with HDAC inhibitors. Here, we developed a small interfering RNA...
We investigated the faecal carriage prevalence of extended-spectrum β-lactamase production in Escherichia coli (EP-EC) and/or Klebsiella pneumoniae (EP-KP) and risk factors associated with among adult study subjects Finland, Germany, Latvia, Poland, Russia Sweden (partner countries). The aim was to get indicative data on ESBL-carriage specific populations region. Faecal samples were collected from four screened ChromID-ESBL ChromID-OXA-48 plates. Positive isolates further characterised...
Integrated retroviral DNA is subject to epigenetic gene silencing, but the viral and host cell properties that influence initiation, maintenance, reactivation are not fully understood. Here we describe rapid high-frequency repression silencing of integrated avian sarcoma virus (ASV)-based vector DNAs in human HeLa cells. Initial studies utilized a carrying strong cytomegalovirus (hCMV) immediate-early (IE) promoter drive expression green fluorescent protein (GFP) reporter gene, cells were...
To study in vitro activity of antimicrobials against clinical isolates from patients with community-acquired urinary tract infections (UTIs) different regions Russia, Belarus and Kazakhstan 2017-2018.A total 1260 collectedin the Russian Federation, Kazakhstanas a part international multicenter prospective epidemiological dynamics antimicrobial resistance uropathogens causing subsets ("DARMIS-2018") were included analysis. 1124 strains represented Enterobacterales order. Uropathogenswere...
Objectives: The REWIND study sought to describe the real-world clinical and prescribing practices for management of urinary tract infection (UTI) in Italy, Belgium, Russia Brazil order compare current with international, European national guidelines. Methods: An integrated mixed-methods approach was adopted that used information from primary care electronic medical records longitudinal patient databases available Italy surveys physicians (general practitioners) (gynaecologists). Results: In...
COVID-19 has had a significant impact on health care systems, including drug use. The present study aimed to evaluate the patterns of community supply antimicrobials from pharmacies during pandemic in five cities Russia. In cross-sectional study, random sample reported all episodes one-week period. Patterns (age and gender customer, name formulation, prescription availability, indication, etc.) were analyzed. Altogether, 71 took part 5270 encounters recorded. total, 4.2% visits resulted more...
The study aimed to investigate behaviour, knowledge and practices towards antibiotic (AB) use among patients who purchased ABs with a prescription across Russia.
We report a Russian case of 61-year-old male patient with confirmed COVID-19 infection who developed nosocomial pneumonia complicated by lung abscess associated multi-drug-resistant isolates
Objective. To study in vitro activity of antimicrobials against clinical isolates obtained from patients with community-acquired urinary tract infections (UTIs) various regions Russia 2023. Materials and Methods. The included 1098 the urine children adults both sexes all age groups acute exacerbation recurrent UTIs, including pregnant women asymptomatic bacteriuria. Isolates were collected 29 centers 21 cities 2023 as part a multicenter prospective epidemiological dynamics antibiotic...
Background. The inappropriate and overuse of antimicrobials is a problem worldwide. To target future interventions, thorough understanding current behavior reasons needed. aim the study was to explore antibiotic knowledge, attitudes, behaviors among patients residing in Russia. Methods. In total, 149 semistructured interviews were carried out with respondents using antibiotics without prescriptions. Interviews used assess participants’ practices treat symptoms confirmed/suspected infectious...
Cephalosporins are one of the most commonly used antimicrobials for treatment variety bacterial infections. Prudent use third-generation cephalosporins is important control spread cephalosporin-resistant Gram-negative bacteria, especially ESBL-producing *Enterobacterales* strains. One therapeutic areas where balance between clinical efficacy and antimicrobial resistance critical importance urinary tract Current review summarizes existing data on oral in infections with a special emphasis to...
Proper antibiotic usage education and training of medical students healthcare professionals is the cornerstone to implement antimicrobial stewardship (AMS) programs worldwide. We conducted this voluntary anonymous survey on current preferred educational provision AMS in Russia. Among 1358 polled respondents from six participating Centers located geographically remote Federal Districts Russia, majority were nurses (52.8%) doctors (42.0%). Results demonstrated better coverage an undergraduate...
The title of this review “War and peace” is not accidental the analogies with a well-known literary masterpiece have absolutely justified ground. As in case Lev Tolstoy’s novel has profound philosophical meaning, although at first glance it may seem quite obvious. word «war» well correspond to those hostile changes microorganisms leading current problem antimicrobial resistance recognized worldwide. This “war” we wage against antibiotic-resistant bacteria today. And «peace» context...
The increase in infections caused by multidrug-resistant microorganisms is currently one of the most serious medical issues. In fact, antimicrobial resistance viewed World Health Organization as threats to health worldwide. problem exacerbated lack new antibiotics with respective benefits for treatment bacteria. While compounds are being developed a number "old" used clinical practice several decades may acquire indications use.