Relevance. Chronic cerebral ischemia is a collective term describing various brain vascular lesions that develop without stroke. For neuroprotective action and correction of cognitive impairment by acting on AMPA receptors, calcium salt N- (5-hydroxynicotinoyl) — L-glutamic acid was synthesized. The effectiveness safety these drugs were initially demonstrated in biological models further confirmed patients with chronic circulatory disorders. Objective. To determine the optimal drug therapy...

Rheumatoid arthritis (RA) is a multifactorial incurable immune-inflammatory disease. Progression leads to joint deformation, cartilage and bone tissue destruction, subsequent disability. The primary goal of RA pharmacotherapy achieve disease remission. For this purpose, several classes drugs are used: basic anti-inflammatory (DMARDs), which large group synthetic biological that combined according their ability influence the pathogenetic mechanisms RA; glucocorticoids, recommended for use in...

Relevance. The selection and modification of drug therapy for patients with plaque psoriasis does not have a specific solution practicing specialists. Factors been identified that can worsen the course disease when therapies proven clinical efficacy are used even increase severity prevalence psoriatic process, leading to development erythroderma or resistance therapy. This article analyzed actual practice influence concomitant diagnoses on choice by physicians among who were treated in skin...

INTRODUCTION. The administration of 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide (TFISA) into the eyes can reduce intraocular pressure. Currently, this novel selective carbonic anhydrase II inhibitor is at preclinical research stage. excretion TFISA and its metabolites has not been studied yet. AIM. This study aimed to calculate parameters urinary faecal major in rats. MATERIALS AND METHODS. was performed 6 Wistar rats (3 males 3 females). received an instillation 1%...

В статье предложено определение (дефиниция) понятия «эффективность». Эффективность - это категория, характеризующая способность явления (процесса, системы) произвести (генерировать) эффект в соответствии с определенным объемом потребленных ресурсов или понесенных затрат конкретных границах пространства и времени. The article proposes a definition (definition) of the concept "efficiency". Efficiency is category that characterizes ability phenomenon (process, system) to produce (generate) an...

The article describes the concept of development patient-oriented medicine and pharmacy in Russian Federation.

Introduction: 3-(2-butyl-5-chloro-1H-imidazole-4-yl)-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,2-oxazole-5-carboxamide is new antirheumatic drug. It necessary to identify and synthesize the biotransformation products for its complete pharmacokinetic study. Materials Methods: A study was carried out by intraperitoneal administration of drug Wistar rats Soviet Chinchilla breed rabbits. Animal blood sampling performed before injection 0.5 h, 1 2 4 24 h after investigated compound....

Tuberculosis is a chronic infectious disease, usually localized in the respiratory system and representing one of most important global social biomedical health problems associated with spread therapy-resistant forms (multidrug-resistant extensively drug-resistant tuberculosis). One promising targets for development antimycobacterial drugs enzyme DprE1, which involved synthesis cell wall mycobacteria. In series DprE1 inhibitor drugs, advanced drug PBTZ169 (INN maсozinone). Clinical trials...

Introduction: Development of new bioanalytical methods is required for studying the systemic exposure selective inhibitor carbonic anhydrase II, 4-(2-methyl-1,3-oxazole-5-yl)-benzenesulfonamide, and its N-hydroxymetabolite in plasma whole blood. The results experiment with a single administration an ophthalmic suspension drug are necessary to optimize subsequent design full pharmacokinetic study. Materials Methods: HPLC-MS/MS method was used measure concentration analytes Chromatographic...

COVID-19 has had a significant impact on health care systems, including drug use. The present study aimed to evaluate the patterns of community supply antimicrobials from pharmacies during pandemic in five cities Russia. In cross-sectional study, random sample reported all episodes one-week period. Patterns (age and gender customer, name formulation, prescription availability, indication, etc.) were analyzed. Altogether, 71 took part 5270 encounters recorded. total, 4.2% visits resulted more...

INTRODUCTION. Systemic exposure studies of a selective carbonic anhydrase II inhibitor, the isoxazole derivative 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide (TFISA), require evaluating its pharmacokinetics in whole blood because compound can accumulate erythrocytes. Currently, no bioanalytical procedures have been developed to achieve this. AIM. This study aimed develop procedure for determination TFISA and metabolites...

Relevance . Therapy of hemophilia A, B and Willebrand's disease is carried out under the program 14 VZN due to use federal budget funds. The funding increasing in line with growth total number patients. In 2022,85.99 billion rubles were allocated, which corresponds a 1.5‑fold increase compared 2018. aim study was conduct an economic analysis drugs for therapy disease. Methods materials dosing regimen LPs selected on basis clinical recommendations, availability program, prices from State...

It is important for public health to monitor and improve the indicators of population using system patient's quality life (HRQoL) assessment regardless nosology disease. The use HRQoL provides authorities with a tool additional analysis performance services making decisions about funding priorities. definition one decisive factors in calculation QALYs because it measures effectiveness medical treatment terms how much prolongs and/or improves patients' lives. aim study determine hemophilia...

Background . Determining changes in the content of monoamine neurotransmitters and their metabolites brain structures is a necessary part studying pharmacodynamics antiparkinsonian drugs. A method for joint determination norepinephrine, adrenaline, dopamine, serotonin, 5-hydroxyindole-3-acetic acid, 3,4-dihydroxyphenylacetic homovanillic vanillylmandelic acid rat tissue has not previously been developed. The aim study To develop to validate quantitative 5-hydroxyindole3-acetic using...

Evaluation of the bioequivalence tested Relonova, tablets, 10 mg and Maxalt, drugs on an empty stomach in healthy volunteers.The pharmacokinetic analysis population included 40 volunteers, safety volunteers. The average age randomized volunteers (men - 20, women 20) was 29.3±8.9 years, height 1.71±0.09 m, body weight 70.86±11.66 kg, mean BMI 24.18±2.81 kg/m2. method used high performance liquid chromatography with tandem mass spectrometric detection. Statistical obtained data performed based...

Introduction: The determination of biotransformation products is an essential part the preclinical trial original medicines. These studies have not been conducted before for new drug 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide. Identification and synthesis metabolite substances are necessary subsequent tests bioavailability, linearity pharmacokinetics, accumulation, distribution excretion. Materials methods: study was carried out on Wistar rats rabbits Soviet Chinchilla...

Results of a randomized, double-blind pilot study indicate that transcranial electrotherapy stimulation may be an effective treatment for the temporary reduction pain in osteoarthritis patients. Presently, predominant method management is medication. One very different approach application micro- to milliamp current applied specific areas head, resulting release endogenous opioids from regions brain. For study, 64 subjects suffering knee and/or hip were enrolled. two weeks prior, then during...

Aim: To compare safety (immunogenicity) and efficacy of GP40061 insulin glargine (GP-Gla) Lantus® (Sanofi glargine, Sa-Gla) in people with diabetes mellitus. Materials & methods: This randomized open-label, 26-week clinical trial enrolled 180 Type 1 mellitus patients (HbA1c 6.5-12.0%), 1:1 to once daily GP-Gla (n = 90) or Sa-Gla 90). The primary end point was immune response at 26th week. Results: frequency similar (p 1.000). Groups were terms other points. Mean HbA1c change from baseline...

Comparative assessment of the pharmacokinetic properties and bioequivalence (BE) two methyldopa formulations (Methyldopa, 250 mg tablets, R-Pharm CJSC, Russia-investigational medicinal product, Dopegyt®, EGIS Pharmaceuticals PLC, Hungary-reference product) were investigated in 24 healthy volunteers (13 women 11 men, caucasian) an open-label, randomized, crossover, two-period, two-sequence trial with 7-day washout period. A comparative dissolution test was carried out advance 3 media,...

The goal — a scientific evaluation of the effectiveness and safety NHS in treatment experimental drug-resistant tuberculosis. Materials methods. Used silver nanoparticles obtained by an electrochemical method. With size 5-60 nm, 120-270 kontsentratsiey- 1 mcm² stabilizer shell 2-5 nm. 750 crops studied Inhibitory activity isolated form as part nanocomposite with chemotherapy concentrations 5; 25 50 mcg/ml. Defines minimum inhibitory concentration bactericidal composed isoniazid. To evaluate...