Abstract Prostate cancer is the second most common globally in men, and some countries now diagnosed form of cancer. It necessary to differentiate between benign malignant prostate conditions give accurate diagnoses. We aim demonstrate use a 3D Mueller matrix method allow quick easy clinical differentiation adenoma carcinoma tissues with different grades Gleason scores. Histological sections tumours, obtained by radical prostatectomy, were investigated. map degree depolarisation tumour using...

Abstract Layered topographic maps of the depolarisation due to diffuse biological tissues are produced using a polarisation-holographic Mueller matrix method approach. Histological sections myocardial tissue with spatially structured optically anisotropic fibrillar network, and parenchymal liver polycrystalline island structure successfully mapped. The topography myocardium relates scattering multiplicity within volume specific morphological structures crystallite networks. overall map is...

The decomposition of the Mueller matrix blood films has been carried out using differential matrices with polarized and depolarized parts. use a coherent reference wave is applied algorithm digital holographic reconstruction field complex amplitudes used. On this basis, 3D Mueller-matrix diffuse tomography method—the distributions fluctuations linear circular birefringence depolarizing polycrystalline human analytically justified experimentally tested. dynamics change in magnitude...

We introduce a Mueller-matrix imaging polarization-based approach for the quantitative digital screening of polycrystalline structure fibrillary-based biological tissues in vitro. The morphometric evaluation histological sections myocardium was performed utilizing high-order statistical moments calculated based on spatial distribution linear and circular birefringence dichroism obtained experimentally. demonstrate that distributions phase light optical anisotropy scattering inherent to...

SignificanceMueller-matrix polarimetry is a powerful method allowing for the visualization of malformations in biological tissues and quantitative evaluation alterations associated with progression various diseases. This approach, fact, limited observation spatial localization scale-selective changes poly-crystalline compound tissue samples.AimWe aimed to improve Mueller-matrix approach by implementing wavelet decomposition accompanied polarization-singular processing express differential...

SignificanceThe interference-holographic method of phase scanning fields scattered laser radiation is proposed. The effectiveness this for the selection variously dispersed components demonstrated. This made it possible to obtain polarization maps biological tissues at a high level depolarized background. scale-selective analysis such was used determine necrotic changes in optically anisotropic architectonics tissues.ObjectiveDevelopment and experimental approbation layered polarimetry...

Abstract This study introduces a novel approach in the realm of liquid biopsies, employing 3D Mueller-matrix (MM) image reconstruction technique to analyze dehydrated blood smear polycrystalline structures. Our research centers on exploiting unique optical anisotropy properties proteins, which undergo structural alterations at quaternary and tertiary levels early stages diseases such as cancer. These manifest distinct patterns microstructure dried droplets, offering minimally invasive yet...

Using optical techniques for tissue diagnostics (so-called 'optical biopsy') has been a subject of extensive research many years. Various groups have exploring different spectral and/or imaging modalities (e.g. diffuse reflectance spectroscopy, autofluorescence, Raman coherence tomography (OCT), polarized light microscopy, etc.) biomedical applications. In this paper, we report on using multi-wavelength Mueller polarimetry combined with an appropriated image post-processing the detection...

Utilizing Stokes-correlometry analysis a new diagnostic approach has been introduced for quantitative assessment of polarization images histological sections optically anisotropic biological tissues with different morphological structures and physiological conditions. The developed is based on the coordinate phase distributions Stokes vector scattered light. A combined use statistic, correlation, fractal used resolving variations in optical anisotropy samples. proposed application...

Current research presents the results of investigation diagnostic efficiency laser polarization autofluorescence for set endogenous fluorophores blood plasma polycrystalline films in two spectral regions (0.5–0.53 μm and 0.63–0.67 μm) under excitation radiation with a wavelength 0.405 μm. A model generalized optical anisotropy protein networks is proposed purpose defining processes. Both phase (linear birefringence activity) amplitude circular dichroisms) anisotropies have been considered....

This research presents investigation results of the diagnostic efficiency an azimuthally stable Mueller-matrix method analysis laser autofluorescence polycrystalline films dried uterine cavity peritoneal fluid. A model generalized optical anisotropy fluid is proposed in order to define processes autofluorescence. The influence complex mechanisms both phase (linear and circular birefringence) amplitude dichroism) anisotropies taken into consideration. interconnections between elements...

Algorithms for reconstruction of linear and circular birefringence-dichroism optically thin anisotropic biological layers are presented. The technique Jones-matrix tomography polycrystalline films fluids various human organs has been developed experimentally tested. coordinate distributions phase amplitude anisotropy bile synovial fluid taken from the knee joint determined statistically analyzed. Criteria (statistical moments 3rd 4th orders) differential diagnostics early stages...

Abstract We introduce a method of azimuthally invariant 3D Mueller-matrix (MM) layer-by-layer mapping the phase and amplitude parameters anisotropy partially depolarizing layers benign (adenoma) malignant (carcinoma) prostate tumours. The technique is based on analysis spatial variations Mueller matrix (MMI) histological sections tissue samples. dependence magnitudes first-to-fourth order statistical moments applied to characterize distributions MMI linear circular birefringence dichroism...

The article describes a technique for digital holographic reconstruction of complex amplitude fields in diffuse blood facies using laser polarization-interference phase scanning to isolate single scattered component the object field. This method serves as basis developing algorithms Mueller-matrix linear and circular birefringence parameters polycrystalline architectonics facies. Statistical (central moments 1st-4th orders) multifractal analyses (fractal dimension spectra) are applied study...

Journal of Innovative Optical Health SciencesAccepted Papers Open AccessPhase waves local depolarization in biological tissues object speckle fields. Fundamental and applied aspectsYurii Ushenko, Alexander Dubolazov, Mykhaylo Gorsky, Irina Soltys, Olexandra Litvinenko, Victor Bachinsky, Ivan Mikirin, Olexander Salega, Garasim, Jun Zheng, Lin BinYurii Ushenko Search for more papers by this author , Dubolazovhttps://orcid.org/0000-0003-1051-2811 Gorskyhttps://orcid.org/0000-0001-6806-288X...

This study focuses on the topographic structure of optical anisotropy maps (theziograms) dehydrated blood plasma films (facies) to identify and utilize markers for diagnosing self-similarity (multifractality) in birefringence parameters supramolecular protein networks. The research is based Jones-matrix analytical framework, which describes formation polarization-structural speckle fields polycrystalline facies. In proposed model, algorithms were developed relate real imaginary parts complex...

In recent years, modern non-destructive and non-invasive methods of optical diagnostics biological tissue fluid preparations have become widely effectively used in various branches medicine. Among the wide range methods, one most effective has been distinguished - laser polarimetric polycrystalline structure layers. The purpose tasks research. To experimentally test determine a set markers for differential diagnosis cause death due to formation hemorrhages traumatic non-traumatic genesis...

We have theoretically grounded conceptions of characteristic points observed in coordinate distributions Mueller matrix elements for a network human tissue biological crystals. The interrelation between polarization singularities laser images inherent to these crystals and values above is found. determined the criteria statistical diagnostics pathological changes birefringent structure crystal by using myometrium as an example.

The model of a Mueller matrix description mechanisms optical anisotropy typical for polycrystalline films blood plasma--optical activity, birefringence, as well linear and circular dichroism--is suggested. On this basis, the algorithms reconstruction parameters distribution (polarization plane rotations, phase shifts, coefficients dichroism) indicated types were found different spectrally selective ranges. Within statistical analysis such distributions, objective criteria differentiation...

The model of generalized optical anisotropy human bile is suggested, and the method polarimetric phase Fourier transform image laser radiation field that generated by mechanisms linear circular birefringence polycrystalline networks with a wavelet-diagnosis cholelithiasis analytically substantiated.

We present in this work the results of an investigation to analyse coordinate distributions azimuths and ellipticity polarization (polarization maps) laser images blood plasma layers for three groups patients: healthy (group 1), mastopathy 2) breast cancer 3). To characterize maps all samples we use parameters: statistical moments first fourth orders, autocorrelation functions logarithmic dependences power spectra related inherent plasma. ascertain criteria diagnosis differentiation...

We propose an optical model of the Mueller-matrix description mechanisms anisotropy polycrystalline films urine, namely, activity and birefringence. The algorithm reconstruction distributions parameters-optical rotation angles phase shifts indicated types-are elaborated upon. objective criteria differentiation urine taken from healthy donors albuminuria patients by means statistical analysis such are determined. operational characteristics (sensitivity, specificity, accuracy) method...