A5033628913- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Advanced Chemical Sensor Technologies
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- MicroRNA in disease regulation
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- ECG Monitoring and Analysis
- Metabolomics and Mass Spectrometry Studies
- Atrial Fibrillation Management and Outcomes
- Advanced X-ray and CT Imaging
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Healthcare Systems and Public Health
- Cancer-related molecular mechanisms research
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Bipolar Disorder and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Antiplatelet Therapy and Cardiovascular Diseases
- Circular RNAs in diseases
- Inhalation and Respiratory Drug Delivery
Sechenov University
2014-2025
Institute for Systems Analysis
2024
Russian Academy of Sciences
2024
Harbin Medical University
2023
Lomonosov Moscow State University
2023
Royal Brompton Hospital
2019
Université Paris Cité
2019
Assistance Publique – Hôpitaux de Paris
2019
Hôpital Bichat-Claude-Bernard
2019
Inserm
2019
Abstract Emerging evidence has suggested the critical role of endothelial to mesenchymal transition (EndMT) in fibrotic diseases. The present study was designed examine whether EndMT is involved arsenic trioxide (As 2 O 3 )-induced cardiac fibrosis and explore underlying mechanisms. Cardiac dysfunction observed rats after exposure As for 15 days using echocardiography deposition collagen detected by Masson’s trichrome staining electron microscope. indicated loss cell markers (VE-cadherin...
Excess activation of cardiac fibroblasts inevitably induces fibrosis. Emodin has been used as a natural medicine against several chronic diseases. The objective this study is to determine the effects emodin on fibrosis and underlying molecular mechanisms. Intragastric administration markedly decreased left ventricular wall thickness in mouse model pathological hypertrophy with excess induced by transaortic constriction (TAC) suppressed angiotensin II (AngII). upregulated expression...
The availability of simple, accurate, and affordable cuffless blood pressure (BP) devices has the potential to greatly increase compliance with measurement recommendations utilization BP measurements for telemonitoring. aim this study is evaluate correlation between findings from routine using a conventional sphygmomanometer results portable ECG monitor combined photoplethysmography (PPG) pulse wave registration in patients arterial hypertension. Methods: included 500 aged 32–88 years (mean...
Aim. To evaluate the effect of inflammatory bowel disease (IBD) on risk atherosclerosis in patients without known cardiovascular disease. Materials and methods. The study included 115 divided into three groups: 37 with Crohn's (CD), 44 ulcerative colitis (UC), 34 control group IBD other factors. Doppler ultrasound brachiocephalic arteries sphygmometry were used for diagnosis. main indicators thickness intima-media complex (TIMC) vascular stiffness, measured by cardio-ankle index (CAVI)...
Cardiovascular disease (CVD) and associated sequalae remain the leading cause of disability worldwide. Ischemic heart (IHD) failure are most common etiologies morbidity mortality This is due to poor diagnostic management methods for IHD. Early detection related risk factors through modern strategies underestimated requires further research. To interpret data from published literature on volatile organic compounds (VOC), including all used analyze exhaled breath in patients with IHD failure....
Background: Acute heart failure (AHF) is one of the leading causes admissions to emergency department (ED). There a need develop an easy-to-use score that can be used in ED risk-stratify patients with AHF and hospitalization decisions regarding cardiac wards or intensive care units (ICUs). Methods: A retrospective observational study was conducted at city hospital. The data from presentation were collected. combined primary endpoint included death any cause during transfer unit (ICU) for...
The aim of this study was to evaluate efficacy and applicability the “intermittent hypoxic-hyperoxic exposures at rest” (IHHE) protocol as an adjuvant method for metabolic syndrome (MS) cardiometabolic components. A prospective, single-center, randomized controlled clinical conducted on 65 patients with MS subject optimal pharmacotherapy, who were randomly allocated IHHE or control (CON) groups. group completed a 3-week, 5 days/week program IHHE, each treatment session lasting 45 min. CON...
Abstract Background The development of heart ageing is the main cause chronic disability, disease and death in elderly. Ample evidence has established a pivotal role for significantly reduced mitophagy heart. However, underlying mechanisms deficiency are little known. present study aimed to explore lncRNA LOC105378097 (Senescence‐Mitophagy Associated LncRNA, lncR‐SMAL) actions on setting ageing. Methods expression lncR‐SMAL was measured serum from different ages human mice through...
Non-coding RNAs reflect many biological processes in the human body, including athero-sclerosis. In a cardiology outpatient department cohort (N = 83), we aimed to compare levels of circulating microRNAs groups with vulnerable plaques 22), stable 23) and plaque-free 17) depending on coronary computed tomography angiography evaluate associations microRNA calculated cardiovascular risks (CVR), based SCORE2 (+OP), ACC/AHA, ATP-III MESA scales. Coronary was performed 640-slice scanner. Relative...
Abstract Heart aging is a prevalent cause of cardiovascular diseases among the elderly. NAD + depletion hallmark feature heart, however, molecular mechanisms that affect remain unclear. In this study, we identified microRNA‐203 (miR‐203) as senescence‐associated microRNA regulates homeostasis. We found blood miR‐203 level negatively correlated with human age and its expression significantly decreased in hearts aged mice senescent cardiomyocytes. Transgenic overexpressed (TgN (miR‐203))...
Adequate personalized numerical simulation of hemodynamic indices in coronary arteries requires accurate identification the key parameters. Elastic properties vessels produce a significant effect on accuracy simulations. Direct measurements elasticity are not available general clinic. Pulse wave velocity (AoPWV) aorta correlates with aortic and elasticity. In this work, we present neural network approach for estimating AoPWV. Because limited number clinical cases, used synthetic AoPWV...
Anti-cancer treatment can be fraught with cardiovascular complications, which is the most common cause of death among oncological survivors. Without appropriate cardiomonitoring during anti-cancer treatment, it becomes challenging to detect early signs complications. In order achieve higher survival rates, necessary monitor patients outpatiently after administration. this regard, we aim evaluate efficacy single-lead ECG remote monitoring cardiotoxicity in cancer minimal diseases first cycle...
Non-small cell lung carcinoma (NSCLC) is the major cause of cancer-associated mortality. Identification rearrangements in anaplastic lymphoma kinase (ALK) gene an effective instrument for more targeted therapy NSCLC using ALK inhibitors dramatically raising progression-free survival ALK-mutated group patients. However, tumors frequently develop resistance to inhibitors. We describe here a case 48 y.o. male patient with ALK-positive who was clinically managed 6.5 years from diagnosis. The...
In this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study effects arrhythmias on blood flow (CBF). Hydrodynamical models are rarely used arrhythmias’ CBF. Our accounts for action potential duration, which updates length systole depending heart rate. It also includes dependency stroke volume rate, is based clinical data. We apply new methodology computational evaluation CBF during interventricular asynchrony due cardiac pacing some types...
Circulating serum miRNA are increasingly used as biomarkers and potential treatment targets in several clinical scenarios, including cardiovascular diseases. However, the current data on circulating thoracic aorta aneurism (TAA) patients inconclusive. The aim of present study is to compare levels with degenerative TAA, coronary artery disease (CAD), controls for special profile identification. We have identified candidates role new biomarkers: miR-143-3p, miR-181-5p, miR-126-3p, miR-126-5p,...
Objectives: Blood-based tests have been shown to be an effective strategy for colorectal cancer (CRC) detection in screening programs. This study was aimed test the performance of 20 blood markers including tumor antigens, inflammatory and apolipoproteins as well their combinations. Methods: In total 203 healthy volunteers 102 patients with CRC were enrolled into study. Differences between subjects evaluated using Wilcoxon rank-sum test. Several multivariate classification algorithms...
Abstract In the present paper we construct model of coronary flow which utilizes patient’s CT data on both large CA and perfusion. We reconstruct vessels based extrude possibly invisible from branches left artery so that every terminal point supply standardized zone myocardium. apply a previously developed validated 1D haemodynamics. Utilizing patient-specific CTP for modifying outflow resistance at rest under stress conditions is major novelty work. From our results it follows acceptable...
In this work we propose a method for analysis of postsurgical haemodynamics after femoral artery treatment occlusive vascular disease. Patient specific reconstruction algorithm 1D core network based on MRI data is proposed as tool such analysis. Along with presurgical ultrasound fitting it provides effective personalizing predictive that validated clinical observations.
Until recently, Russia did not utilize noninvasive fractional flow reserve (FFR) assessment. We developed an automated algorithm for assessment of FFR based on a one-dimensional (1D) mathematical modeling. The research aims to evaluate the diagnostic accuracy this algorithm. study enrolled 80 patients: 16 them underwent 64-slice computed tomography - included retrospectively, 64 prospectively, with 640-slice CT scan. Specialists processed images and evaluated FFR. Ischemia was confirmed if <...
Background Cardiopulmonary exercise testing (CPET) has shown to be useful for preoperative risk stratification in various types of intra-abdominal and thoracic surgery. However, data about the predictive value CPET cardiovascular outcome after gastric or oesophageal cancer surgery are inconclusive. The aim this study was evaluate prognostic parameters prediction complications patients with type Methods This is a prospective single-centre interventional cohort including 200 consecutive who...
Aims: To investigate the potential of a signal processed by smartphone-case based on single lead electrocardiogram (ECG) for left ventricular diastolic dysfunction (LVDD) determination as screening method. Methods and Results: We included 446 subjects sample learning 259 patients test aged 39 to 74 years testing with 2D-echocardiography, tissue Doppler imaging ECG using monitor assessment LVDD. Spectral analysis signals (spECG) has been used in combination advanced processing artificial...