A5008959614- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- Neurology and Historical Studies
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Heart Rate Variability and Autonomic Control
- Neural dynamics and brain function
- Cardiac Valve Diseases and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Myasthenia Gravis and Thymoma
- Blood Coagulation and Thrombosis Mechanisms
- Neurological Disorders and Treatments
- Biomarkers in Disease Mechanisms
- Neurological Complications and Syndromes
- Polyomavirus and related diseases
- Systemic Sclerosis and Related Diseases
- Neurosurgical Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
University of Bern
2010-2022
Brescia University
2021
University of Brescia
2021
University Hospital of Bern
2010-2020
University Hospital of Zurich
2010-2019
University Hospital of Basel
2019
University of Basel
2019
Luzerner Kantonsspital
2019
Goethe University Frankfurt
2019
Kantonsspital Aarau
2019
Randomized controlled trials have shown that bridging endovascular therapy (EVT) after intravenous thrombolysis (IVT) improves outcome in patients with stroke large-artery anterior circulation compared IVT alone. It remains unknown whether adds any benefit to EVT these patients. The aim of this study was assess recanalization rates and thrombus dislocation before initiation receiving therapy.All the Bernese registry (2008-2015) whom considered were included analysis. Relevant EVT, increase...
<h3>Objectives</h3> To derive and externally validate a copeptin-based parsimonious score to predict unfavorable outcome 3 months after an acute ischemic stroke (AIS). <h3>Methods</h3> The derivation cohort consisted of patients with AIS enrolled prospectively at the University Hospital Basel, Switzerland. validation was Bern Switzerland, as well Frankfurt a.M., Germany. components were copeptin levels, age, NIH Stroke Scale, recanalization therapy (CoRisk score). Copeptin levels measured in...
<h3>BACKGROUND AND PURPOSE:</h3> General anesthesia during endovascular treatment of acute ischemic stroke may have an adverse effect on outcome compared with conscious sedation. The aim this study was to examine the impact type patients treated Solitaire stent retriever, accounting for confounding factors. <h3>MATERIALS METHODS:</h3> Four-hundred one consecutive anterior circulation a retriever were included in prospective analysis. Outcome assessed after 3 months by modified Rankin Scale....
Introduction In patients with stroke attributable to cervical artery dissection, we compared endovascular therapy intravenous thrombolysis regarding three-month outcome, recanalisation and complications. Materials methods a multicentre thrombolysis/endovascular therapy-register-based cohort study, all consecutive dissection intracranial occlusion treated within 6 h were eligible for analysis. Endovascular (with or without prior thrombolysis) (i) excellent outcome (modified Rankin Scale score...
To assess putative risk factors and outcome of multiple early recurrent cervical artery dissection (CeAD). We combined data from 2 multicenter cohorts compared patients with CeAD at initial diagnosis, within 3 to 6 months, single nonrecurrent CeAD. Putative factors, clinical characteristics, functional outcome, ischemic events were assessed. Of 1,958 (mean ± SD age 44.3 10 years, 43.9% women), 1,588 (81.1%) had CeAD, 340 (17.4%) 30 (1.5%) presented admission Patients or did not significantly...
Background Recent studies suggest a paradoxical association between smoking status and clinical outcome after intravenous thrombolysis (IVT). Little is known about relationship stroke endovascular treatment (EVT). Methods We analyzed data of all patients treated with EVT at the tertiary centre Berne January 2005 December 2015. Using uni- multivariate modeling, we assessed whether was independently associated excellent (modified Rankin Scale (mRS) 0–1) mortality 3 months. In addition, also...
Background and Purpose— The impact of smoking on prognosis after stroke is controversial. We aimed to assess the relationship between status outcome intravenous thrombolysis in a large cohort study by adjusting for potential confounders incorporating recanalization rates. Methods— In prospective observational multicenter study, we analyzed baseline data consecutive patients with acute ischemic treated thrombolysis. Using uni- multivariable modeling, assessed whether was associated favorable...
In patients with disorders of consciousness (DOC), properties functional brain networks at rest are informative the degree impairment and long-term outcome. Here we investigate whether connectivity differences between favorable unfavorable outcome already present within 24 h coma onset. We prospectively recorded 63-channel electroencephalography (EEG) during first day after cardiac arrest. analyzed 98 adults, whom 57 survived beyond unresponsive wakefulness. Functional was estimated by...
Abstract Objective Prominent research in patients with disorders of consciousness investigated the electrophysiological correlates auditory deviance detection as a marker recovery. Here, we extend previous studies by investigating whether somatosensory provides an added value for outcome prediction postanoxic comatose patients. Methods Electroencephalography responses to frequent and rare stimuli were obtained from 66 on first second day after coma onset. Results Multivariate decoding...
Network oscillations in the brain are routinely recorded clinic and research lab. Here we outline a new paradigm which network serve as treatment targets for noninvasive stimulation. We show how transcranial alternating current stimulation (tACS) can be used to modulate that impaired disorders of central nervous system (CNS). Using rational design, structured process target identification, engagement, validation deployed develop effective paradigms neurological psychiatric illnesses....
Abstract Background and Purpose To determine the prognostic value for ischemic stroke or transitory attack (TIA) of plaque surface echogenicity alone combined to degree stenosis in a Swiss multicenter cohort Methods Patients with ≥60% asymptomatic ≥50% symptomatic carotid were included. Grey‐scale based colour mapping was obtained whole its defined as regions between lumen respectively 0‐0.5, 0–1, 0–1.5, 0–2 mm outer border plaque. Red, yellow green represented low, intermediate high...
Some authors use FLAIR imaging to select patients for stroke treatment. However, the effect of hyperintensity on images outcome and bleeding has been addressed in only few studies with conflicting results.466 anterior circulation strokes were included this study. They all examined MRI before intravenous or endovascular Baseline data 3 months recorded prospectively. Focal T2 hyperintensities within ischemic lesion evaluated by two raters, PROACT II classification was applied assess...
Connecting with junior colleagues across the three linguistic regions of Switzerland, knowing essentials Swiss neurology curriculum, conducting research, considering a fellowship abroad, preparing neurological activity in private practice - all these topics are vital interest for young neurologists. However, keeping up such essential aspects training usually turns out quite demanding residents as individuals. Junior neurologists’ associations help to deal issues. In 2014, group enthusiastic...
Purpose: There is much controversy about the prevalence of cardiac involvement in patients with rheumatic disorders.This importance, since consequences range from different treatment regimes to adverse outcomes.Consequently, our primary aim was evaluate forms disorders by CMR.Methods: 297 underwent CMR.Cardiac defined presence late gadolinium enhancement (LGE).Patients a history myocardial infarction and/ or prior revascularization procedure were excluded.Patients further divided into 5...
Interdisciplinary cooperation and interaction have grown extremely important will soon become indispensable in clinical neuroscience. The constantly increasing degree of specialization may further compartmentalize the different neuroscience disciplines, potentially altering a unified identity field. In 2016, Swiss Federation Clinical Neuro-Societies (SFCNS) encouraged creation Young Neuroscientists (YouCliN) Network bringing together juniors from all specialties united SFCNS – that is,...
Background: Quantitative computed tomography (QCT) extracts features from high-resolution CT scans and quantifies lung parenchymal vascular abnormalities which may not be discernable by qualitative review. The threshold values of individual measured QCT methods associate with mortality in systemic sclerosis (SSc) are currently unknown. Objectives: To determine whether measures, specifically pulmonary related structures (PVRS), can predict SSc to the optimal quantitative thresholds for those...