A5042524318- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Electrolyte and hormonal disorders
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Mechanical Circulatory Support Devices
- Parathyroid Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- IL-33, ST2, and ILC Pathways
- Muscle activation and electromyography studies
- Hemodynamic Monitoring and Therapy
- Cardiac Valve Diseases and Treatments
- Acute Kidney Injury Research
- Tracheal and airway disorders
University of Basel
2010-2024
Solothurner Spitäler
2016-2024
Kantonsschule Olten
2019-2023
University Hospital of Basel
2009-2023
Heinrich Heine University Düsseldorf
2023
Düsseldorf University Hospital
2023
Heidelberg University
2016-2021
IRCCS Materno Infantile Burlo Garofolo
2016
NIHR Leicester Cardiovascular Biomedical Research Unit
2016
National Institute for Health Research
2016
Myeloperoxidase (MPO) is a biomarker of inflammation and oxidative stress produced by neutrophils, monocytes, endothelial cells. Concentrations MPO predict mortality in patients with chronic heart failure. This study sought to investigate the diagnostic accuracy prognostic value acute failure (AHF).We prospectively enrolled 667 presenting emergency department dyspnea observed them for 1 year. B-type natriuretic peptide (BNP) were measured at presentation. Two independent cardiologists...
Monitoring treatment efficacy and assessing outcome by serial measurements of natriuretic peptides in acute decompensated heart failure (ADHF) patients may help to improve outcome.This was a prospective multi-center study 171 consecutive (mean age 80 73-85 years) presenting the emergency department with ADHF. Measurement BNP NT-proBNP performed at presentation, 24 hours, 48 hours discharge. The primary endpoint one-year all-cause mortality; secondary endpoints were 30-days mortality (HF)...
Long axis strain (LAS) has been shown to be a fast assessable parameter representing global left ventricular (LV) longitudinal function in cardiovascular magnetic resonance (CMR). However, the prognostic value of LAS cardiomyopathies with reduced ejection fraction (LVEF) not evaluated yet. In 146 subjects non-ischemic dilated cardiomyopathy (NIDCM, LVEF ≤45 %) was assessed retrospectively from standard non-contrast SSFP cine sequences by measuring distance between epicardial border apex and...
The aim of our study was to investigate the diagnostic and prognostic value a sensitive cardiac troponin I (s-cTnI) assay in patients with acute heart failure (AHF).Sensitive measured 667 consecutive at presentation emergency department dyspnoea. Three s-cTnI strata were predefined: below limit detection (<0.01 μg L(-1) , undetectable), detectable but still within normal range (0.01-0.027 ) increased (≥0.028 ≥99th percentile). final diagnosis adjudicated by two independent cardiologists...
The identification of patients at highest risk for adverse outcome who are presenting with acute dyspnea to the emergency department remains a challenge. This study investigates prognostic value Copeptin, C-terminal part vasopressin prohormone alone and combined N-terminal pro B-type natriuretic peptide (NT-proBNP) in dyspnea.We conducted prospective, observational cohort university hospital enrolled 287 dyspnea.Copeptin levels were elevated non-survivors (n = 29) compared survivors 30 days...
Abstract Introduction The accurate prediction of acute kidney injury (AKI) in patients with heart failure (AHF) is an unmet clinical need. Neutrophil gelatinase-associated lipocalin (NGAL) a novel sensitive and specific marker AKI. Methods A total 207 consecutive presenting to the emergency department AHF were enrolled. Plasma NGAL was measured blinded fashion at presentation serially thereafter. potential plasma levels predict AKI assessed as primary endpoint. We defined according Network...
Purpose To assess the utility of established functional markers versus two additional derived from standard cardiovascular magnetic resonance (MR) images for their incremental diagnostic and prognostic information in patients with nonischemic dilated cardiomyopathy (NIDCM). Materials Methods Approval was obtained local ethics committee. MR 453 NIDCM 150 healthy control subjects were included between 2005 2013 analyzed retrospectively. Myocardial contraction fraction (MCF) calculated by...
Left ventricular hypertrophy (LVH) has strong prognostic implications and is associated with heart failure. Recently, myocardial contraction fraction (MCF) was identified as a useful marker for specifically identifying cardiac amyloidosis (CA). The purpose of this study to evaluate the diagnostic accuracy MCF discrimination different forms LVH. We analysed cardiovascular magnetic resonance (CMR) scans patients CA (n = 132), hypertrophic cardiomyopathy (HCM, n 60), hypertensive disease (HHD,...
Data on the prognostic value of left ventricular (LV) morphological and functional parameters including LV rotation in patients with dilated cardiomyopathy (DCM) using cardiovascular magnetic resonance (CMR) are currently scarce. In this study, we assessed global longitudinal strain (GLS), circumferential (GCS), radial (GRS) torsion CMR feature tracking (FT).
The differentiated assessment of functional parameters besides morphological changes is essential for the evaluation prognosis in systemic immunoglobulin light chain (AL) amyloidosis.
Abstract. Socrates T, deFilippi C, Reichlin Twerenbold R, Breidhardt Noveanu M, Potocki Reiter Arenja N, Heinisch Meissner J, Jaeger Christenson Mueller C. (Department of Internal Medicine, University Hospital Basel, Switzerland; Maryland, School Baltimore, MD, USA). Interleukin family member ST2 and mortality in acute dyspnoea. J Intern Med 2010; 268 : 493–500. Objectives. The study objective was to investigate the prognostic utility patient‐specific characteristics (suppression...
Abstract. Burri E, Hochholzer K, Arenja N, Martin‐Braschler H, Kaestner L, Gekeler Hatziisaak T, Büttiker M, Fräulin A, Potocki Breidthardt Reichlin Socrates Twerenbold R, Mueller C (University Hospital Basel, Basel; University Hospital, Switzerland). B‐type natriuretic peptide in the evaluation and management of dyspnoea primary care. J Intern Med 2012; 272: 504–513. Objectives. The rapid accurate diagnosis heart failure care is a major unmet clinical need. We evaluated additional use (BNP)...
The early and noninvasive differentiation of ischemic nonischemic acute heart failure (AHF) in the emergency department (ED) is an unmet clinical need.We quantified cardiac hemodynamic stress using B-type natriuretic peptide (BNP) cardiomyocyte damage 2 different troponin assays 718 consecutive patients presenting to ED with AHF (derivation cohort). diagnosis was adjudicated all information, including coronary angiography. Findings were validated a second independent multicenter cohort (326...
BACKGROUND: Delayed recognition of sepsis and inappropriate initial antibiotic therapy are associated with increased mortality morbidity. The early detection the causative organism in is an unmet clinical need. A novel multiplex real-time polymerase chain reaction (MRT-PCR) (SeptiFast®) technique may provide microbiological diagnosis within six hours.