A5085779970- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Surgical Simulation and Training
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Neurosurgical Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic and Acetabular Injuries
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Dysraphism and Malformations
- Global Health and Surgery
- Cardiovascular Health and Disease Prevention
- Musculoskeletal pain and rehabilitation
- Sarcoma Diagnosis and Treatment
- Hospital Admissions and Outcomes
- Adrenal and Paraganglionic Tumors
- Oral and Maxillofacial Pathology
- Cervical and Thoracic Myelopathy
Ospedale regionale di Lugano
2014-2024
Ente Ospedaliero Cantonale
2015-2023
Laboratory for Biomedical Neurosciences
2018-2022
Klinikum rechts der Isar
2013-2016
Western General Hospital
2016
University Medical Center of the Johannes Gutenberg University Mainz
2016
Johannes Gutenberg University Mainz
2016
University Hospital of Geneva
2016
Military University Hospital Prague
2016
Charles University
2016
Background and Purpose— To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage to estimate their impact. Methods— Retrospective analysis prospective data from a nationwide multicenter registry on all cases admitted tertiary neurosurgical department Switzerland (Swiss SOS [Swiss Study Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). Both clinical radiological independent were identified, effect size was determined by calculating adjusted odds...
OBJECT In ventriculoperitoneal (VP) shunt surgery, laparoscopic assistance can be used for placement of the peritoneal catheter. Until now, efficacy has been investigated only in retrospective and nonrandomized prospective studies, which have reported decreased distal dysfunction rates patients undergoing laparascopic compared with mini-laparotomy cohorts. this randomized controlled trial authors failure who underwent surgery catheter traditional mini-laparotomy. METHODS One hundred twenty...
To describe a new technique to obtain minimally invasive but efficient vertebral body (VB) reconstruction, augmentation, and stabilization in severe osteoporotic neoplastic fractures, combining two pre-existing procedures. The implant of stents (VBS) is followed by insertion percutaneous, fenestrated, cement-augmented pedicular screws that act as anchors the posterior elements for cement/stent complex. reduce risk stent mobilization non-intact VB cortical shell bridge middle column...
Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa , displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells influence of curcumin production hypoxia inducible factor 1α (HIF1A) vascular endothelial growth A (VEGFA), two key components involved neovascularisation through angiogenesis. dose-dependently inhibited basal VEGFA secretion corticotroph AtT20 mouse...
Burst fractures are characterized by middle column disruption and may feature posterior wall retropulsion. Indications for treatment remain controversial. Recently introduced vertebral augmentation techniques using intravertebral distraction devices, such as body stents SpineJack, could be effective in fracture reduction fixation might obtain central canal clearance through ligamentotaxis. This study assesses the results of armed kyphoplasty or SpineJack traumatic, osteoporotic, neoplastic...
Abstract The world currently faces the novel severe acute respiratory syndrome coronavirus 2 pandemic. Little is known about effects of a pandemic on non-elective neurosurgical practices, which have continued under modified conditions to reduce spread COVID-19. This knowledge might be critical for ongoing second wave and potential restrictions health care. We aimed determine incidence 30-day mortality rate various procedures during COVID-19 A retrospective, multi-centre observational cohort...
The risk of recurrence cerebrovascular events within the first 72 hours admission in patients hospitalized with symptomatic carotid artery (CA) stenoses and risks benefits emergency CA intervention after onset symptoms are not well known. Therefore, authors aimed to assess (1) ipsilateral rate admission, period from 7 days, days presenting nondisabling stroke, transient ischemic attack (TIA), or amaurosis fugax (AF), an stenosis 50% more, (2) stroke interventions 48 versus performed...
Chronic subdural hematoma (cSDH) is a disease affecting mainly elderly individuals. The reported incidence ranges from 2.0/100,000 to 58 per 100,000 person-years when only considering patients who are over 70 years old, with an overall of 8.2-14.0 persons. Due estimated doubling the population above 65 old between 2000 and 2030, cSDH will become even more significant concern. To gain overview hospital admission rates, treatment, outcome, we performed this multicenter national cohort study...
The treatment of complex cerebrovascular or skull base pathological conditions necessitates a microsurgical blood flow preservation augmentative revascularization procedure as either an adjunctive safety measure definitive treatment. brain is susceptible to ischemia, and procedure-related risks can be minimized by the reduction occlusion time use nonocclusive technique. authors therefore analyzed feasibility automatic device (C-Port xA, Cardica) designed for constructing end-to-side...
Carotid endarterectomy (CEA) reduces the risk of stroke in patients with symptomatic (>50%) and asymptomatic (>60%) carotid artery stenosis. Here we report midterm results a microsurgical non-patch technique compare these findings to those literature.From 1998 2009 treated 586 consecutive CEA. CEA was performed, under general anesthesia, surgical microscope using technique. Somatosensory evoked potential transcranial Doppler were continuously monitored. Cross-clamping performed EEG burst...
Transthyretin (ATTR) amyloidosis is often diagnosed in an advanced stage, when irreversible cardiac damage has occurred. Lumbar spinal stenosis (LSS) may precede ATTR by many years, offering the opportunity to detect already at time of LSS surgery. We prospectively assessed prevalence ligamentum flavum tissue biopsy patients aged >50 years undergoing surgery for LSS.Ligamentum thickness was pre-operatively on axial T2 magnetic resonance imaging (MRI) slices. Tissue samples from were screened...
Altered biomechanics or bone fragility both contribute to spine instrumentation failure. Although revision surgery is frequently required, minimally invasive alternatives may be feasible. We report the largest to-date series of percutaneous fluoroscopically guided vertebral cement augmentation procedures address feasibility, safety, results and a variety spinal failure conditions.A consecutive 31 in 29 patients were performed screw loosening (42 screws), cage subsidence (7 cages), fracture...
Introduction Efficient neurosurgical training is of paramount importance to provide continuing high-quality medical care patients. In this era law-enforced working hour restrictions, however, maintaining can be a challenge and requires some restructuring. We evaluated the current status resident in Germany. Methods An electronic survey was sent European trainees between June 2014 March 2015. The responses German were compared with those from other countries. Logistic regression analysis...
Encephaloceles are herniations of brain parenchyma through congenital or acquired osseous-dural defects the skull base cranial vault. Different types symptoms, due to CSF fistulas, meningitis, seizures, often associated with this condition. The authors present a rare case spontaneous right frontal parasagittal encephalocele in 70-year-old man who was experiencing spastic progressive paresis his left lower limb. Results routine electrophysiological workup (motor evoked potentials,...