Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa , displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells influence of curcumin production hypoxia inducible factor 1α (HIF1A) vascular endothelial growth A (VEGFA), two key components involved neovascularisation through angiogenesis. dose-dependently inhibited basal VEGFA secretion corticotroph AtT20 mouse...

Purpose The occurrence of thrombus migration (TM) in middle cerebral arteries (MCAs) prior to mechanical thrombectomy (MT) patients suffering from acute ischemic strokes is a crucial aspect as TM associated with lower rates complete reperfusion and worse clinical outcomes. In this study, we sought clarify whether histological composition influences TM. Methods We included 64 MCA occlusions who had undergone MT. 11 the cases (17.2%) identified interventions. extracted clots were collected...

OBJECTIVE Moyamoya angiopathy (MMA) is characterized by the plasticity to develop endogenous collateral blood vessels compensate for progressive steno-occlusion of proximal intracranial arteries. Bypass surgery has been anecdotally reported induce regression these vessels, but a detailed analysis their natural history lacking. Here, authors characterize collaterals after bypass surgery. METHODS A single-center retrospective medical records 81 predominantly Caucasian MMA patients (121...

Abstract Overactivation of the cAMP signal transduction pathway plays a central role in pathogenesis endocrine tumors. Genetic aberrations leading to increased intracellular or directly affecting PKA subunit expression have been identified inherited and sporadic tumors, but are rare indicating presence nongenomic pathological activation. In present study, we examined impact hypoxia on activation using human growth hormone (GH)-secreting pituitary tumors as model an disease displaying...

Aggressive pituitary tumors are rare but difficult to manage, as there is no effective chemotherapy restrict their growth and cause shrinkage. Within these tumors, growth-promoting cascades, like the PI3K/mTOR pathway, appear be activated. We tested efficacy of two inhibitors this NVP-BKM120 (Buparlisib; pan-PI3K) NVP-BEZ235 (dual PI3K/mTOR), both in vitro on immortalized tumor cells (GH3) primary cell cultures human vivo a rat model prolactin (PRL) (SMtTW3). In vitro, had potent apoptotic...

Objective: Current literature debates the role of newly developed three-dimensional (3D) Exoscopes in daily routine neurosurgical practice. So far, only a small number cadaver lab studies or case reports have examined novel Aesculap Aeos Three-Dimensional Robotic Digital Microscope. This study aims to evaluate grade satisfaction and intraoperative handling this system neurosurgery. Methods: Nineteen procedures (12 cranial, 6 spinal 1 peripheral nerve) performed over 9 weeks using were...

Despite current clinical guidelines recommending suboccipital decompressive craniectomy (SDC) in cerebellar infarction when patients present with neurological deterioration, the precise definition of deterioration remains unclear and accurate timing SDC can be challenging. The study aimed at characterizing whether outcomes predicted by GCS score immediately prior to higher scores are associated better outcomes.In a single-center, retrospective analysis 51 treated for space-occupying...

// Yonghe Wu 1, 6 , Lucas Tedesco 2 Kristin Lucia 1 Anna M. Schlitter 3 Jose Monteserin Garcia Irene Esposito 3, 7 Christoph J. Auernhammer 4 Marily Theodoropoulou Eduardo Arzt 2, 5 Ulrich Renner Günter K. Stalla Department of Clinical Neuroendocrinology, Max Planck Institute Psychiatry, Munich, Germany Instituto de Investigación en Biomedicina Buenos Aires (IBioBA)-CONICET-Partner the Society, Aires, Argentina Pathology, Technical University Internal Medicine II, University-Hospital Campus...

Abstract Following elective craniotomy, patients routinely receive 24-h monitoring in an intensive care unit (ICU). However, the benefit of and treatment these is discussed controversially. This study aimed to evaluate complication profile a “No ICU – Unless” strategy compare this with standardized management post-craniotomy ICU. Two postoperative strategies were compared matched-pair analysis: The first cohort included who managed normal ward postoperatively (“No group). second contained...

Vascular guidance is critical in developmental vasculogenesis and pathological angiogenesis. Brain tumors are strongly vascularized, antiangiogenic therapy was anticipated to exhibit a strong anti-tumor effect this tumor type. However, vascular endothelial growth factor A (VEGFA) specific inhibition had no significant impact clinical practice of gliomas. More research needed understand the failure therapeutic approach. EphrinB2 has been found directly interact with receptor 2 (VEGFR2)...

Despite intensive research, glioblastoma remains almost invariably fatal. Various promising drugs targeting specific aspects of glioma biology, in addition to or as an alternative antiproliferative chemotherapy, were not successful larger clinical trials. Further insights into the biology and mechanisms behind evasive-adaptive response targeted therapies is needed help identify new therapeutic targets, prognostics, predictive biomarkers. As a modulator canonically oncogenic Rho-GTPase...

In adult scoliosis, dorsal instrumentation and fusion can provide significant improvement of pain disability scores (Owestry Index); however, complication rates up to 39% have been reported. As such, recent attempts made at expanding the surgical spectrum include less invasive techniques in patients such as neuromodulation, specifically spinal cord stimulation (SCS). We therefore aimed evaluate its use a larger cohort scoliosis form pilot study.We analyzed prospectively collected data from...

Quality Assurance and Education are 2 areas of the Cancer Registry that go hand in hand. High-quality data can only be maintained through routine surveillance quality coupled with tailored continuing education certified tumor registrars (CTRs). However, magnitude information a CTR is required to know, rapid frequency which standards change, growing demands on time CTRs roadblocks maintaining Registry. Here we describe robust approach assurance high-volume hospital-based Registry, leveraging...

Moyamoya angiopathy (MMA) can be treated using direct, indirect, or combined revascularization procedures. We perform the STA-MCA bypass and minimally invasive encephalodurosynangiosis (MIS-EDS). Due to lack of systematic analyses date it remains unclear whether which extent this limited EDS serves as a growth source for extracerebral blood vessels into brain. The objective current study is characterize angiographic filling MIS-EDS development over time determine possible predictors in adult...

A central component of injury development after acute subdural hematoma (ASDH) is the increased intracranial pressure and consecutive mechanical reduction cerebral blood flow (CBF). However, role different constituents in ASDH as additional lesioning factors remains unclear. This study examines influence components on neuroinflammation, blood-brain barrier (BBB) breakdown, functional deficits a rat model ASDH. We infused corpuscular (whole blood, whole lysate, red cell blood) plasmatic...

Background: Anterior cervical discectomy and fusion (ACDF) is a commonly implemented surgical intervention for variety of pathologies affecting the spine. The current literature daily practice reveal variations on patient head positioning this procedure with both rigid fixations in Mayfield skull clamp as well use padded headrest being used. In study, we therefore examine whether patients undergoing surgery using versus differ regard to adverse events, parameters clinical outcome.

Patients with Moyamoya Angiopathy (MMA) display structurally altered vessels decreased cerebral autoregulatory capacity, so aggressive lowering of systemic hypertension may aggravate ischemic symptoms, whereas uncontrolled promote hemorrhage. This study provides an in-depth analysis the role in adult MMA patients including long-term clinical and radiological development. In this single-center retrospective 137 206 surgically treated hemispheres angiographic images, clinical/operative data...

Objectives: Moyamoya vasculopathy (MMV) is a rare stenoocclusive cerebrovascular disease associated with increased risk of ischemic and hemorrhagic stroke, which can be treated using surgical revascularization techniques. Despite well-established neurosurgical procedures performed in experienced centers, bypass failure neurological symptoms occur. The current study therefore aims at characterizing the cases repeat single center. Methods: A single-center retrospective analysis all patients...