A5018374017- Sepsis Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Multiple Sclerosis Research Studies
- Radiation Dose and Imaging
- Clinical Reasoning and Diagnostic Skills
- Glioma Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Systemic Lupus Erythematosus Research
- Cancer Diagnosis and Treatment
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Hematological disorders and diagnostics
- Cardiac Arrhythmias and Treatments
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Optimal Experimental Design Methods
- Facial Trauma and Fracture Management
- Moyamoya disease diagnosis and treatment
- Infant Development and Preterm Care
- Peripheral Neuropathies and Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
Humboldt-Universität zu Berlin
2021-2025
Charité - Universitätsmedizin Berlin
2020-2025
Freie Universität Berlin
2021-2025
Zimmer Biomet (Germany)
2020-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2024
This study aims to assess the effectiveness of digital multidisciplinary conferences (MDCs) in preventing imaging-related quality management (QM) events during coronavirus-disease-19 (COVID-19) pandemic. COVID-19 challenged interdisciplinary exchange and QM measures for patient safety. Regular MDCs between radiologists intensive care unit (ICU) physicians, introduced our hospital 2018, enable re-evaluation imaging examinations bilateral feedback. MDC protocols from 2020 2021 were analysed...
This prospective study assesses the acceptance and usefulness of augmented 360° virtual reality (VR) videos for early student education preparation in field neurosurgery. Thirty-five third-year medical students participated. Augmented VR depicting three neurosurgical procedures (lumbar discectomy, brain metastasis resection, clipping an aneurysm) were presented during elective seminars. Multiple questionnaires employed to evaluate conceptual technical aspects videos. The analysis utilized...
Abstract Objectives To survey physicians’ views on the risks and benefits of computed tomography (CT) in management septic patients indications for contraindications to contrast media use searching foci. Methods A web-based questionnaire was administered physicians at a large European university medical center January 2022. total 371 questionnaires met inclusion criteria were analyzed with work experience, workplace, specialty as independent variables. Chi-square tests used exploratory...
Post-COVID syndrome (PCS) has emerged as a significant health concern with persisting symptoms. A subset of PCS patients develops severe myalgic encephalomyelitis/chronic fatigue (pcME/CFS). Dysregulated autoantibodies (AABs) have been implicated in PCS, contributing to immune dysregulation, impairment autonomous nerve and vascular function. As recently shown autoimmune diseases, IgG fractions translate disease-specific pathways into various cells. Therefore, we asked whether from could be...
Objective: To assess the effectiveness of Peerspectives course on editor-judged quality peer review Design: Single arm, pre-post interventional study Setting: is a training developed for doctoral students at Charite - Universitatsmedizin Berlin, Germany Participants: Doctoral in health research domains who enrolled between October 2020 and August 2022 consented to participate (N = 80). Intervention: A semester-long (approx. 18 weeks) providing about structure, purpose, conduct editing...
Different parameters have been identified in patients with oral squamous cell carcinomas (OSCC) that a serious impact on survival, including residual tumour and extracapsular spread. Moreover, other factors, the lymph node ratio (LNR) yield (LNY), suggested as prognostic markers.This retrospective study included diagnosed OSCC cervical metastases during years 2010-2020. Patients' records were evaluated regarding status, final therapy regime, recurrence, time to death, association...
Tumor recurrence is the main challenge in glioblastoma (GBM) treatment. Gold standard therapy temozolomide (TMZ) known to induce upregulation of IL8/CXCL2/CXCR2 signaling that promotes tumor progression and angiogenesis. Our aim was verify alterations on this pathway human GBM investigate impact TMZ particular. Furthermore, a combi-therapy CXCR2 antagonization established assess efficacy tolerability. First, we analyzed 76 matched primary recurrent samples with regard various histological...
Orbital compartment syndrome is a sight-threatening emergency caused by rising pressure inside the orbit. It usually diagnosed clinically, but imaging might help when clinical findings are inconclusive. This study aimed to systematically evaluate features of orbital syndrome.
Purpose Stereotactic radiosurgery (SRS) has been increasingly used to treat intracranial pathologies in elderly patients. The treatment efficiency of SRS demonstrated meningiomas, with excellent local control. We aimed analyze the safety robotic patients meningiomas. Methods searched for suspected WHO °I meningioma ≥ 60 years old, who underwent CyberKnife (CK) from January 2011 December 2021. Tumor localization was categorized using “CLASS” algorithmic scale. response evaluated Response...
Abstract Background Chronic heart failure (HF) is a common clinical condition associated with adverse outcomes in elderly patients undergoing non-cardiac surgery. This study aimed to estimate clinically applicable NT-proBNP cut-off that predicts postoperative 30-day morbidity surgical cohort. Methods One hundred ninety-nine consecutive older than 65 years elective surgery intermediate or high risk were analysed. Preoperative was measured, and events assessed up day 30. The primary endpoint...
This study aimed to explore the role of CT in septic patients presenting emergency department (ED).
Clustered data arise frequently in many practical applications whenever units are repeatedly observed under a certain condition. One typical example for clustered animal experiments, where several animals share the same cage and should not be assumed to completely independent. Standard methods analysis of such Linear Mixed Models Generalized Estimating Equations—however, checking their assumptions is easy, especially scenarios with small sample sizes, highly skewed, count, ordinal or binary...
Abstract Background Informed consent of the patient prior to surgical procedures is obligatory. A good and informative communication improves patients’ understanding confidence, thus may strengthen patient-doctor relationship. The aim our study was investigate usefulness additional stereoscopic visualization patient-specific imaging during informed conversation. Methods Patients scheduled for a brain tumor surgery were screened this prospectively. primary exclusion criteria cognitive or...
Association rules encode common patterns and structures identified in datasets. They can be derived by association rule mining (ARM) algorithms. The are human-readable allow comprehensible predictions, unlike many other types of prediction Classical ARM algorithms, like Apriori or FP-growth, cannot process interval ratio scaled data (quantitative variables) which limits their applicability. We address this restriction classical making it possible to quantitative variables on the right side a...
Importance Clinicians may be confronted with patients refusing recommended adjuvant therapy (AT) after the primary resection of an advanced oral squamous cell carcinoma (OSCC). However, for this tumor entity, data are lacking regarding oncological outcomes and associated factors refusal AT. Objective To evaluate difference in survival disease recurrence without AT OSCC. Design, Setting, Participants In single-center retrospective matched cohort study, OSCC who refused between January 2010...
Abstract Aims Timely referrals for transplantation and left ventricular assist device (LVAD) play a key role in favourable outcomes patients with advanced heart failure (HF). The purpose of the Catheter Ablation atrial fibrillation patientS end‐sTage faiLure Eligibility Heart Transplantation (CASTLE‐HTx) trial is to test hypothesis that (AF) ablation has beneficial effects on mortality morbidity during ‘waiting time’ (HTx) or prolong time span until LVAD implantation. Methods Results...
BackgroundRecent case reports and small studies have reported activation of the magnet-sensitive switches in cardiovascular implantable electronic devices (CIEDs) by new iPhone 12 series, initiating asynchronous pacing pacemakers suspension antitachycardia therapies cardioverter-defibrillators (ICDs).ObjectiveThe purpose this prospective single-center observational study was to quantify risk magnetic field interactions with CIEDs.MethodsA representative model each CIED series from all...
Abstract Optic neuritis (ON) is a frequent presentation at onset of multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The pathophysiology underlying these diseases, especially MOGAD, still being elucidated. While obesity has been reported to potentially be risk factor for MS, this not explored in NMOSD or MOGAD. We aimed investigate possible association between (body mass index [BMI] > 30...
Background Management of sedation, analgesia, and delirium influences morbidity, mortality, quality life in patients treated intensive care. Assessing indicators as part a management assurance program is an established method to ensure process quality. Currently, there limited research on the effect evaluating economic outcomes. The aim study was investigate adherence indicator analgesia delirium, explore potential effects hospital economics clinical Methods In this retrospective cohort...
Abstract Background Patients who experienced postoperative delirium (POD) are at higher risk of poor outcomes like dementia or death. Previous machine learning models predicting POD mostly relied on time-aggregated features. We aimed to assess the potential temporal patterns in clinical parameters during surgeries predict POD. Methods Long short-term memory (LSTM) and transformer models, directly consuming time series, were compared multi-layer perceptrons (MLPs) trained also fitted hybrid...