A5069720604- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Surgical Oncology
- Facial Trauma and Fracture Management
- Cleft Lip and Palate Research
- Reconstructive Facial Surgery Techniques
- Organ and Tissue Transplantation Research
- Tracheal and airway disorders
- Ophthalmology and Eye Disorders
- Ear and Head Tumors
- Traumatic Ocular and Foreign Body Injuries
- Craniofacial Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Antenna Design and Analysis
- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Facial Nerve Paralysis Treatment and Research
- Lung Cancer Research Studies
- Soft tissue tumors and treatment
- Bone and Joint Diseases
- Macrophage Migration Inhibitory Factor
- Mitochondrial Function and Pathology
Charité - Universitätsmedizin Berlin
2022-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023-2025
Freie Universität Berlin
2023-2025
Humboldt-Universität zu Berlin
2023-2025
University Hospital Bonn
2022
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
2022
RWTH Aachen University
2021
Philipps University of Marburg
2015
Importance Sex differences in head and neck cancer (HNC) incidence suggest a potential contribution of sex hormones. Objective To assess the role exogenous estrogen exposure development HNC female patients. Design, Settings, Participants This large multicenter cohort study using clinical records from TriNetX real-world database included 20 years data (through May 31, 2023) 87 health care organizations. The was searched for medical patients with without according to their chronological age....
Facial Vascularized Composite Allotransplantation (fVCA) restores form and function for patients with severe facial disfigurements, yet multi-center outcome data remain scarce. We accessed the Organ Procurement Transplantation Network (OPTN) database from 2008 to 2024 identify all full- or partial-face fVCA recipients, excluding under 18 years those physiologically impossible BMIs. Of 25 identified patients, 16 (64%) met inclusion criteria (69% male; mean age 43 ± 14 years). Recipients...
Background: Unilateral cleft lip and palates present unique anatomy at the palato-velar-vomerine junction. This region can be widest most challenging part of cleft, where functional fistulas may occur. In 2017, an approach concentrating on nasal was implemented, which rendered repair this transition zone less challenging. study detailed surgical modification, allows easy effective palate thereby reduces fistula rates. Methods: included 71 patients with unilateral who underwent 1-stage...
CD168 has been established as a negative prognostic marker in various tumor entities leading to poor prognosis. Regarding OSCC, there is lack of comprehensive studies that examine the correlation between expression and clinical outcome, hindering implementation this factor into practice. This retrospective analysis included all patients with primary pT1 pT2 pN0 OSCC who received surgical therapy without need for adjuvant (pN0, M0, R0) over seven-year long period. Immunohistochemical staining...
Importance Clinicians may be confronted with patients refusing recommended adjuvant therapy (AT) after the primary resection of an advanced oral squamous cell carcinoma (OSCC). However, for this tumor entity, data are lacking regarding oncological outcomes and associated factors refusal AT. Objective To evaluate difference in survival disease recurrence without AT OSCC. Design, Setting, Participants In single-center retrospective matched cohort study, OSCC who refused between January 2010...
Background: Adipose-derived stem cells (ASCs) are multipotent mesenchymal characterized by their strong regenerative potential and low oxygen consumption. Macrophage migration inhibitory factor (MIF) is a multifunctional chemokine-like cytokine that involved in tissue hypoxia. MIF not only major immunomodulator but also highly expressed adipose such as subcutaneous of chronic non-healing wounds. In the present study, we investigated effect hypoxia on ASCs isolated from healthy versus...
Despite numerous studies addressing the impact of p16
Antiangiogenic medications target the de novo blood vessel formation in tumorigenesis. However, these novel drugs have been linked to onset of medication-related osteonecrosis jaw (MRONJ). The aim this vitro study was examine effects vascular endothelial growth factor A (VEGFA) antibody bevacizumab (BEV) and receptor tyrosine kinase inhibitor (RTKI) sunitinib (SUN) on primary human osteoblasts derived from alveolar bone. Primary (HAOBs) were treated with BEV or SUN for 48 h. Cellular...
To analyze speech outcomes and cleft shape changes in children diagnosed with Robin sequence (RS) treated a customized pre-epiglottic baton plate (PEBP).
The impact of adjuvant or neoadjuvant chemotherapy in the treatment craniofacial bone sarcomas has not been clarified. This study aimed to assess whether survival outcomes differed between patients who underwent chemotherapy.A retrospective search for adult diagnosed with malignant neoplasms bones (International Classification Diseases 10 codes C41.0-C41.1), within past 20 years from access date 28 April 2022, was conducted using TriNetX network (TriNetX, Cambridge, MA, USA). Cohort I...
Abstract Purpose Compromised swallowing, speaking, and local complications are the major disadvantages of established approaches to posterior tongue oropharynx. The mandibular split involves an esthetically unpleasant bipartition lower lip is prone bony non-union or sequestration. conventional pull-through technique on other hand lacks secure reattachment lingually released soft tissues. Methods feasibility a new modified approach was tested three anatomical specimens. CAD/CAM cutting guides...
Background: CUX1 (CUTL1) is a transcription factor able to promote the expression of several genes implicated in cellular proliferation, differentiation and demise. In normal adult cells, it preferentially favors proapoptotic genes. Its aberrant tumor turns its role as foe. It oncogenes survival factors, especially stress condition, thus supporting tumorigenesis. Here, we show activity during hypoxia liver cancer cells.
Abstract Purpose Compromised swallowing and speaking as well local complications are the major disadvantages of established approaches to posterior tongue oropharynx. The mandibular split involves an esthetically unpleasant bipartition lower lip is prone bony non-union or sequestration. traditional pull-through technique on other hand lacks safe reattachment lingually released soft tissues. Methods feasibility a new modified approach was tested three anatomical specimens. CAD/CAM cutting...
Sex-related discrepancies in the prognosis of oral cancer patients have not been clarified. This study aimed to assess survival outcomes and potential prognostic factors female male with cancer.A retrospective search TriNetX network (TriNetX, Cambridge, Massachusetts, USA) was conducted identify diagnosed (International Classification Diseases (ICD)-10 codes C02-C06), within past 20 years from access date April 21, 2023. Patients were categorized according sex (female vs. male). Following...