A5013675736- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Neuroblastoma Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Colorectal and Anal Carcinomas
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Long-Term Effects of COVID-19
- Protein Degradation and Inhibitors
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Heat shock proteins research
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pancreatic function and diabetes
- Pharmacological Receptor Mechanisms and Effects
- Ear and Head Tumors
AngelMed (United States)
2024
Centro de Investigación Biomédica en Red de Salud Mental
2024
Universitat de Barcelona
2024
Max Planck Institute of Psychiatry
2009-2023
Institute of Accelerating Systems and Applications
2023
Instituto de Investigación Biosanitaria de Granada
2016-2018
Hospital Universitario Ramón y Cajal
2006-2013
Max Planck Society
2011
Tel Aviv University
2010
Friedrich-Alexander-Universität Erlangen-Nürnberg
2010
Abstract Rapamycin and its analogues have significant antiproliferative action against a variety of tumors. However, sensitivity to rapamycin is reduced by Akt activation that results from the ablative effects on p70 S6K–induced negative feedback loop blunts phosphoinositide 3-kinase (PI3K)–mediated support for activity. Thus, might be increased imposing an upstream blockade PI3K/Akt pathway. Here, we investigated this model using somatostatin analogue octreotide as tool decrease levels...
Growth hormone (GH) is a major anabolic and the primary regulator of organism growth. Its transcription triggered by GH-releasing (GHRH) through factor cAMP response element-binding protein (CREB) caloric intake. In contrast, deacetylase Sirt1 activated restriction. Therefore, present study investigates how affects CREB function GH synthesis. pharmacological activation with resveratrol (IC50=87 μM) suppressed GHRH-induced secretion from rat anterior pituitary cells in vivo vitro, while...
Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic insight into genetic factors moderating impact of stress can increase our understanding disease processes. Here, we test 3,662 single nucleotide polymorphisms (SNPs) from preselected expression quantitative trait loci in massively parallel reporter assays identify variants that modulate activity regulatory elements sensitive glucocorticoids, important mediators response. Of tested SNP sequences, 547...
Somatic mutations in the GNAS1 gene, encoding α-subunit of heterotrimeric stimulatory G protein (Gαs), occur approximately 40% growth hormone (GH)-secreting pituitary tumours. By altering adenylate cyclase-cAMP-protein kinase A pathway, they unequivocally give somatotroph cells a advantage. Hence, pathogenesis somatotropinomas could be linked to anomalies receptors coupled cAMP second-messenger cascade. Among them, glucose-dependent insulinotropic polypeptide receptor (GIPR) is already known...
Aggressive pituitary tumors are rare but difficult to manage, as there is no effective chemotherapy restrict their growth and cause shrinkage. Within these tumors, growth-promoting cascades, like the PI3K/mTOR pathway, appear be activated. We tested efficacy of two inhibitors this NVP-BKM120 (Buparlisib; pan-PI3K) NVP-BEZ235 (dual PI3K/mTOR), both in vitro on immortalized tumor cells (GH3) primary cell cultures human vivo a rat model prolactin (PRL) (SMtTW3). In vitro, had potent apoptotic...
Background: Adrenocortical carcinoma (ACC) is a rare tumor entity with restricted therapeutic opportunities. HSP90 (Heat Shock Protein 90) chaperone activity fundamental for cell survival and contributes to different oncogenic signaling pathways. Indeed, agents targeting function have shown efficacy in several cancer types. We examined the expression of adrenal tumors evaluated use inhibitors vitro as possible therapy ACC. Methods: Immunohistochemical isoforms was investigated adrenocortical...
To determine the maximum tolerated dose of irinotecan administered every 2 weeks, in combination with a fixed and continuous administration temozolomide, patients glioblastoma at first relapse. Patients received oral temozolomide 50 mg/m divided into three daily doses, except for single 100 dose, before infusion. Irinotecan was given intravenously on days 8 22 28-day cycles. The starting mg/m, this escalated by increments 15 cohorts 3-6 evaluable patients. Determination dose-limiting...
Folliculostellate cells (FS cells) are non-endocrine from the pituitary gland that respond to bacterial endotoxins by producing cytokines. In immune cells, an important component of recognition toll-like receptors (TLRs). Previously, we showed FS express TLR4. The TLR4 ligand lipopolysaccharide (LPS) stimulates interleukin-6 (IL6) production through nuclear factor κB (NFKB) induction. Binding IL6 gp130 receptor activates signal transducer and activator transcription 3 (STAT3), mediator...
Importance The effect of montelukast in reducing symptom duration among outpatients with mild to moderate COVID-19 is uncertain. Objective To assess the effectiveness compared placebo treating COVID-19. Design, Setting, and Participants This randomized clinical trial (Accelerating Therapeutic Interventions Vaccines [ACTIV]–6) was conducted from January 27 through June 23, 2023, during circulation Omicron subvariants. aged 30 years or older confirmed SARS-CoV-2 infection 2 more acute symptoms...
Aflibercept is a recombinant fusion protein that acts by inhibiting tumoural angiogenesis. Efficacy data obtained in the VELOUR randomised study has contributed to approval of aflibercept as second‑line metastatic colorectal cancer (mCRC) treatment following an oxaliplatin‑based regimen. The present reports case series five patients with mCRC, who were treated two centres since 2011 Compassionate Use Program for aflibercept. All had KRAS mutation and previously received palliative...
4179 Background: This phase II trial was designed to determine the pathological response rate of preoperative chemo-radiotherapy. Secondary objectives were: evaluate toxicity profile, disease-free survival (DFS) and overall (OS) conservative surgery. Methods: Patients with histologically confirmed locally advanced adenocarcinoma rectum, (T3 or T4 resectable tumors +/- regional lymph node metastases), no prior treatment for neoplasia, performance status (PS) 0–1, adequate bone marrow, renal...
e14660 Background: Somatostatin analogs (SSTAs) are the treatment of choice for hormonal symptoms associated with NETs. Clinical studies have suggested stabilization or, in rare cases, partial response tumour mass. In a population documented progressive NETs no data antitumoral activity SSTAs given as sole has been presented. We undertook phase II trial (NCT0032646) to evaluate efficacy lanreotide Autogel 120mg on growth stabilisation patients Methods: Thirty from 17 Spanish hospitals...
Abstract Importance The effect of montelukast in reducing symptom duration among outpatients with mild to moderate coronavirus disease 2019 (COVID-19) is uncertain. Objective To assess the effectiveness compared placebo treating COVID-19. Design, Setting, and Participants ACTIV-6 platform randomized clinical trial aims evaluate repurposed medications Between January 27, 2023, June 23, 1250 participants ≥30 years age confirmed SARS-CoV-2 infection ≥2 acute COVID-19 symptoms for ≤7 days, were...
Abstract Exposure to stressful events increases risk for psychiatric disorders. Mechanistic insight into genetic factors moderating the impact of stress can increase our understanding disease processes. Here, we test 3662 SNPs from preselected expression quantitative trait loci in massively parallel reporter assays identify variants that modulate activity regulatory elements sensitive glucocorticoids, important mediators response. Of tested SNP sequences, 547 were located...
<b><i>Background:</i></b> Cushing’s disease (CD) is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary tumours. They express high levels of heat shock protein 90 and factor 1 (HSF1) in comparison to the normal tissue counterpart, indicating activated cellular stress. <b><i>Aims:</i></b> Our objectives were: (1) correlate HSF1 expression with clinical features hormonal/radiological findings CD, (2) investigate effects inhibition as...
<h3>Background</h3> Uveitis is the most common ocular manifestation in Behçet's Disease (BD), which can cause irreversible blindness.<sup><b>1–2</b></sup> <h3>Objectives</h3> To assess efficacy, safety and cost-effectiveness of adalimumab (ADA) therapy optimisation a series patients with uveitis due to BD. <h3>Methods</h3> Multicenter study 74 ADA-treated BD refractory conventional immunosuppressants. Following remission, was performed by increasing ADA dosing interval. Comparison between...
4179 Background: This phase II trial was designed to determine the pathological response rate of preoperative chemo-radiotherapy. Secondary objectives were: evaluate toxicity profile, disease-free survival (DFS) and overall (OS) conservative surgery. Methods: Patients with histologically confirmed locally advanced adenocarcinoma rectum, (T3 or T4 resectable tumors +/- regional lymph node metastases), no prior treatment for neoplasia, performance status (PS) 0–1, adequate bone marrow, renal...
1.1. Introduction: Planned neck dissection after chemoradiotherapy (CRT) in locoregionally advanced head and cancer is controversial. The objective of the present study was to evaluate influence on long-term locoregional control survival patients with stage III-IV squamous cell carcinoma (HNSCC) primary CRT. 1.2. Methods/Patients: We retrospectively analysed control, relapse-free (LRFS), overall (OS) 67 locally-advanced HNSCC treated exclusive CRT at our department between January 1998...