A5002245875- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
- Retinal Development and Disorders
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Tryptophan and brain disorders
- Nutrition and Health in Aging
- Neurological disorders and treatments
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Genetic Neurodegenerative Diseases
- Stress Responses and Cortisol
- Muscle metabolism and nutrition
- Cannabis and Cannabinoid Research
Institut du Fer à Moulin
2019-2025
Sorbonne Université
2019-2025
Inserm
2019-2025
Instituto de Investigación Sanitaria de Santiago
2015-2024
Servicio Gallego de Salud
2010-2024
Centro de Investigación Biomédica en Red
2010-2024
Instituto de Salud Carlos III
2011-2024
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2015-2024
Complejo Hospitalario Universitario de Santiago
2007-2022
Universidade de Santiago de Compostela
2011-2022
Hypothalamic inflammation is a potentially important process in the pathogenesis of high-fat diet-induced metabolic disorders that has recently received significant attention. Microglia are macrophage-like cells central nervous system which activated by pro-inflammatory signals causing local production specific interleukins and cytokines, these turn may further promote systemic disease. Whether or how this microglial activation can be averted reversed unknown. Since running exercise improves...
Abstract Early-life determinants are thought to be a major factor in the rapid increase of obesity. However, while maternal nutrition has been extensively studied, effects breastfeeding by infant on reprogramming energy balance childhood and throughout adulthood remain largely unknown. Here we show that delayed weaning rat pups protects them against diet-induced obesity adulthood, through enhanced brown adipose tissue thermogenesis expenditure. In-depth metabolic phenotyping this model as...
Abnormal glucose metabolism is a central feature of disorders with increased rates cardiovascular disease. Low levels high-density lipoprotein (HDL) are key predictor for We used genetic mouse models HDL (apolipoprotein A-I transgenic [apoA-I tg]) and reduced (apoA-I-deficient ko]) to investigate whether modulates mitochondrial bioenergetics in skeletal muscle.
The role of obestatin, a 23-amino-acid peptide encoded by the ghrelin gene, on control metabolism pre-adipocyte and adipocytes as well adipogenesis was determined. For in vitro assays, adipocyte 3T3-L1 cells were used to assess obestatin effect cell based regulation key enzymatic nodes, Akt AMPK their downstream targets. vivo white adipose tissue (WAT) obtained from male rats under continuous subcutaneous infusion obestatin. Obestatin activated its targets, GSK3α/β, mTOR S6K1, cells....
Over the years, knowledge regarding relevance of cannabinoid system to regulation metabolism has grown steadily. A central interaction between and ghrelin been suggested regulate food intake. Although stomach is main source CB1 receptor expression in described, little information available possible gastric systems integrated control energy homeostasis. The objective present work was assess functional these two terms intake using a combination vivo vitro approaches. demonstrates that...
Growth hormone (GH) is a major anabolic and the primary regulator of organism growth. Its transcription triggered by GH-releasing (GHRH) through factor cAMP response element-binding protein (CREB) caloric intake. In contrast, deacetylase Sirt1 activated restriction. Therefore, present study investigates how affects CREB function GH synthesis. pharmacological activation with resveratrol (IC50=87 μM) suppressed GHRH-induced secretion from rat anterior pituitary cells in vivo vitro, while...
The gut-brain axis is of great importance in the control energy homeostasis. identification uroguanylin (UGN), a peptide released intestines that regulated by nutritional status and anorectic actions, as endogenous ligand for guanylyl cyclase 2C receptor has revealed new system regulation balance. We show chronic central infusion UGN reduces weight gain adiposity diet-induced obese mice. These effects were independent food intake involved specific efferent autonomic pathways. On one hand,...
Glucagon receptor antagonists and humanized glucagon antibodies are currently studied as promising therapies for obesity type II diabetes. Among its variety of actions, reduces food intake, but the molecular mechanisms mediating this effect well resistance totally unknown.Glucagon adenoviral vectors were administered in specific hypothalamic nuclei lean diet-induced obese rats. The expression neuropeptides controlling intake was performed by situ hybridization. regulation factors signaling...
Abstract p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role the hypothalamus remains unknown. Herein, we show mice lacking agouti-related peptide (AgRP), but not proopiomelanocortin (POMC) or steroidogenic factor-1 (SF1) neurons, are more prone to develop diet-induced obesity and reduced brown adipose tissue (BAT) thermogenic activity. AgRP-specific ablation of resulted increased hypothalamic c-Jun N-terminal kinase...
<h3>Objective</h3> Surgical interventions that prevent nutrient exposure to the duodenum are among most successful treatments for obesity and diabetes. However, these highly invasive, irreversible often carry significant risk. The duodenal-endoluminal sleeve (DES) is a flexible tube acts as barrier nutrient-tissue interaction along duodenum. We implanted this device in Zucker Diabetic Fatty (ZDF) rats gain greater understanding of duodenal exclusion on glucose homeostasis. <h3>Design</h3>...
Melanin-concentrating hormone (MCH) is an important regulator of food intake, glucose metabolism, and adiposity. However, the mechanisms mediating these actions remain largely unknown. We used pharmacological genetic approaches to show that sirtuin 1 (SIRT1)/FoxO1 signaling pathway in hypothalamic arcuate nucleus (ARC) mediates MCH-induced feeding, adiposity, intolerance. MCH reduces proopiomelanocortin (POMC) neuronal activity, SIRT1/FoxO1 regulates inhibitory effect on POMC expression....
Huntington's disease (HD) is a devastating due to autosomal dominant mutation in the HTT gene. Its pathophysiology involves multiple molecular alterations including transcriptional defects. We previously showed that HD patients and mouse model, protein levels of non-receptor tyrosine kinase PYK2 were decreased hippocampus viral expression improved hippocampal phenotype. Here, we investigated possible contribution striatum, brain region particularly altered HD. mRNA striatum R6/2 mice, severe...
Ghrelin, a novel gastrointestinal hormone involved in GH regulation, has been postulated as relevant orexigenic peptide released by splanchnic tissues. Descriptive studies have shown that plasma ghrelin levels increase states of negative energy balance or fasting, while decreasing obesity and after feeding. In the present study, organ-culture model gastric tissue explants obtained from rat donors validated for ex vivo experiments. Fasting induced release well mRNA expression were reflected...