A5103149521- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Orthopaedic implants and arthroplasty
- Anesthesia and Pain Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Immunotherapy and Biomarkers
- Scoliosis diagnosis and treatment
- Nerve Injury and Rehabilitation
- Immunotherapy and Immune Responses
- Surgical Simulation and Training
- Heterotopic Ossification and Related Conditions
- Bone Metabolism and Diseases
- Neurosurgical Procedures and Complications
- Neutropenia and Cancer Infections
- Clinical practice guidelines implementation
- Spinal Fractures and Fixation Techniques
- Spinal Hematomas and Complications
- Intracranial Aneurysms: Treatment and Complications
- Urinary and Genital Oncology Studies
- Titanium Alloys Microstructure and Properties
- Pregnancy-related medical research
- Medical Imaging and Analysis
- Acute Ischemic Stroke Management
- Traumatic Ocular and Foreign Body Injuries
University of Lucerne
2024
Hirslanden Klinik St. Anna
2019-2024
Luzerner Kantonsspital
2016-2024
University Hospital of Zurich
2012-2024
Praxis für Hämatologie und Onkologie
2024
Geneva College
2014-2019
University Hospital of Geneva
2014-2018
University of Zurich
2018
Hôpital Beau-Séjour
2014-2018
University of St. Gallen
2009-2017
There are few objective measures of functional impairment to support clinical decision making in lumbar degenerative disc disease (DDD).We present the validation (and reliability measures) Timed Up and Go (TUG) test.In a prospective, 2-center study, 253 consecutive patients were assessed using TUG test. A representative cohort 110 volunteers served as control subjects. The test values for validity reliability.The had excellent intra- (intraclass correlation coefficient: 0.97) interrater...
Abstract All metals in contact with a biological system undergo corrosion through an electrochemical redox reaction. This study investigated whether human osteoclasts (OC) are able to grow on titanium and aluminum, directly corrode the leading release of corresponding metal ions, which believed cause inflammatory reactions activate osteoclastic differentiation. Scanning electron microscopy analysis demonstrated long‐term viable OC cultures surface aluminum foils. Atomic emission spectrometry...
Most metals in contact with biological systems undergo corrosion by an electrochemical process. This study investigated whether human osteoclasts (OC) are able to grow on stainless steel (SS) and directly corrode the metal alloy leading formation of corresponding ions, which may cause inflammatory reactions activate immune system. Scanning electron microscopy analysis demonstrated long-term viable OC cultures evident resorption features surface SS discs were cultured for 21 days. The...
Sex differences in pain perception are known to exist; however, the exact pathomechanism remains unclear. This work aims elucidate sex subjective and objective measures of pain, functional impairment, health-related quality life (HRQoL) patients with lumbar degenerative disc disease. In a prospective 2-center study, back leg (visual analogue scale [VAS]), disability (Oswestry Disability Index Roland-Morris Index), HRQoL (EuroQol-5D Short Form [SF12]) were collected for consecutive undergoing...
OBJECTIVE Patient-reported outcome measures (PROMs) are standard of care for the assessment functional impairment. Subjective increasingly complemented by objective ones, such as “Timed Up and Go” (TUG) test. Currently, only a few studies report pre- postoperative TUG test assessments in patients with lumbar spinal stenosis (LSS). METHODS A prospective two-center database was reviewed to identify LSS who underwent decompression or without fusion. The subjective status estimated using PROMs...
There is increasing evidence that titanium (Ti) ions are released from orthopedic implants, with concentrations in the range of 1 microM tissue and blood, may play a role aseptic loosening implants. This study investigated whether Ti(IV) induce differentiation monocytic osteoclast precursors into osteo-resorptive multinucleated cells influence activation function vitro generated osteoclasts. Human monocytes osteoclasts were exposed to for 10 days. Thereafter, differentiation, activation,...
Abstract There is increasing evidence that titanium ions are released from orthopedic implants by biocorrosion. The aim of this study was to investigate uptake human T‐lymphocytes and its effects on phenotype proliferation. Freshly isolated nonadherent peripheral blood mononuclear cells (NA‐PBMC), were exposed TiCl 4 [Ti(IV)]. Bioavailability distribution Ti(IV) in determined energy‐filtered electron microscopy (EFTEM). challenge nonactivated PHA‐activated assessed flow cytometric analysis...
There is mounting evidence to suggest the involvement of immune system by means activation metal ions released via biocorrosion, in pathophysiologic mechanisms aseptic loosening orthopedic implants. However, detailed how become antigenic and are presented T-lymphocytes, addition local inflammatory response driven, remain be investigated.Human T-lymphocytes were cultured presence a variety before investigating functional phenotypic changes using flow cytometric analysis. Additionally, human...
Digital transformation enables new possibilities to assess objective functional impairment (OFI) in patients with lumbar degenerative disc disease (DDD). This study examines the psychometric properties of an app-based 6-minute walking test (6WT) and determines OFI DDD.
The formation of catheter tip granulomas is an increasingly observed serious complication intrathecally administered medication. This complication, which frequently associated with neurological disturbances, has previously been attributed to high dosages and concentrations intrathecal morphine. Much less commonly, hydromorphone baclofen have also granuloma formation. In the current case, we report a patient who developed her first after 20 months After surgical removal installation new...
First advocated by Santoni et al. in 2009, the cortical bone trajectory pedicle screw technique is an alternative to traditional, convergent that shows comparable biomechanical features and potentially requires less aggressive tissue retraction. Aim of this therapy note describe new focusing on main advantages limitations.The authors provide a detailed description surgically relevant anatomy positioning screws. The surgical then described precise step-by-step manner, stressing complication...
See commentary "A New Possible Standard in Evaluating Lower Extremity Motor Weakness" Volume 17 on page 285.