A5050818857- Tracheal and airway disorders
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Trauma and Emergency Care Studies
- COVID-19 and healthcare impacts
- Inflammatory Bowel Disease
- Pancreatitis Pathology and Treatment
- IL-33, ST2, and ILC Pathways
- Disaster Response and Management
- Esophageal and GI Pathology
- Digestive system and related health
- Neuroendocrine Tumor Research Advances
- Cardiac, Anesthesia and Surgical Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Congenital Diaphragmatic Hernia Studies
- Myasthenia Gravis and Thymoma
- Vitamin D Research Studies
- Fibroblast Growth Factor Research
- Colorectal Cancer Surgical Treatments
- Health, Education, and Physical Culture
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Health and Medical Research Impacts
- Cancer Risks and Factors
NewGen Therapeutics (United States)
2024
Hospital de Manises
2017-2023
Pontificia Universidad Católica de Chile
2020-2022
Altera (United States)
2022
Colciencias
2022
Universidad de La Laguna
2022
Complejo Asistencial Sótero del Río
2022
Universidad de Huelva
2021
Complejo Hospitalario Torrecárdenas
2013
Hospital General de México
1997-2009
The authors assess the long-term results of repeat hepatectomies for recurrent metastases colorectal cancer and determine factors that can predict survival.Safer techniques hepatic resection have allowed surgeons to consider hepatectomy in an increasing number patients. However, higher operative bleeding increased morbidity been reported after hepatectomies, benefit these procedures needs be evaluated.Sixty-four patients from a group 243 resected liver were submitted 83 (64 second, 15 third,...
Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas and its signaling through succinate receptor (SUCNR1) regulates immune function. We analyze SUCNR1 expression intestine Crohn's disease patients role murine intestinal inflammation fibrosis. show that both serum levels surgical resections were higher CD than controls. co-localized with CD86, CD206, α-SMA+ cells human we found a positive significant correlation between α-SMA expression. In isolated...
The pathogenesis of Crohn’s disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate its receptor (SUCNR1) are involved in intestinal inflammation fibrosis, we investigated their relevance EMT disease (CD) fistulas. Succinate levels SUCNR1-expression were analyzed resections from non-Inflammatory Bowel Disease (non-IBD) subjects CD patients with stenosing-B2 or penetrating-B3 complications a murine heterotopic-transplant model...
Abstract The world currently faces the novel severe acute respiratory syndrome coronavirus 2 pandemic. Little is known about effects of a pandemic on non-elective neurosurgical practices, which have continued under modified conditions to reduce spread COVID-19. This knowledge might be critical for ongoing second wave and potential restrictions health care. We aimed determine incidence 30-day mortality rate various procedures during COVID-19 A retrospective, multi-centre observational cohort...
We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of stimulation murine colitis, but both anti- pro-fibrotic effects are associated with different tissues, fibrosis is a frequent complication disease. Thus, we analyzed the pharmacological modulation model intestinal detected that inhibition aggravates, while prevents, fibrosis. These changes inflammation collagen degradation primary fibroblasts. may be useful against
Clinical and experimental research in medicine has been the main path to most of advances diagnosis therapy throughout history, with remarkable surgeons as researchers. To develop good quality surgery is a challenge since special issues difficult process lack time resources discourage residents from conducting research. The aim this narrative review explore barriers for surgeon-researcher. challenges investigate arise many aspects itself. There are methodological difficulties developing...
Intestinal fibrosis is a common complication that affects more than 50% of Crohn´s Disease (CD) patients. There no pharmacological treatment against this complication, with surgery being the only option. Due to unknown role P2X7 in intestinal fibrosis, we aim analyze relevance receptor CD complications. Surgical resections from and non-Inflammatory Bowel (IBD) patients were obtained. was induced two different murine models: heterotopic transplant model chronic-DSS colitis wild-type P2X7-/-...
Vitamin D (VD) deficiency has been associated to Crohn’s disease (CD) pathogenesis, and the exogenous administration of VD improves course disease, but mechanistic basis these observations remains unknown. receptor (VDR) mediates most biological functions this hormone, we aim analyze here expression VDR in intestinal tissue, epithelial cells, fibroblasts from CD patients. The effects on a fibroblast wound healing assay murine fibrosis are also analyzed. Our data show diminished protein...
Intestinal epithelial cells (IECs) constitute a defensive physical barrier in mucosal tissues and their disruption is involved the etiopathogenesis of several inflammatory pathologies, such as Ulcerative Colitis (UC). Recently, succinate receptor SUCNR1 was associated with activation pathways cell types, but little known about its role IECs. We aimed to analyze inflammasome priming relevance UC. Inflammatory markers were analyzed HT29 treated and/or an cocktail transfected siRNA murine DSS...
Background: Fibrosis is a common complication of Crohn’s disease (CD) in which macrophages play central role. Epithelial-mesenchymal transition (EMT) and the WNT pathway have been associated with fibrosis. We aim to analyse relevance tissue microenvironment macrophage phenotype EMT process. Methods: Intestinal surgical resections are obtained from control CD patients stenotic or penetrating behaviour. Cytokine’s expression, phenotype, markers signalling determined by WB, RT-PCR, ELISA...
Reflecting the first wave COVID-19 pandemic in Central Europe (i.e. March 16th-April 15th, 2020) neurosurgical community witnessed a general diminution incidence of emergency cases, which was impelled by reduced number traumatic brain injuries (TBI), spine conditions, and chronic subdural hematomas (CSDH). This appeared to be associated with restrictions imposed on mobility within countries but also possible delayed patient introduction interdisciplinary medical counseling. In response one...
Abstract Pancreatic pseudocyst is a common complication of acute and chronic pancreatitis. However, spleen involvement in pancreatitis rare. We present patient with pancreatic tail splenic extension rupture. Due to initial stability, conservative management was decided. he developed tachycardia severe abdominal pain associated signs peritoneal irritation, requiring an emergency laparotomy. A large identified addition ruptured spleen. Splenectomy double layer hand-sewn gastrocystic...
Abstract Introduction: Adoptive cell therapies using CAR T cells achieve great success in treating hematological malignances. Despite high complete response rates (70%-90%) relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia with current CD19 therapies, 40%-60% of responders experience relapse up to 60% due antigen loss. Similarly, despite initial treated r/r multiple myeloma patients, most eventually disease progression relapses Dual targeting approaches combining two tumor...
Abstract Objective . To determine whether tenidap regulates extracellular matrix metabolism in chronic arthritis. Methods Antigen arthritis was induced the knees of 30 rabbits. Animals were distributed into 3 groups: untreated, tenidap‐treated, and diclofenactreated Three weeks after disease induction, synovial membranes extracted processed for histopathologic examination detection type I collagen (CI) fibronectin (FN) by immunoperoxidase. Simultaneously, we analyzed vitro effect on healthy...
The purpose of this study was to demonstrate the existing correlation between bronchoscopic examination and helieal computed tomography with three-dimensional reconstructions. Eighteen patients non-small cell carcinoma lung were studied. A good observed in stenosis stem lobar bronchi, either intrinsic or extrinsic. images reveal spatial location tumoral mass, alterations intrathoracic structures, parenchyma secondary growth. internal external views bronchial tree also correlate well findings...
Unidad de Neumología Hospital General México and Facultad Medicina. U.N.A.M. City, Mexico
Abstract Background Ulcerative colitis (UC) is characterized by a diffuse, continuous, and chronic inflammation of mucosa submucosa layers in the colon whose etiology still unknown. Intestinal microbiota dysbiosis alterations metabolomic profile have been reported mucosal biopsies from Inflammatory Bowel Disease (IBD) patients. We aim to characterize composition colonic resections UC Methods Colonic (n=18) non-IBD (n=20) patients were obtained. Microbiota identification, classification was...