A5048093549- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Surgical site infection prevention
- Infection Control in Healthcare
- Neonatal and Maternal Infections
- Urinary Tract Infections Management
- Health and Medical Studies
- Bacterial Identification and Susceptibility Testing
- Central Venous Catheters and Hemodialysis
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Medical Practices and Rehabilitation
- Emergency and Acute Care Studies
- Clostridium difficile and Clostridium perfringens research
- Intensive Care Unit Cognitive Disorders
- Healthcare cost, quality, practices
- Respiratory Support and Mechanisms
- Neonatal Health and Biochemistry
- Medical and Health Sciences Research
- Pediatric health and respiratory diseases
- Streptococcal Infections and Treatments
- Infant Development and Preterm Care
Institut für Hygiene und Umwelt
2015-2025
Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
2000-2025
Humboldt-Universität zu Berlin
2003-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2025
Institute for Health Metrics and Evaluation
2024
University of Washington
2024
Deutsches Herzzentrum der Charité
2023
Engineering Associates (United States)
2016
München Klinik
2014
More than 800 hospitals and 586 intensive care units (ICUs) in Germany currently participate a nationwide surveillance system for nosocomial infections (Krankenhaus-Infektions-Surveillance-System, KISS), which collects data on the frequency of pathogens appearance special epidemiological importance.Data were collected from ICUs regarding lower respiratory tract infections, primary sepsis, urinary temporal relation these types infection to use specific medical devices (invasive ventilation,...
Abstract Introduction Pneumonia is a very common nosocomial infection in intensive care units (ICUs). Many studies have investigated risk factors for the development of and its consequences. However, evaluation most theses disregards fact that there are additional competing events, such as discharge or death. Methods A prospective cohort study was conducted over 18 months five at one university hospital. All patients were admitted least 2 days included, surveillance pneumonia conducted....
Among European countries, Germany has one of the highest proportions vancomycin-resistant Enterococcus faecium bloodstream infections. The aim this study was to investigate development enterococci (VRE) in German hospitals and consider regional distribution VRE Germany. Data from three components national nosocomial surveillance system (KISS) period 2007–12 were used for analysis: ICU-KISS data on primary infections urinary tract intensive care units (ICUs); OP-KISS surgical site...
Carbapenemase-producing Enterobacteriaceae (CPE) have become a major problem for healthcare systems worldwide. While the first reports from European hospitals described introduction of CPE endemic countries, there is now growing number describing outbreaks in hospitals. Here we report an outbreak Carbapenem-resistant K. pneumoniae German University hospital which was part associated to duodenoscopy.Between December 6, 2012 and January 10, 2013, carbapenem-resistant (CRKP) cultured 12...
Enterococci are frequent pathogens causing nosocomial infections in Germany. Infections due to strains with vancomycin resistance high when compared other European states. Therefore, the study aimed describe recent progression of vancomycin-resistant enterococci (VRE) Germany.We analyzed data from two components German national infection surveillance system for period 2007-2016. For primary bloodstream (BSIs) and urinary tract (UTIs) we used intensive care units surgical site (SSIs)...
Infants with very low birthweight (< 1 500 g, VLBW) are at increased risk for nosocomial infections (NI). In 2 000, we implemented a surveillance system VLBW infants in Germany: NEO-KISS. 2005, joint committee of healthcare providers and insurance companies required German neonatology departments to participate. As result, NEO-KISS is now nationwide NI infants.We present data collected between 2007 2011 by 228 departments. Rates sepsis, pneumonia necrotising enterocolitis (NEC) were...
Abstract Purpose Corticosteroids, in particular dexamethasone, are one of the primary treatment options for critically ill COVID-19 patients. However, there a growing number cases that involve COVID-19-associated pulmonary aspergillosis (CAPA), and it is unclear whether dexamethasone represents risk factor CAPA. Our aim was to investigate possible association recommended therapy with Methods We performed study based on cohort patients treated 2020 our 13 intensive care units at Charité...
A national point prevalence survey (PPS) of healthcare-associated infections (HAI) and antibiotic use (AU) was carried out in Germany 2022 the framework European PPS conducted by Centre for Disease Prevention Control (ECDC). The objective to determine HAI AU German hospitals compare obtained values with those most recent previous PPS, which 2016.
Objective: The proportion of intensive care unit (ICU)-acquired infections that are a consequence nosocomial cross-transmission between patients in tertiary ICUs is unknown. Such information would be useful for the implementation appropriate infection control measures. Design: A prospective cohort study during 18 months. Setting: Five from two university hospitals. Patients: All admitted ≥48 hrs. Measurement: ICU-acquired were ascertained daily bedside patient and chart reviews. Episodes...
Reliable data on the costs attributable to nosocomial infection (NI) are crucial demonstrating real cost-effectiveness of control measures. Several studies investigating this issue with regard intensive care unit (ICU) patients have probably overestimated, as a result inappropriate study methods, part played by NIs in prolonging length stay.Data from prospective incidence NI 5 ICUs over period 18 months formed basis analysis. For describing temporal dynamics data, multistate model was used....
This study aimed to determine the prevalence of and risk factors for colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) methicillin-resistant Staphylococcus aureus (MRSA) in very low birth weight (VLBW; <1500 g) infants their mothers. investigation was conducted perinatal centre at Charité Berlin between May 2012 June 2013. VLBW mothers were screened ESBL-E MRSA. Demographic clinical data obtained from German nationwide surveillance system nosocomial...
Laminar airflow (LAF) systems are widely used, at least in orthopedic surgery. However, there is still controversial discussion about the influence of LAF on surgical site infection (SSI) rates. The size ceiling also often a question debate. Our objective to determine effect this technique under conditions actual rather than ideal use.Cohort study using multivariate analysis with generalized estimating equations method.Data for hip and knee prosthesis procedures from hospitals participating...
Background Older age is frequently cited as a risk factor for healthcare-associated infections in general, and surgical site (SSIs) specifically. Aim We aimed to investigate the correlation between SSI occurrence. Methods Data on total hip replacement (THR) knee (TKR) surgeries resulting SSIs documented German national surveillance network from 10-year period 2009 2018 were selected analysis. rates adjusted odds ratios (AOR) calculated multivariable analysis determine factors occurrence was...
The choice of empirical treatment nosocomial pneumonia in the intensive-care unit (ICU) used to rely on interval after start mechanical ventilation. Nowadays, however, question whether fact there is a difference distribution causative pathogens under debate. Data from 308 ICUs German National Nosocomial Infection Surveillance System, including information relevant isolated 11,285 cases 1997 2004, were for our evaluation. Each individual case was allocated either early- or late-onset...