A5069468301- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Lipid Membrane Structure and Behavior
- Diabetes Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Sphingolipid Metabolism and Signaling
German Centre for Cardiovascular Research
2022-2025
Freie Universität Berlin
2022-2025
Humboldt-Universität zu Berlin
2024-2025
Charité - Universitätsmedizin Berlin
2022-2025
MedStar Washington Hospital Center
2025
Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney (CKD). However, pathogenesis CVD CKD remains incompletely understood. Endothelial extracellular vesicles (EC-EVs) have previously been associated with CVD. We hypothesized that alters EV release and cargo, subsequently promoting vascular remodelling. recruited 94 children CKD, including patients after transplantation healthy donors, performed phenotyping functional analyses absence age-related comorbidities....
BACKGROUND: The microbially produced amino acid–derived metabolite imidazole propionate (ImP) contributes to the pathogenesis of type 2 diabetes. However, effects ImP on endothelial cell (EC) physiology and its role in atherosclerotic coronary artery disease are unknown. Using both human animal model studies, we investigated potential contributory development atherosclerosis. METHODS: Plasma levels were measured patients undergoing elective cardiac angiography (n=831) by ultra-high...
Background: Epidemiological studies have identified pneumonia to be closely linked an increased risk for cardiovascular events. Potential causality of this association, however, remains established, and underlying mechanisms are yet resolved. Here, we tested the hypothesis that prior pulmonary infection with Streptococcus pneumoniae accelerates development atherosclerotic phenotype in mice. Such a would explain epidemiological data. Methods: Atheroprone ApoE −/− mice were fed high fat diet,...