A5026202862- Cell death mechanisms and regulation
- Bone Metabolism and Diseases
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Atherosclerosis and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- Diet and metabolism studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Biomedical Ethics and Regulation
- MicroRNA in disease regulation
- Photoacoustic and Ultrasonic Imaging
- Protease and Inhibitor Mechanisms
- Pluripotent Stem Cells Research
- Blood Coagulation and Thrombosis Mechanisms
- Coronary Interventions and Diagnostics
Charité - Universitätsmedizin Berlin
2018-2024
Deutsches Herzzentrum der Charité
2024
German Centre for Cardiovascular Research
2018-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020
University of Zurich
2020
Humboldt-Universität zu Berlin
2018
Freie Universität Berlin
2018
Abstract Aims Acute coronary syndromes with intact fibrous cap (IFC-ACS), i.e. caused by plaque erosion, account for approximately one-third of ACS. However, the underlying pathophysiological mechanisms as compared ACS rupture (RFC-ACS) remain largely undefined. The prospective translational OPTICO-ACS study programme investigates first time microenvironment ACS-causing culprit lesions (CL) molecular high-resolution intracoronary imaging and simultaneous local immunological phenotyping....
BACKGROUND: The microbially produced amino acid–derived metabolite imidazole propionate (ImP) contributes to the pathogenesis of type 2 diabetes. However, effects ImP on endothelial cell (EC) physiology and its role in atherosclerotic coronary artery disease are unknown. Using both human animal model studies, we investigated potential contributory development atherosclerosis. METHODS: Plasma levels were measured patients undergoing elective cardiac angiography (n=831) by ultra-high...
Human induced pluripotent stem cells (hiPSCs) hold great potential for modeling human diseases and the development of innovative therapeutic approaches. Here, we report on a novel, simplified differentiation method forming functional osteoclasts from hiPSCs. The three-step protocol starts with embryoid body formation, followed by hematopoietic specification, finally osteoclast differentiation. We observed continuous production monocyte-like over period up to 9 weeks, generating sufficient...
Background: Protease-activated receptor 1 (PAR1) and toll-like receptors (TLRs) are inflammatory mediators contributing to atherogenesis atherothrombosis. Vorapaxar, which selectively antagonizes PAR1-signaling, is an approved, add-on antiplatelet therapy for secondary prevention. The non-hemostatic, platelet-independent, pleiotropic effects of vorapaxar have not yet been studied. Methods Results: Cellular targets PAR1 signaling in the vasculature were identified three patient cohorts with...
Extracellular vesicles are released upon cellular activation and mediate inter-cellular communication. Individual species of extracellular might have divergent roles in vascular homeostasis may show different responses to therapies such as exercise training.We examine endothelial effects medium-size small from the same individual with or without chronic coronary syndrome, syndrome patients participating a four-week high-intensity interval training intervention.Human aortic cells were exposed...
Abstract Background The microbially generated amino acid-derived metabolite imidazole propionate (ImP) contributes to the pathogenesis of type 2 diabetes. However, effect ImP on endothelial cell physiology and its role in atherosclerotic coronary artery disease (CAD) is unknown. Using both human animal model studies, we investigated potential contributory development atherosclerosis. Methods Plasma levels were measured patients undergoing elective cardiac angiography (n = 831) by means ultra...