A5080955101- Coronary Interventions and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
Franklin University
2024
Charité - Universitätsmedizin Berlin
2020-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
German Centre for Cardiovascular Research
2020-2023
Deutsches Herzzentrum der Charité
2023
Abstract Aims Acute coronary syndromes with intact fibrous cap (IFC-ACS), i.e. caused by plaque erosion, account for approximately one-third of ACS. However, the underlying pathophysiological mechanisms as compared ACS rupture (RFC-ACS) remain largely undefined. The prospective translational OPTICO-ACS study programme investigates first time microenvironment ACS-causing culprit lesions (CL) molecular high-resolution intracoronary imaging and simultaneous local immunological phenotyping....
Abstract Aims Rupture of the fibrous cap (RFC) and erosion an intact (IFC) are two predominant mechanisms causing acute coronary syndromes (ACS). It is uncertain whether clinical outcomes different following RFC-ACS vs. IFC-ACS this affected by a specific inflammatory response. The prospective, translational OPTIcal-COherence Tomography in Acute Coronary Syndrome study programme investigates impact culprit lesion phenotype on profiles prognosis ACS patients. Methods results This analysis...
Abstract Aims Coronary microevaginations (CMEs) represent an outward bulge of coronary plaques and have been introduced as a sign adverse vascular remodelling following device implantation. However, their role in atherosclerosis plaque destabilization the absence intervention is unknown. This study aimed to investigate CME novel feature vulnerability characterize its associated inflammatory cell–vessel–wall interactions. Methods results A total 557 patients from translational OPTICO-ACS...
Abstract Background Optical coherence tomography (OCT) has refined acute coronary syndrome (ACS)-management by enabling in-depth characterization of culprit lesions. Differentiating between plaques with ruptured (RFC) and intact fibrous cap (IFC) shaped clinical decision making. However, the systemic vascular changes associated different plaque morphologies remain unexplored. Purpose To investigate arterial stiffness among ACS-causing (RFC vs. IFC) its prognostic value post-ACS. Methods We...
Abstract Aims Cholesterol chrystals (CC) represent a feature of advanced plaque remodeling. Optical coherence tomography (OCT) allows for detailed morphological assessment the culprit lesion, including presence CCs, in vivo. Since CCs have been identified as prognostically relevant coronary artery disease (CAD), present analysis aims to further characterize their impact on adverse cardiovascular outcome large cohort patients, presenting with acute syndrome (ACS). Methods Within translational...