A5029180984- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Long-Term Effects of COVID-19
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Patient Satisfaction in Healthcare
- Nitric Oxide and Endothelin Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Radiomics and Machine Learning in Medical Imaging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Agricultural Science and Fertilization
- Cytokine Signaling Pathways and Interactions
- Plant Micronutrient Interactions and Effects
- Protease and Inhibitor Mechanisms
- Optical Coherence Tomography Applications
- Nitrogen and Sulfur Effects on Brassica
Royal College of Surgeons in Ireland
2021-2023
Deutsches Herzzentrum München
2016-2023
Technical University of Munich
2016-2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Cardiovascular Institute Hospital
2021-2023
Mater Misericordiae University Hospital
2020-2022
University Hospitals Plymouth NHS Trust
2019-2022
Deutsches Herzzentrum der Charité
2018-2021
University of Medicine and Health Sciences
2021
Abstract Aims Acute coronary syndromes with intact fibrous cap (IFC-ACS), i.e. caused by plaque erosion, account for approximately one-third of ACS. However, the underlying pathophysiological mechanisms as compared ACS rupture (RFC-ACS) remain largely undefined. The prospective translational OPTICO-ACS study programme investigates first time microenvironment ACS-causing culprit lesions (CL) molecular high-resolution intracoronary imaging and simultaneous local immunological phenotyping....
Abstract Aims Rupture of the fibrous cap (RFC) and erosion an intact (IFC) are two predominant mechanisms causing acute coronary syndromes (ACS). It is uncertain whether clinical outcomes different following RFC-ACS vs. IFC-ACS this affected by a specific inflammatory response. The prospective, translational OPTIcal-COherence Tomography in Acute Coronary Syndrome study programme investigates impact culprit lesion phenotype on profiles prognosis ACS patients. Methods results This analysis...
The comparative efficacy of balloon-based techniques to prepare severely calcified coronary lesions before stenting remains poorly studied.We sought compare stent expansion following preparation with either a super high-pressure balloon or scoring balloon.In this randomised, open-label trial, patients were enrolled at five centres in Germany and Switzerland. After unsuccessful lesion standard non-compliant (<30% reduction baseline diameter stenosis), participants randomised predilation...
In one-third of patients with acute coronary syndrome (ACS), thrombosis occurs despite an intact fibrous cap (IFC) (IFC-ACS, 'plaque erosion'). Recent studies emphasize neutrophils as the immediate inflammatory response in this pathology, but their exact molecular activation patterns are still poorly understood and may represent future therapeutic targets.Thirty-two IFC-ACS matched ACS ruptured (RFC) (RFC-ACS) from OPTICO-ACS study were included, blood samples collected local site culprit...
Abstract The correlation between sub‐epidermal moisture (SEM) and other early indicators of pressure ulcer (PU) development is yet to be determined. This three‐part series aims bridge this knowledge gap, through investigating SEM its with evidence‐based technologies assessments. article focuses on the ultrasound. A prospective cohort observational study was undertaken February November 2021. Patients undergoing three surgery types were consecutively enrolled following informed consent....
Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only single trial investigated patients undergoing percutaneous intervention (PCI) for acute myocardial infarction (MI). We aimed to compare outcomes BRS vs. DES in PCI MI. did prospective, randomized, multicentre, non-inferiority, clinical everolimus-eluting durable polymer (EES)...
Drug-coated balloons (DCB) and drug-eluting stents (DES) represent the currently recommended treatments for in-stent restenosis (ISR). Optical coherence tomography (OCT) allows detailed neointimal characterisation which can guide treatment strategies.The aims of this study were first, to assess relation between pattern clinical outcomes following (ISR) treatment, second, explore a potential interaction modality relative outcomes.Patients undergoing OCT-guided (DCB or DES) ISR in three...
Drug-coated balloon (DCB) angioplasty with paclitaxel-eluting devices is an established treatment for coronary in-stent restenosis (ISR). Biolimus A9™ (BA9), a sirolimus analogue enhanced lipophilicity, may facilitate local drug delivery into vascular tissue. A novel DCB coated represents alternative to traditional paclitaxel- and sirolimus-coated devices. Hence, we sought investigate the safety efficacy of this in ISR.REFORM (NCT04079192) prospective, multicenter, single blind, randomized...
The biology of oral squamous cell carcinoma (OSCC), including its progression from dysplasia to carcinoma, "field effects", genetic changes in tumor associated mucosa (TAM) and effect matrix metalloproteinases breaking down proteins facilitate invasion, has been well documented. However, what remains be done is extrapolate this knowledge improve patient care.The aim study was observe the extracellular (ECM) with routine histochemical stains available most histopathologists.The includes 72...
A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with efficacy aspirin inhibit reactivity. This study sought investigate whether homozygous (rs7692387) allele carriers display higher on-aspirin reactivity and early after intervention.The association genotype was analysed in genetics substudy ISAR-ASPI registry (n = 1678) using impedance aggregometry. clinical...
Background: The pathomechanisms underlying restenosis of the bioabsorbable sirolimus-eluting metallic scaffold (Magmaris) remain unknown. Using serial optical coherence tomography, we investigated causes restenosis, including contribution late recoil versus neointimal hyperplasia. Methods: Patients enrolled in BIOSOLVE-II undergoing angiography and tomography (post-intervention follow-up: 6 months and/or 1 year) were analyzed. divided into 2 groups according to angiographic in-scaffold lumen...
Genetic variants are considered as one of the main determinants concentration serum lipids and coronary artery disease (CAD). Polymorphisms in Apolipoprotein (Apo) AI-CIII-AIV gene cluster has been known to affect concentrations various lipid sub-fractions risk CAD. The present study assessed associations between polymorphisms Apo cluster, [ApoA-I,-75G > A, (rs1799837); ApoC-III 3238C G, (
Background Stent underexpansion has been known to be associated with worse outcomes. We sought define optical coherence tomography assessed optimal stent expansion index (SEI), which associates lower incidence of follow-up major adverse cardiac events (MACEs). Methods and Results A total 315 patients (involving 370 lesions) who underwent tomography-aided coronary stenting were retrospectively included. SEI was calculated separately for equal halves each stented segment using minimum...
There is growing interest in the roles of temperature, epidermal hydration (EH) and pain pressure ulcer (PU) development. Investigating correlations between these measures sub-epidermal moisture (SEM) will address this knowledge deficit. A prospective observational study enrolled 60 surgical patients from February to November 2021. SEM, EH were assessed using a SEM scanner, thermography imaging, skin device numeric intensity scale, respectively. Measurements taken at sacrum, both heels...
Monocytes play a critical role in atherosclerosis. CX3CR1 is expressed on monocytes and acts as either monocyte chemokine receptor or an adhesion molecule. Two common variants of CX3CR1, V249I T280M, reportedly decrease the coronary artery risk.We have examined genotype 152 early-onset disease (CAD) patients (age ≤ 45 years) 156 late-onset CAD ≥ 55 300 healthy controls. Homozygous alleles CX3CR1-V249 T280 were found associated with early onset (odds ratio [OR] 2.7, p<0.0001 OR 2.76,...
The aims of the study were to ascertain difference in lipid levels ‘Young’ onset coronary artery disease (CAD) (≤ 45 years) vs. ‘Not so Young’ CAD (≥ 55 among north Indians and also investigate determinants ‘dyslipidaemia’ patients. This was a prospective, multicentric, randomised, observational carried eight centres UP, India. All blood investigations performed employing central laboratory. Out total 435 patients studied, 218 ‘young group’ (YG) 235 Young Group’ (NSYG). Dyslipidaemia more...