A5103029242- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Renal and related cancers
- Reproductive Physiology in Livestock
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Diet and metabolism studies
- Gut microbiota and health
- Genetic and phenotypic traits in livestock
- Pelvic floor disorders treatments
- Wnt/β-catenin signaling in development and cancer
- Infant Nutrition and Health
- Metabolomics and Mass Spectrometry Studies
- Hippo pathway signaling and YAP/TAZ
- Phytoestrogen effects and research
- Reproductive tract infections research
- Urinary Bladder and Prostate Research
- Reproductive Health and Technologies
- Seaweed-derived Bioactive Compounds
- Animal health and immunology
- Cell Adhesion Molecules Research
- Ruminant Nutrition and Digestive Physiology
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022-2025
Max Delbrück Center
2024-2025
University of Colorado Boulder
2023
Nanyang Technological University
2023
Ross University School of Veterinary Medicine
2018-2020
University of Ottawa
2017
Hanyang University
2004-2015
CHA Gangnam Medical Center
2009-2012
CHA University
2003-2010
CHA Bundang Medical Center
2009
Abstract Angiogenesis, the process by which endothelial cells (ECs) form new blood vessels from existing ones, is intimately linked to tissue’s metabolic milieu and often occurs at nutrient-deficient sites. However, ECs rely on sufficient resources support growth proliferation. How nutrient acquisition usage are regulated unknown. Here we show that these processes instructed Yes-associated protein 1 (YAP)/WW domain-containing transcription regulator (WWTR1/TAZ)-transcriptional enhanced...
Abstract Objectives: The aim of the present study was to improve efficiency isolation and optimize proliferative potential human spermatogonial stem cells (SSCs) obtained from obstructive azoospermic (OA) non‐obstructive (NOA) patients, further, characterize these for use in infertility treatment or reproductive biology. Materials methods: We have applied a cell‐sorting method, using collagen magnetic activated cell separation overcome obstacles, developing collection system, simple...
BACKGROUND: The microbially produced amino acid–derived metabolite imidazole propionate (ImP) contributes to the pathogenesis of type 2 diabetes. However, effects ImP on endothelial cell (EC) physiology and its role in atherosclerotic coronary artery disease are unknown. Using both human animal model studies, we investigated potential contributory development atherosclerosis. METHODS: Plasma levels were measured patients undergoing elective cardiac angiography (n=831) by ultra-high...
Abstract Infant fecal metabolomics can provide valuable insights into the associations of nutrition, dietary patterns, and health outcomes in early life. Breastmilk is typically classified as best source nutrition for nearly all infants. However, exclusive breastfeeding may not always be possible This study aimed to characterize between levels mixed formula feeding, along with solid food consumption infant metabolome at 1- 6-months age. As a secondary aim, we examined how feeding-associated...
Early diagnosis of endometritis in dairy cattle is currently requires invasive techniques and specialist expertise. The goal this study to utilize a gel-free mass-spectrometry based proteomics approach compare the plasma proteome with cytological those without. Blood samples were collected from cows (N = 112) seven days postpartum (DPP). Plasma cohort 20 animals (n 10) without as classified 21 DPP selected for proteomic analysis. Differential abundances proteins between two animal groups...
Abstract The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days (DPP) from 112 Holstein–Friesian dairy cows, 27 retrospectively chosen for RNA-seq on basis disease classification [ten healthy and an additional 17 diagnosed with cytological endometritis (CYTO), or purulent vaginal discharge (PVD)] 21 DPP. 297 genes...
Epithelial-to-mesenchymal transition (EMT) plays a crucial role in metastatic cancer progression, and current research, which relies heavily on 2D monolayer cultures, falls short recapitulating the complexity of 3D tumor microenvironment. To address this limitation, transcriptomic meta-analysis is conducted diverse types undergoing EMT cultures. It found that mechanotransduction elevated cultures further intensified during EMT, but not EMT. This analysis reveals distinct gene signature,...
To assess the effects of isoflavones and 17β-estradiol on vaginal epithelium extracellular matrix hyaluronic acid (HA) in diabetic rat model.Sixty adult, virgin, female rats underwent ovariectomy, then randomization into six groups ten animals each: GI, sham ovariectomized control animals; GII, GIII, receiving propylene glycol vehicle; GIV, GV, treated with soy (150 mg/kg by gavage); GVI, estrogen (17β-estradiol, 10 mg/kg, subcutaneously). Treatment took place over 30 consecutive days. After...
Abstract Background The microbially generated amino acid-derived metabolite imidazole propionate (ImP) contributes to the pathogenesis of type 2 diabetes. However, effect ImP on endothelial cell physiology and its role in atherosclerotic coronary artery disease (CAD) is unknown. Using both human animal model studies, we investigated potential contributory development atherosclerosis. Methods Plasma levels were measured patients undergoing elective cardiac angiography (n = 831) by means ultra...