A5101748953- Hippo pathway signaling and YAP/TAZ
- Delphi Technique in Research
- interferon and immune responses
- Kruppel-like factors research
- Cellular Mechanics and Interactions
- Cancer-related gene regulation
- RNA Research and Splicing
- Microtubule and mitosis dynamics
Italian Association for Cancer Research
2024
University of Padua
2019-2024
IFOM
2022
National Institutes of Health
2017
National Human Genome Research Institute
2017
Abstract Angiogenesis, the process by which endothelial cells (ECs) form new blood vessels from existing ones, is intimately linked to tissue’s metabolic milieu and often occurs at nutrient-deficient sites. However, ECs rely on sufficient resources support growth proliferation. How nutrient acquisition usage are regulated unknown. Here we show that these processes instructed Yes-associated protein 1 (YAP)/WW domain-containing transcription regulator (WWTR1/TAZ)-transcriptional enhanced...
Confined cell migration hampers genome integrity and activates the ATR ATM mechano-transduction pathways. We investigated whether mechanical stress generated by metastatic interstitial contributes to enhanced chromosomal instability observed in tumor cells. employed live imaging, micro-fluidic approaches, scRNA-seq follow fate of cells experiencing confined migration. found that, despite functional ATR, ATM, spindle assembly checkpoint (SAC) pathways, dividing across constriction frequently...
Enhanced YAP/TAZ activity is emerging as common trait of multiple solid tumors in humans. Strikingly, mouse models, adult organs lacking are unable to develop without overt side effects for normal tissue homeostasis, making prime candidates cancer therapy. That said, have physiological functions during repair, being essential organ regeneration after injury. typically inactive tissues but potently induced by mechanical and physical cues that the cell receives from its microenvironment, such...
Abstract Enhanced YAP/TAZ activity is emerging as common trait of multiple solid tumors in humans. Strikingly, mouse models, adult organs lacking are unable to develop without overt side effects for normal tissue homeostasis, making prime candidates cancer therapy. That said, have physiological functions during repair, being essential organ regeneration after injury. typically inactive tissues but potently induced by mechanical and physical cues that the cell receives from its...